GTS 21 dihydrochloride (CAS 156223-05-1)

GTS21 (DMXBA) is a derivative of the natural product anabaseine that acts as a partial agonist at neural nicotinic acetylcholine receptors.

Technical Data for GTS-21

 

M. Wt381.3
FormulaC19H22Cl2N2O2
StorageStore at +4°C
Purity≥99% (HPLC)
CAS Number156223-05-1
AppearancePowder Form
SolubilitySoluble to 50 mM in DMSO
Chemical name

3-[(2,4-Dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-2,3′-bipyridine dihydrochloride

GTS 21 dihydrochloride is a partial agonist of α7 nicotinic acetylcholine receptors (nAChRs); also a weak α4β2 and 5-HT3 antagonist at micromolar concentrations. Exhibits improved sensory inhibition in DBA/2 mice following both acute and chronic administration. Also shown to improve memory in several animal models; facilitates hippocampal long-term potentiation. Also has anti-inflammatory effects independent of α7 nAChRs.

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