NutraBiotech Key Products: Trans ISRIB, NRH, ISRIB A-17 & 40+ Premium Research Compounds
Manufacturer-direct research compounds engineered to the highest purity standards. From the most potent NAD+ precursor to ultra-potent integrated stress response inhibitors — discover NutraBiotech's complete product portfolio at competitive wholesale pricing.
NutraBiotech's 3 Flagship Products
Industry-leading research compounds that define the cutting edge of integrated stress response inhibition and NAD+ precursor technology. Manufactured to pharmaceutical-grade standards with full analytical documentation.
Trans ISRIB (Integrated Stress Response Inhibitor)
Trans ISRIB (trans-N,N'-(Cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide)) is a groundbreaking small molecule that potently and selectively inhibits the integrated stress response (ISR). Discovered at the University of California, San Francisco by the Walter lab, ISRIB works downstream of eIF2α phosphorylation by stabilizing the active eIF2B complex — effectively restoring global protein synthesis in stressed cells without interfering with upstream kinase signaling. Its ability to readily cross the blood-brain barrier (8-hour half-life) and enhance long-term memory in preclinical models has made it one of the most sought-after research compounds in neurobiology and cognitive science.
NRH (Dihydronicotinamide Riboside — The Most Potent NAD+ Precursor)
NRH (Dihydronicotinamide Riboside) is the reduced form of Nicotinamide Riboside (NR) and the most potent NAD+ precursor ever discovered. First characterized as a NAD+ concentration enhancer in 2019 by researchers at Weill Cornell Medicine, NRH exploits a completely unique metabolic shortcut through adenosine kinase (ADK) — an enzyme pathway entirely independent of the NRK1/NRK2 and NAMPT systems that constrain all other NAD+ precursors. This ADK-dependent pathway enables NRH to increase intracellular NAD+ 2.5 to 10-fold more than equivalent doses of NR or NMN, often reaching peak levels within just 1 hour. NRH crosses the blood-brain barrier, achieves broad tissue distribution, and has demonstrated significant metabolic benefits in preclinical studies including improved glucose homeostasis and lipid metabolism in diet-induced obese models.
ISRIB A-17 (ISR-IN-1 / Ultra-Potent Integrated Stress Response Inhibitor)
ISRIB A-17 (also known as ISR-IN-1, trans-ISRIB A17) represents the pinnacle of bis-O-arylglycolamide integrated stress response inhibitor optimization. Through extensive structure-activity relationship (SAR) studies by the Walter and Renslo laboratories at UCSF, the addition of para-fluoro and meta-chloro substituents on both aryl rings produced an analog approximately 8–10 times more potent than the original ISRIB trans-isomer — lowering the EC50 from 5 nM to an extraordinary 0.6 nM in the ATF4-luciferase reporter assay. Like ISRIB, ISRIB A-17 acts by stabilizing the active eIF2B dimer complex downstream of eIF2α phosphorylation, but its enhanced binding affinity at the symmetrical eIF2B interface translates to dramatically improved cellular potency. The functional two-fold symmetry of ISRIB A-17 reflects the two-fold symmetric nature of its eIF2B target — representing one of the most elegant examples of structure-guided drug design in ISR pharmacology.
Flagship Product Comparison at a Glance
| Property | Trans ISRIB | NRH | ISRIB A-17 |
|---|---|---|---|
| Class | ISR / PERK Inhibitor | NAD+ Precursor | ISR / eIF2B Stabilizer |
| CAS Number | 1597403-47-8 | — (Dihydronicotinamide Riboside) | 1628478-15-8 |
| Molecular Weight | 451.34 g/mol | — | 487.32 g/mol |
| Potency | IC50 5 nM | 2.5–10× NAD+ vs NR/NMN | EC50 0.6 nM |
| Mechanism | eIF2B stabilization; anti-eIF2α-P | ADK → NMNH → NADH → NAD+ | Enhanced eIF2B dimer stabilization |
| BBB Penetrant | ✔ Yes | ✔ Yes | ✔ Yes |
| Primary Research Use | Neurobiology, memory, ER stress | NAD+ biology, metabolism, aging | Ultra-potent ISR pathway studies |
| Purity (Min) | ≥98% HPLC | ≥98% HPLC | ≥98% HPLC |
Complete Product Categories
40+ premium research compounds organized into four specialized categories. Every product undergoes rigorous quality control with full analytical documentation provided.
01. Research Chemicals
High-purity research compounds for laboratory and scientific investigation. These chemical substances are intended exclusively for in vitro research and laboratory study purposes — not for human or veterinary use. Each product is verified by HPLC, NMR, and mass spectrometry with batch-specific Certificates of Analysis.
