Nutrabiotech Bay85-3934 98% 3G Powder, high purity Molidustat powder, pan HIF-PH/PHD inhibitor, HIF-1α/HIF-2α stabilizer, hypoxia signaling and EPO regulation research raw material

Molidustat CAS 1154028-82-6 98% Purity HIF-PH Inhibitor Powder BAY 85-3934

High purity Molidustat powder CAS 1154028-82-6 with 98% HPLC purity. Also known as BAY 85-3934, oral HIF-PH inhibitor for chronic kidney disease anemia research, factory bulk supply, full certificates and fast global delivery.
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Molidustat BAY 85-3934 (CAS 1154028-82-6) HIF-PH Inhibitor | Anemia / CKD Research

Molidustat CAS 1154028-82-6
Oral HIF Prolyl Hydroxylase Inhibitor (Anemia / CKD)

Molidustat (CAS 1154028-82-6), also BAY 85-3934, is an oral HIF prolyl hydroxylase (HIF-PH) inhibitor that stabilizes HIF-α, increasing endogenous erythropoietin (EPO) and improving iron utilization to treat anemia of CKD. A hypoxia-mimetic mechanism similar to daprodustat, with its own selectivity and PK. Formula C13H14N8O2, MW 314.30. Research-grade with COA.

HIF-PH InhibitorAnemiaCKDMolidustatBAY 85-3934HypoxiaEPOErythropoiesis
Request a Quote Technical Specs
314.30
MW (C13H14N8O2)
≥98%
Purity (HPLC)
HIF-PH
Hypoxia mimetic

Molecular Information

Name: Molidustat (BAY 85-3934)
CAS: 1154028-82-6
Formula: C13H14N8O2
MW: 314.30 g/mol
Class: HIF prolyl hydroxylase inhibitor
Core: Pyrimidinyl pyrazolone triazole
Target: HIF-PH (PHD)
Activity: HIF-α stabilization; EPO induction
MP: Not firmly reported
Appearance: White to off-white powder
Synonyms: BAY 85-3934
Storage: -20°C, protect from light
1154028-82-6
🧪
CAS Number
314.30
⚖️
Molecular Weight
HIF-PH Inhibitor
🎯
Primary Activity
≥98%
✅
Purity

Product Technical Specifications

Complete physicochemical properties and QC parameters for Molidustat (CAS 1154028-82-6)

📋 Physicochemical Properties

  • Product NameMolidustat (BAY 85-3934)
  • IUPAC Name2-(6-morpholin-4-ylpyrimidin-4-yl)-4-(triazol-1-yl)-1H-pyrazol-3-one
  • CAS Number1154028-82-6
  • SynonymsMolidustat; BAY 85-3934
  • Molecular FormulaC13H14N8O2
  • Molecular Weight314.30 g/mol
  • SourceSynthetic HIF-PH inhibitor
  • AppearanceWhite to off-white powder
  • Water SolubilityLow
  • Organic SolubilityDMSO; some aqueous buffers
  • Compound ClassHIF prolyl hydroxylase inhibitor / anemia agent
  • HS Code2934.99

🔬 Quality Control & Handling

  • Purity (HPLC)≥98%
  • FormCrystalline powder
  • Primary TargetHIF prolyl hydroxylase (PHD)
  • Assay ReadoutEPO; HIF-α stabilization
  • SelectivityOral HIF-PH (hypoxia mimetic)
  • Storage Condition-20°C, sealed, protect from light
  • Solution StabilityDMSO stock stable weeks at -20°C
  • ShippingRoom temp / cold chain
  • QC DocumentationCOA / HPLC / NMR / MS / MSDS
  • Pack Sizes100mg / 500mg / 1g / 5g / 10g
  • Stock StatusIn Stock
  • Use StatementResearch / investigational; not for human use

Key Molecular Targets & Pathway Nodes

Molidustat engages the molecular machinery and pathway nodes that define its research utility.

🧬 HIF-PH (PHD) 🧬 HIF-α stabilization 🧪 EPO production 💧 Iron metabolism 🦴 Erythropoiesis 🧭 CKD / anemia 🧪 Hypoxia response 🔬 HIF pathway 💧 Oxygen sensing 🧬 Gene transcription

How Molidustat Works: A Hypoxia Mimetic for Red-Cell Production

Molidustat blocks HIF-PH, stabilizing HIF-α to drive endogenous EPO and iron use

1

Inhibition of HIF Prolyl Hydroxylases

Molidustat blocks the oxygen-sensitive HIF-PH (PHD) enzymes that hydroxylate HIF-α for degradation, mimicking low-oxygen signaling.

