Nutrabiotech Arecoline Hydrobromide 98% 10G Powder, high purity Arecoline HBr powder, muscarinic acetylcholine receptor agonist, cholinergic pathway modulator, oral fibrosis and neurocognitive research raw material

Arecoline Hydrobromide CAS 300-08-3 98% Purity Cholinergic Agonist Powder

High purity Arecoline Hydrobromide powder CAS 300-08-3 with 98% HPLC purity. Natural areca nut alkaloid and potent cholinergic agonist for pharmacological research, factory bulk supply, full certificates and fast global delivery.
Category: Tags: , , , , , , ,
Arecoline Hydrobromide (CAS 300-08-3) Muscarinic Acetylcholine Agonist | Cholinergic Research

Arecoline Hydrobromide CAS 300-08-3
Muscarinic Acetylcholine Receptor Agonist

Arecoline hydrobromide (CAS 300-08-3) is the hydrobromide salt of arecoline, a natural alkaloid from areca nut and a muscarinic acetylcholine receptor agonist (partial agonist at M1/M2/M3). It stimulates cholinergic signaling in cognition, gastrointestinal motility and parasympathetic research. The HBr salt improves handling and solubility. Formula C8H14BrNO2, MW 236.11. Research-grade with COA.

ArecolineMuscarinicAcetylcholineCholinergicArecoline HBrCognitionGI MotilityM1/M2/M3
Request a Quote Technical Specs
236.11
MW (C8H14BrNO2)
≥98%
Purity (HPLC)
M1/M2/M3
Muscarinic agonist

Molecular Information

Name: Arecoline Hydrobromide
CAS: 300-08-3
Formula: C8H14BrNO2
MW: 236.11 g/mol
Class: Muscarinic ACh receptor agonist
Core: Tetrahydropyridine carboxylate (HBr salt)
Target: Muscarinic ACh receptors (M1/M2/M3)
Activity: Cholinergic stimulation
MP: Not firmly reported
Appearance: White to off-white crystalline powder
Synonyms: Arecoline HBr
Storage: -20°C, protect from light
300-08-3
🧪
CAS Number
236.11
⚖️
Molecular Weight
Muscarinic Agonist
🎯
Primary Activity
≥98%
✅
Purity

Product Technical Specifications

Complete physicochemical properties and QC parameters for Arecoline Hydrobromide (CAS 300-08-3)

📋 Physicochemical Properties

  • Product NameArecoline Hydrobromide
  • IUPAC Namemethyl 1-methyl-3,6-dihydro-2H-pyridine-3-carboxylate;hydrobromide
  • CAS Number300-08-3
  • SynonymsArecoline hydrobromide; Arecoline HBr
  • Molecular FormulaC8H14BrNO2
  • Molecular Weight236.11 g/mol
  • SourceBotanical alkaloid (areca) / semi-synthetic
  • AppearanceWhite to off-white crystalline powder
  • Water SolubilityGood (hydrobromide salt)
  • Organic SolubilityDMSO; ethanol
  • Compound ClassMuscarinic acetylcholine receptor agonist
  • HS Code2934.99

🔬 Quality Control & Handling

  • Purity (HPLC)≥98%
  • FormCrystalline powder (hydrobromide salt)
  • Primary TargetMuscarinic ACh receptors (M1/M2/M3)
  • Assay ReadoutCholinergic / motility readouts
  • SelectivityPartial muscarinic (M1/M2/M3) agonist
  • Storage Condition-20°C, sealed, protect from light
  • Solution StabilityAqueous/DMSO stock stable at -20°C
  • ShippingRoom temp / cold chain
  • QC DocumentationCOA / HPLC / NMR / MS / MSDS
  • Pack Sizes100mg / 500mg / 1g / 5g / 10g
  • Stock StatusIn Stock
  • Use StatementResearch use only; not for human/clinical use

Key Molecular Targets & Pathway Nodes

Arecoline Hydrobromide engages the molecular machinery and pathway nodes that define its research utility.

🧬 Muscarinic ACh (M1) 🧬 Muscarinic ACh (M2) 🧬 Muscarinic ACh (M3) 🧪 Cholinergic system 💧 Parasympathetic pathways 🧭 Cognition 🍲 GI motility 🔬 Receptor profiling 🦴 Neurotransmission 🧬 Acetylcholine

How Arecoline Works: Stimulating the Cholinergic System

Arecoline activates muscarinic acetylcholine receptors, driving parasympathetic and cognitive effects

1

Agonism of Muscarinic ACh Receptors

Arecoline is a muscarinic acetylcholine receptor agonist (partial agonist at M1/M2/M3 subtypes), mimicking the endogenous neurotransmitter acetylcholine.