02. Nootropics
Nootropics — also known as "smart drugs" and "cognitive enhancers" — are compounds that may improve cognitive function, particularly executive function, memory, creativity, or motivation in healthy individuals. While many substances are purported to enhance cognition, research remains at preliminary stages and the effects of most nootropic compounds have not been fully established. NutraBiotech supplies these compounds for research purposes only.
03. Natural Products
Natural products are chemical compounds or substances produced by living organisms — found in nature. In the broadest sense, natural products include any substance produced by life. These compounds can also be prepared by chemical synthesis (both semi-synthesis and total synthesis) and have played a central role in the development of organic chemistry by providing challenging synthetic targets. The term "natural product" has also been extended for commercial purposes to refer to cosmetics, dietary supplements, and foods produced from natural sources without artificial additives.
04. Research for Anti-Hairloss
Research compounds targeting hair loss pathways, including androgen receptor antagonists, prostaglandin D2 receptor (CRTh2) inhibitors, Wnt/β-catenin pathway activators, and 5α-reductase inhibitors. These compounds are supplied for laboratory research into androgenic alopecia and related dermatological conditions. Minoxidil (Rogaine) remains the best-established topical treatment for hair loss — applied once daily (women) or twice daily (men) to the scalp. Products containing minoxidil have helped many individuals regrow hair or slow the rate of hair loss. NutraBiotech supplies these compounds strictly for research purposes.
Why Choose NutraBiotech?
Direct manufacturer. Pharmaceutical-grade quality. Competitive pricing. Full transparency.
Direct Manufacturer
We are the manufacturer — not a reseller. Vertical integration means full control over synthesis, purification, and quality assurance. No middlemen, no markups, no delays.
Full Analytical Documentation
Every batch is independently verified with HPLC, NMR, and mass spectrometry. Complete Certificate of Analysis (COA) provided with each order — no exceptions.
Rigorous Purity Standards
≥98% purity (HPLC-verified) is our baseline standard. ≥99% purity available for select compounds. Batch-specific data, not manufacturer claims — verified results.
Price Advantage — 30–50% Lower
Direct-to-customer manufacturing eliminates distributor and reseller margins. We deliver pharmaceutical-grade research compounds at prices 30–50% below comparable suppliers.
Best Value GuaranteedBulk & Wholesale Orders
Volume discounts for research institutions, formulators, and commercial buyers. Custom synthesis, private labeling, and OEM services available upon request.
Worldwide Shipping
Temperature-controlled logistics with oxygen-protected packaging for moisture-sensitive compounds like NRH. Secure, tracked shipping to research facilities worldwide.
How to Order — Simple 4-Step Process
Browse & Select
Choose your compounds from our 40+ product catalog. Check specifications, purity grades, and available quantities.
Request a Quote
Contact us with your compound(s), quantity, and purity requirements. Receive a personalized quotation within 24 hours.
Confirm & Pay
Review and confirm your order. Secure payment via our supported methods. Full proforma invoice provided.
Receive & Verify
Your order ships with full documentation (COA, HPLC, NMR, MS, heavy metals, residual solvents). Track your shipment in real time.
🚀 Ready to Source Premium Research Compounds?
Whether you're advancing ISR pathway research, developing NAD+ formulations, or building a next-generation nootropic stack — NutraBiotech delivers the quality, purity, and value you need. Contact us today for a personalized quote on any of our 40+ compounds, including Trans ISRIB, NRH, and ISRIB A-17.
Frequently Asked Questions
NutraBiotech's three flagship products are:
- Trans ISRIB (CAS 1597403-47-8) — A potent PERK inhibitor with IC50 5 nM that crosses the blood-brain barrier and enhances cognitive function. Works by stabilizing the eIF2B complex and reversing the effects of eIF2α phosphorylation.
- NRH (Dihydronicotinamide Riboside) — The strongest known NAD+ precursor delivering 2.5–10× greater NAD+ elevation than NR or NMN through a unique adenosine kinase (ADK) pathway. Broad tissue distribution including brain penetration.
- ISRIB A-17 (ISR-IN-1) (CAS 1628478-15-8) — An ultra-potent integrated stress response inhibitor with EC50 0.6 nM, approximately 10× more potent than Trans ISRIB. SAR-optimized with para-fluoro and meta-chloro substituents for enhanced eIF2B binding.
All three are manufactured to pharmaceutical-grade standards (≥98% HPLC purity) with full analytical documentation.
