4-DMA-7,8-DHF

Eutropoflavin (4′-Dimethylamino-7,8-dihydroxyflavone)

is a synthetic flavone and selective small-molecule agonist of TrkB, the main receptor of brain-derived neurotrophic factor (BDNF), which was derived from structural modification of tropoflavin (7,8-DHF)

Technical Data for 4′-Dimethylamino-7,8-dihydroxyflavone

M. Wt297.31
FormulaC17H15NO4
StorageStore at +4°C
Purity≥99% (HPLC)
CAS Number1205548-04-4
Chemical name2-[4-(dimethylamino)phenyl]-7,8-dihydroxychromen-4-one
AppearanceSolid
  Application  Research Purpose

Relative to tropoflavin, eutropoflavin possesses higher agonistic activity at TrkB, is significantly more potent than tropoflavin both in vitro and in vivo, and has a longer duration of action (peaking at 4 hours and “partially decaying” at 8~16 hours in rodents)

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