Nutrabiotech Jatrorrhizine 98% 1G Powder, high purity Jatrorrhizine alkaloid powder, natural multi-target bioactive compound, metabolic regulator, neuroprotective & anti-tumor research raw material

CAS 3621-38-3 Jatrorrhizine Powder Natural Berberine Alkaloid for Neuroprotection and Anti-Inflammation Research

Premium 98% Jatrorrhizine crystalline powder CAS 3621-38-3, natural protoberberine alkaloid with neuroprotective, anti-inflammatory and lipid-regulating bioactivities. In stock for neuroscience and metabolic pharmacology research.
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Jatrorrhizine (CAS 3621-38-3) Isoquinoline Alkaloid | Anti-Inflammatory, Anti-Diabetic & Anti-Tumor Phytochemical from Coptis / Tinospora

Jatrorrhizine CAS 3621-38-3
Isoquinoline Berberine-Type Alkaloid (Anti-Inflammatory & Anti-Metabolic)

Jatrorrhizine (CAS 3621-38-3) is a quaternary isoquinoline (berberine-type) alkaloid found in Coptis, Tinospora and other medicinal plants. It exhibits anti-inflammatory, antimicrobial, anti-diabetic and anti-tumor activities and modulates PI3K/Akt/mTOR and topoisomerase pathways. Molecular formula C20H20NO4 (free base), MW 338.38; chloride salt C20H20ClNO4, MW 373.83. Research-grade with COA.

Isoquinoline Alkaloid Berberine-Type Anti-Inflammatory Anti-Diabetic Anti-Tumor Phytochemical Coptis / Tinospora PI3K/Akt/mTOR
Request a Quote Technical Specs
338.38
MW (C20H20NO4)
≥95%
Purity (HPLC)
Alkaloid
Berberine-type

Molecular Information

Name: Jatrorrhizine
CAS: 3621-38-3
Formula: C20H20NO4 (base)
MW: 338.38 g/mol
Class: Isoquinoline (berberine-type)
Core: Trimethoxy-berbinium quaternary ammonium
Source: Coptis / Tinospora
Salt: Chloride 373.83 g/mol
Appearance: Off-white to beige powder
Synonyms: Neprotine / Yatrorizine
Storage: 2-8 C
🧪
CAS Number
3621-38-3
⚖️
Molecular Weight
338.38
🎯
Primary Activity
Alkaloid / Anti-Inflam.
✅
Purity
≥95%

Product Technical Specifications

Complete physicochemical properties and QC parameters for Jatrorrhizine (CAS 3621-38-3)

📋 Physicochemical Properties

  • Product NameJatrorrhizine
  • IUPAC Core7,8,13,13a-tetradehydro-3-hydroxy-2,9,10-trimethoxyberbinium
  • CAS Number3621-38-3
  • SynonymsNeprotine; Yatrorizine; Jatrorhizine
  • Molecular FormulaC20H20NO4 (free base)
  • Molecular Weight338.38 g/mol
  • Salt FormChloride C20H20ClNO4, MW 373.83
  • SourceCoptis chinensis, Tinospora sagittata
  • AppearanceOff-white to beige powder
  • Melting PointNot reported
  • Water SolubilityChloride salt water-soluble; base limited
  • Organic SolubilityMethanol
  • Compound ClassIsoquinoline / berberine-type alkaloid
  • HS Code2939.90

🔬 Quality Control & Handling

  • Purity (HPLC)≥95%
  • FormPowder (chloride salt commonly supplied)
  • Primary TargetInflammation & metabolic signaling nodes
  • Pathway ReadoutPI3K/Akt/mTOR modulation; topoisomerase inhibition
  • MicrobiologyLow bioburden, suitable for cell studies
  • Storage Condition2-8 C, sealed, protect from light
  • Solution StabilityPrepare fresh; protect from light
  • ShippingCool pack / room temperature
  • QC DocumentationCOA / HPLC / NMR / MS / MSDS
  • Pack Sizes1g / 5g / 10g / 100g / 1KG
  • Stock StatusIn Stock
  • Use StatementResearch use only; not for human/clinical use

Key Molecular Targets & Pathway Nodes

As a berberine-type alkaloid, jatrorrhizine's reach spans inflammatory signaling, metabolic pathways and proliferation control — overlapping but distinct from its sister alkaloid berberine.

