KU-55933 KU55933 cas 587871-26-9

KU-55933 is a potent and selective ATP-competitive inhibitor of ATM kinase (IC₅₀ = 13 nM and K_i = 2.2 nM). This small molecule has been shown to sensitize cancer cells to ionizing radiation and chemotherapeutic agents (1). Treating senescent cancer cells (MCF7, A549, and HCT 116) with KU-55933 results in decreased viability and cell death (2). KU-55933 has neuroprotective capabilities by preventing damage caused by oxidative stress