NutraBiotech offers 40+ research compounds organized into four specialized categories:
- Research Chemicals — ISRIB, Tideglusib, GS-441524, Ebselen, C60, Fluorescein, NMN, VX-661, PKI-587
- Nootropics — NSI-189, J147, GTS-21, Sunifiram, Coluracetam, IDRA-21, PRL-8-53, Theacrine, Nefiracetam, GLYX-13, Fasoracetam
- Natural Products — 7,8-Dihydroxyflavone, Urolithin A, Shikonin, Epicatechin, Laxogenin, Forskolin, Huperzine A, Urolithin B, Urolithin C
- Research for Anti-Hairloss — CB-03-01, WAY-316606, RU-58841, Finasteride, Minoxidil, Fevipiprant, OC000459, Setipiprant, SM04554, Equol, Dutasteride
Trans ISRIB (CAS 1597403-47-8) and ISRIB A-17 (CAS 1628478-15-8) are both bis-O-arylglycolamide integrated stress response (ISR) inhibitors, but ISRIB A-17 is significantly more potent. The key differences:
- Potency: Trans ISRIB has IC50/EC50 of 5 nM; ISRIB A-17 achieves EC50 of 0.6 nM — approximately 8–10× more potent.
- Structure: Trans ISRIB contains para-chloro substituents on both aryl rings. ISRIB A-17 substitutes these with para-fluoro and meta-chloro substituents, enhancing target binding at the eIF2B dimer interface.
- Development: ISRIB A-17 was produced through extensive SAR optimization by the Walter and Renslo labs at UCSF, representing the most potent analog in the ISRIB series.
- Molecular Weight: Trans ISRIB = 451.34 g/mol; ISRIB A-17 = 487.32 g/mol.
Yes. NutraBiotech is a direct manufacturer and supplier — not a reseller. This vertical integration enables highly competitive wholesale and bulk pricing across our entire product portfolio. Volume discounts are available for:
- Research institutions and academic laboratories
- Supplement formulators and nutraceutical companies
- Pharmaceutical and biotech companies
- Commercial buyers and distributors
Contact our sales team with your specific compound, quantity, and purity requirements for a personalized quote. Minimum order quantities vary by product.
Every NutraBiotech product ships with comprehensive quality documentation including:
- Certificate of Analysis (COA) — Batch-specific purity data (HPLC)
- HPLC Chromatogram — High-Performance Liquid Chromatography trace
- NMR Spectra — 1H and 13C Nuclear Magnetic Resonance for structural confirmation
- Mass Spectrometry (MS) — Molecular weight and fragmentation data
- Heavy Metals Testing — ICP-MS analysis
- Residual Solvents Report — GC-MS analysis
All products meet ≥98% purity as standard, with ≥99% available upon request for select compounds.
NRH is sensitive to oxygen, light, heat, and acidic pH. NutraBiotech employs a comprehensive stability preservation protocol:
- Nitrogen Atmosphere Packaging — All NRH is packaged under inert nitrogen gas to prevent oxidative degradation.
- Oxygen Absorbers & Desiccants — Included in every container to maintain an oxygen-free, moisture-free environment.
- Light-Protected Containers — Amber glass vials or opaque packaging blocks UV and visible light exposure.
- Temperature-Controlled Logistics — Cold-chain shipping options available; recommendations provided based on destination and transit time.
- Stability Data Provided — Batch-specific stability testing data included with COA documentation.
Proper storage after receipt: powder at −20°C in airtight, light-protected containers; solutions at −80°C with minimal freeze-thaw cycles.
Yes. As a direct manufacturer with in-house synthesis capabilities, NutraBiotech offers custom synthesis services for compounds not currently listed in our catalog. Whether you need a specific analog, a modified structure, or a compound at a particular purity grade, our chemistry team can evaluate feasibility and provide a quotation. Services include:
- Custom organic synthesis (milligram to kilogram scale)
- Process optimization and scale-up
- Analytical method development and validation
- Private labeling and OEM manufacturing
- Stability studies and formulation support
Contact our technical team with your specific requirements for a feasibility assessment and quotation.
No. All NutraBiotech products are classified as research chemicals and are intended exclusively for laboratory research and scientific investigation purposes. They are not intended for human or veterinary use, diagnosis, treatment, or prevention of any disease. Products have not been evaluated or approved by the FDA, EMA, or any other regulatory authority for human consumption. By purchasing from NutraBiotech, customers acknowledge that products are for research use only and agree to comply with all applicable laws and regulations regarding the handling and use of research chemicals.
All products sold by NutraBiotech are intended strictly for laboratory research and scientific investigation purposes. These products are NOT intended for human consumption, veterinary use, or therapeutic/diagnostic applications. None of the products listed on this page have been evaluated or approved by the FDA, EMA, or any other regulatory authority for the diagnosis, treatment, cure, or prevention of any disease. The information provided on this page is for informational and educational purposes only and does not constitute medical advice. Purchasers are solely responsible for compliance with all applicable local, national, and international laws and regulations regarding the purchase, handling, storage, and use of research chemicals. NutraBiotech shall not be held liable for any misuse of its products.