2

Activation of Cholinergic & Parasympathetic Pathways

Receptor activation stimulates cholinergic neurotransmission and parasympathetic responses — including smooth-muscle and secretory activity.

3

Cognitive, Motor & GI Phenotypes

In research, arecoline is used to probe cognition, attention and gastrointestinal motility, and as a cholinergic probe in pharmacology and natural-product studies.

⚖️ Arecoline Hydrobromide vs Comparators

  • Arecoline (this product)Natural muscarinic (M1/M2/M3) agonist
  • PilocarpineMuscarinic agonist (M3-focused)
  • BethanecholMuscarinic agonist (GI/bladder)
  • Selective EdgePartial agonist; natural alkaloid
  • Research NicheCholinergic & cognition / GI

♻️ Downstream Biological Consequences

  • ReceptorMuscarinic M1/M2/M3 on
  • NeuroCholinergic transmission up
  • ParasympatheticSecretory / motor effects
  • CognitionAttention / memory readouts
  • GIMotility increased
  • ModelsCholinergic pharmacology

Research Applications & Models

Arecoline is a classic cholinergic probe for cognition, motility and receptor studies.

🧭

Cholinergic / Cognition Research

Probes acetylcholine signaling in learning, memory and attention models.

Cognition
🧬

Muscarinic Receptor Profiling

Benchmarks M1/M2/M3 agonism and SAR.

Muscarinic
🍲

GI Motility Models

Studied for parasympathetic smooth-muscle and motility effects.

GI Motility
🧪

Parasympathomimetic Studies

Investigates parasympathetic physiology.

Parasympathetic
🔬

Natural-Product Pharmacology

Areca / betel alkaloid research and toxicology.

Natural
🦴

Receptor Assay Development

Functional muscarinic assays and screening.

Assays

Key Literature & Landmark Publications

Landmark work on arecoline, muscarinic receptors and cholinergic pharmacology.

Investigator reports. Arecoline muscarinic agonism and cholinergic effects.
Landmark reference
Review. Areca alkaloids and muscarinic pharmacology.
Landmark reference
Preclinical reports. Arecoline in cognition and GI motility.
Landmark reference
Receptor studies. Arecoline M1/M2/M3 selectivity.
Landmark reference
Toxicology literature. Arecoline natural-product safety.
Landmark reference

Available Sizes & Ordering

Research-grade Arecoline Hydrobromide (CAS 300-08-3) with full QC documentation; standard packs and bulk custom quantities supported.

TierPack SizeStock StatusSuitable ForLead Time
Standard100mgIn StockReceptor / cholinergic assaysSame/next-day ship
Medium500mgIn StockCell & binding studiesSame/next-day ship
Large1gIn StockIn vivo modelsSame/next-day ship
Bulk5gIn StockScreening & formulationQuote to confirm
Industrial10g+Made to orderProcess developmentBatch delivery

💡 Reference sizes shown above; for exact pricing and availability please contact us for a quote. Bulk orders qualify for tiered discounts.

Frequently Asked Questions (FAQ)

What is arecoline hydrobromide and what does it do?
Arecoline hydrobromide (CAS 300-08-3) is the hydrobromide salt of arecoline, a natural areca-nut alkaloid and muscarinic acetylcholine receptor agonist (partial agonist at M1/M2/M3) that stimulates cholinergic signaling. Formula C8H14BrNO2, MW 236.11.
Why is it supplied as the hydrobromide?
The hydrobromide salt improves aqueous solubility and handling/stability versus the free base, which is convenient for assay preparation.
What is arecoline researched for?
Cognition and cholinergic neurotransmission, muscarinic-receptor profiling, gastrointestinal motility and parasympathetic physiology.
What readouts confirm activity?
Muscarinic receptor binding/activation assays, acetylcholine-mediated responses, and GI-motility / behavioral readouts.
How soluble is arecoline HBr and how should it be prepared?
As a salt it is water-soluble and also dissolves in DMSO/ethanol. Prepare aqueous or DMSO stocks and store at -20°C protected from light.
Is QC documentation provided?
Every batch ships with a Certificate of Analysis (COA) including HPLC purity, NMR structural confirmation and MS data; MSDS/SDS and Certificates of Origin are available on request.

Need Arecoline Hydrobromide for Your Research?

Research-grade Arecoline Hydrobromide (CAS 300-08-3) — purity ≥98% HPLC, COA included
Muscarinic (M1/M2/M3) Agonist — request a quote today

Request a Quote →

Related products