ISRIB-A17 Custom Synthesis
ISRIB-A17 ISRIB-A17, which is nearly 10-fold more potent than ISRIB-A1 Technical Data for ISRIB M. Wt 451.34 Formula C22H24Cl2N2O4 Storage Store at +4°C Purity ≥99%
Bimatoprost for eyelash growth
Bimatoprost is a prostaglandin analog/prodrug used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. It reduces intraocular pressure (IOP) by increasing the outflow of aqueous fluid from the eyes. It has also been used and prescribed off-label to lengthen eyelashes
Technical Data for Bimatoprost
| M. Wt | 415.57 |
| Formula | C25H37NO4 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 155206-00-1 |
| EINECS | 642-890-9 |
| Appearance | Powder Form |
| Smiles | CCNC(=O)CCCC=CCC1C(CC(C1C=CC(CCC2=CC=CC=C2)O)O)O |
Bimatoprost (marketed in the U.S., Canada and Europe by Allergan, under the trade name Lumigan) is a prostaglandin analog/prodrug used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. It reduces intraocular pressure (IOP) by increasing the outflow of aqueous fluid from the eyes.In December 2008, the indication to lengthen eyelashes was approved by the U.S. Food and Drug Administration (FDA); the cosmetic formulation of bimatoprost is sold as Latisse.In 2008-2011, at least three case series suggested that bimatoprost has the ability to reduce adipose (fat) tissue
Specification
Items | Specifications | Results |
Appearance | White to almost white powder | White powder |
Identification | HPLC retention time of sample complies with that of known sample | Complies |
Specific rotation | [a]D20: +33.0°~+37.0°(C=1.0,CH3CN) | +36.0° |
Water | ≤1.0% | 0.31% |
Related substances
| 15R-Bimatoprost: ≤0.30% Bimatoprostfree acid: ≤0.10% 5,6-trans-Bimatoprost: ≤0.50% Any other single impurity: ≤0.10% Total other impurities: ≤ 0.50% | Not detected Not detected 0.07% 0.05% 0.18% |
Residual solvents
| Ter-Butylmethyl ether: ≤ 5000ppm Ethanol: ≤5000ppm N-Hexane: ≤ 290ppm Ethyl acetate: ≤5000ppm | Not detected Not detected 16.13ppm 18.92ppm |
Purity | ≥99.5% | 99.82% |
Usage
- 1) Treat of glaucoma
Bimatoprost is used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.
It reduces intraocular pressure (IOP) by increasing the outflow of aqueous fluid from the eyes.
- 2) For growth of lashes as cosmetic
It has also been used and prescribed off-label to lengthen eyelashes
- 3) For growth of hair
As the FASEB Journal reporting, most of our client bought for the research of hair regrow. they estimate that this will be the next big use for bimatoprost around the world.
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