🧬 PI3K/Akt/mTOR Axis 🔥 NF-kB / Inflammatory Cytokines 🦠 Microbial Targets (antimicrobial) 🧬 Topoisomerase I/II (inhibited) ⚙️ AMPK / Glucose Uptake 🩸 Insulin Signaling 🧫 Apoptosis & Cell Cycle 🧬 COX-2 / iNOS 🛡️ Oxidative Stress 🧬 Mitochondrial Pathway 🔬 Anti-Diabetic Models 🧫 Anti-Tumor

How Jatrorrhizine Works: Multi-Target Alkaloid Pharmacology

A berberine-type scaffold that concurrently dampens inflammation, reprograms metabolism and restricts proliferation

1

PI3K/Akt/mTOR Modulation

Jatrorrhizine interferes with the PI3K/Akt/mTOR cascade — a central growth and survival axis — blunting downstream phosphorylation that drives proliferation and metabolic dysregulation, analogous to but mechanistically distinct from berberine.

2

NF-kB & Inflammatory Suppression

It attenuates NF-kB activation and the downstream burst of pro-inflammatory cytokines (TNF-alpha, IL-6) and enzymes (COX-2, iNOS), contributing to its anti-inflammatory profile in models of colitis, arthritis and metabolic inflammation.

3

Topoisomerase & Apoptotic Engagement

Reported topoisomerase I/II inhibitory activity and mitochondrial/intrinsic apoptotic engagement help explain anti-tumor findings, where jatrorrhizine reduces cancer-cell viability and promotes apoptosis across several lines.

⚖️ Jatrorrhizine vs Berberine vs Palmatine

  • Jatrorrhizine (this product)Berberine-type; anti-inflammatory & anti-metabolic
  • BerberineBest-studied sister alkaloid; AMPK activator
  • PalmatineStructurally related; similar antimicrobial profile
  • Shared ScaffoldIsoquinoline berbinium quaternary ammonium
  • Research UseComparative phytochemical / multi-target studies
  • DistinctionSubstitution pattern shifts selectivity & potency

♻️ Downstream Biological Consequences

  • InflammationReduced TNF-alpha, IL-6, COX-2, iNOS
  • MetabolismImproved glucose handling; AMPK modulation
  • ProliferationPI3K/Akt/mTOR dampening
  • ApoptosisMitochondrial pathway engagement
  • MicrobesAntimicrobial activity
  • TumorReduced viability in cancer lines

Research Applications & Models

Jatrorrhizine sits at the intersection of natural-product pharmacology, metabolic disease and oncology.

🌿

Anti-Inflammatory Models

Studied in colitis, arthritis and metabolic-inflammation models where it suppresses NF-kB and cytokine/enzyme output (TNF-alpha, IL-6, COX-2, iNOS).

NF-kB
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Anti-Diabetic / Metabolic

Investigated for glucose-lowering, insulin-sensitizing and AMPK-modulating effects in diabetes and insulin-resistance models, consistent with berberine-type activity.

Glucose / AMPK
🦠

Antimicrobial Research

Shown to inhibit bacteria and fungi in phytochemical screens; studied as a natural-product lead against resistant pathogens.

Antimicrobial
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Anti-Tumor Studies

Reported topoisomerase inhibition and apoptosis induction make it a candidate in several cancer-cell models probing natural-product cytotoxicity.

Topo / Apoptosis
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PI3K/Akt/mTOR Probing

Used to dissect how berberine-type alkaloids modulate the PI3K/Akt/mTOR axis in proliferation and metabolism research.

PI3K/mTOR
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Natural-Product / Botanical

A marker/reference compound for Coptis, Tinospora and related botanicals; used in authentication, standardization and comparative alkaloid studies.

Botanical QC
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Multi-Target Pharmacology

Deployed to map polypharmacology of isoquinoline alkaloids across inflammation, metabolism and oncology in a single scaffold.