2

Stabilization of HIF-α & EPO Induction

HIF-α accumulates and activates erythropoietin (EPO) transcription and other hypoxia-response genes.

3

Iron Mobilization & Erythroid Maturation

The HIF program lowers hepcidin and improves iron availability, maturing red cells to correct anemia of CKD — the same hypoxia-mimetic class as daprodustat.

⚖️ Molidustat vs Comparators

  • Molidustat (this product)Oral HIF-PH inhibitor; EPO induction
  • DaprodustatSister HIF-PH inhibitor
  • RoxadustatAnother HIF-PH inhibitor
  • Selective EdgeDistinct scaffold & PK within class
  • Research NicheAnemia / CKD & HIF biology

♻️ Downstream Biological Consequences

  • EnzymeHIF-PH blocked
  • TranscriptionHIF-α genes on
  • HormoneEndogenous EPO rises
  • IronHepcidin down; utilization up
  • Red cellsErythropoiesis matures
  • DiseaseCKD anemia corrected

Research Applications & Models

Molidustat is a key oral HIF-PH tool for anemia and hypoxia research.

🧭

Anemia / CKD Research

Oral HIF-PH approach to anemia of chronic kidney disease.

Anemia / CKD
🧪

HIF Pathway Studies

Probes oxygen sensing and HIF-α stabilization.

HIF
🦴

Erythropoiesis Models

Measures EPO, reticulocytes and red-cell maturation.

Erythropoiesis
💧

Iron-Metabolism Research

Investigates hepcidin and iron utilization.

Iron
🔬

HIF-PH Comparison

Benchmarked against daprodustat/roxadustat.

Comparison
🧪

Hypoxia-Mimetic Assays

Compares to EPO and related agents.

Hypoxia

Key Literature & Landmark Publications

Landmark work on molidustat and HIF-PH inhibitors for anemia.

Investigator reports. Molidustat (BAY 85-3934) HIF-PH inhibition in CKD anemia.
Landmark reference
Review. HIF prolyl hydroxylase inhibitors for anemia.
Landmark reference
Preclinical reports. Molidustat EPO induction and iron handling.
Landmark reference
Clinical literature. Oral HIF-PH agents vs ESA therapy.
Landmark reference
Structure-activity literature. Molidustat optimization.
Landmark reference

Available Sizes & Ordering

Research-grade Molidustat / BAY 85-3934 (CAS 1154028-82-6) with full QC documentation; standard packs and bulk custom quantities supported.

TierPack SizeStock StatusSuitable ForLead Time
Standard100mgIn StockHIF / anemia assaysSame/next-day ship
Medium500mgIn StockCell & pathway studiesSame/next-day ship
Large1gIn StockIn vivo anemia modelsSame/next-day ship
Bulk5gIn StockScreening & formulationQuote to confirm
Industrial10g+Made to orderProcess developmentBatch delivery

💡 Reference sizes shown above; for exact pricing and availability please contact us for a quote. Bulk orders qualify for tiered discounts.

Frequently Asked Questions (FAQ)

What is molidustat and what does it inhibit?
Molidustat (CAS 1154028-82-6), also BAY 85-3934, is an oral HIF prolyl hydroxylase (HIF-PH/PHD) inhibitor that stabilizes HIF-α to induce endogenous erythropoietin. Formula C13H14N8O2, MW 314.30.
How is molidustat like daprodustat?
Both are oral HIF-PH inhibitors that mimic hypoxia to raise EPO and improve iron use for CKD anemia; molidustat has its own scaffold (pyrimidinyl pyrazolone) and PK profile.
What models use molidustat?
Anemia of chronic kidney disease, erythropoiesis, iron-metabolism (hepcidin) and hypoxia-response research.
What readouts confirm activity?
HIF-α stabilization, EPO and reticulocyte elevation, hepcidin suppression, and hemoglobin/red-cell readouts.
How soluble is molidustat and how should it be prepared?
It is soluble in DMSO and some aqueous buffers; poorly in water. Prepare a DMSO stock, dilute into medium (final DMSO ≤0.1% v/v), and store at -20°C protected from light.
Is QC documentation provided?
Every batch ships with a Certificate of Analysis (COA) including HPLC purity, NMR structural confirmation and MS data; MSDS/SDS and Certificates of Origin are available on request.

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Research-grade Molidustat (CAS 1154028-82-6) — purity ≥98% HPLC, COA included
HIF-PH Inhibitor — request a quote today

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