(-)-Huperzine A is a potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE) with Ki of 7 nM, exhibiting 200-fold more selectivity for G4 AChE over G1 AChE. Also acts as an NMDA receptor antagonist. Phase 4.
Technical Data for Huperzine A
M. Wt | 242.32 |
Formula | C15H18N2O |
Storage | Store at +4°C |
Purity | 98% & 1% |
CAS Number | 120786-18-7 |
Synonyms | (1R,9S,13E)- 1-Amino- 13-ethylidene- 11-methyl- 6-azatricyclo[7.3.1.02,7] trideca- 2(7),3,10- trien- 5-one |
Solublity | Soluble in 5%TFA. Insoluble in water and DMSO |
Appearance | Off-white solid(98%+) Brown Powder (1%) |
What are nootropics
Nootropics also referred to as smart drugs, memory enhancers, neuro enhancers, cognitive enhancers, and intelligence enhancers, are drugs, supplements, nutraceuticals, and functional foods that purportedly improve mental functions such as cognition, memory, intelligence, motivation, attention, and concentration.
- Nootropics are thought to work by altering the availability of the brain’s supply of neurochemicals (neurotransmitters, enzymes, andhormones), by improving the brain’s oxygen supply, or by stimulating nerve growth.
Racetams
- The racetams are structurally similar compounds, such as pramiracetam, oxiracetam, coluracetam, and aniracetam, which are often marketed as cognitive enhancers and sold over-thecounter. Racetams are often referred to as nootropics, but this property of the drug class is not well established. The racetams have a poorly understoodmechanisms of action
Features
Greater penetration of the blood-brain barrier, higher oral bioavailability, and longer AChE inhibition relative to tacrine, donepezil, and rivastigmine.