Polypharmacology
🔬

Hepatoprotective Models

Explored for liver-protective effects against chemically induced injury, where it reduces oxidative and inflammatory damage.

Liver

Key Literature & Landmark Publications

Selected references on isoquinoline alkaloids and jatrorrhizine pharmacology.

Kong W, et al. Berberine and its analogs: a multi-target natural product class. (review of berberine-type alkaloids).
Landmark reference
Tan W, et al. Anti-inflammatory and anti-diabetic activities of Coptis alkaloids. (jatrorrhizine context).
Landmark reference
Lee SI, et al. Isoquinoline alkaloids and PI3K/Akt/mTOR modulation.
Landmark reference
Natural-product report. Jatrorrhizine: antimicrobial and anti-tumor properties.
Landmark reference
Phytochemistry reference. Tinospora / Coptis alkaloid profiling.
Landmark reference

Available Sizes & Ordering

Research-grade Jatrorrhizine (CAS 3621-38-3) with full QC documentation; standard packs and bulk custom quantities supported.

TierPack SizeStock StatusSuitable ForLead Time
Standard1gIn StockPhytochemical / cell screeningSame/next-day ship
Medium5gIn StockAnti-inflammatory & metabolic modelsSame/next-day ship
Large10gIn StockAnti-tumor & natural-product studiesSame/next-day ship
Bulk100gIn StockBotanical standardization / formulationQuote to confirm
Industrial1KGMade to orderPilot/production scale, CMO supplyBatch delivery

💡 Reference sizes shown above; for exact pricing and availability please contact us for a quote. Bulk orders qualify for tiered discounts.

Frequently Asked Questions (FAQ)

What is jatrorrhizine?
Jatrorrhizine (CAS 3621-38-3) is a quaternary isoquinoline (berberine-type) alkaloid found in medicinal plants such as Coptis chinensis and Tinospora sagittata. Like its better-known relative berberine, it shows anti-inflammatory, antimicrobial, anti-diabetic and anti-tumor activities and is reported to modulate the PI3K/Akt/mTOR axis and inhibit topoisomerase. Free-base formula C20H20NO4, MW 338.38; the commonly supplied chloride salt is C20H20ClNO4, MW 373.83.
How does jatrorrhizine relate to berberine?
Both are berberine-type isoquinoline alkaloids sharing the berbinium core, but differ in substituents, which shifts potency and selectivity. Berberine is the most intensively studied (notably as an AMPK activator), whereas jatrorrhizine is investigated for its own anti-inflammatory, metabolic and cytotoxic profile. Researchers often compare them directly in multi-target natural-product studies.
What molecular pathways does it affect?
It is best described as a multi-target alkaloid: it dampens the PI3K/Akt/mTOR survival axis, suppresses NF-kB-driven inflammation (TNF-alpha, IL-6, COX-2, iNOS), modulates AMPK and glucose handling, and shows topoisomerase I/II inhibition with mitochondrial apoptotic engagement in tumor cells.
Is jatrorrhizine soluble and how should it be prepared?
The free base is poorly water-soluble; the chloride salt is water-soluble and also dissolves in methanol. For cell assays prepare fresh stocks (often in methanol or mild aqueous acid) and protect from light; store the solid at 2-8 C. Confirm the exact salt form on your COA, since base and chloride differ in molecular weight (338.38 vs 373.83).
In which models is jatrorrhizine used?
It appears in anti-inflammatory (colitis, arthritis, metabolic inflammation), anti-diabetic/insulin-resistance, antimicrobial, anti-tumor (topoisomerase/apoptosis) and botanical-standardization research, and as a comparator within the berberine-type alkaloid family.
Is QC documentation provided?
Every batch ships with a Certificate of Analysis (COA) including HPLC purity, NMR structural confirmation and MS data. MSDS/SDS, residual-solvent data and Certificates of Origin are available on request. Sample evaluation is available for qualified institutions — please contact us.

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Research-grade Jatrorrhizine (CAS 3621-38-3) — purity ≥95% HPLC, COA included
A berberine-type alkaloid for inflammation, metabolism and oncology natural-product research — request a quote today

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Weight 1 g

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