L-Anserine (CAS 584-85-0) Antioxidant Dipeptide | Carnosine Analog, Anti-Glycation, Sports & Healthy-Aging Compound

L-Anserine CAS 584-85-0
N-Methyl-Carnosine Dipeptide & Anti-Glycation Antioxidant

Name: L-Anserine
Brand: Nutrabiotech Chem
SKU: ANSE-58485
Price: Inquiry USD
Availability: InStock

L-Anserine (CAS 584-85-0), beta-alanyl-3-methyl-L-histidine, is a naturally occurring dipeptide concentrated in fish and meat and abundant in human skeletal muscle. More stable than carnosine against serum carnosinase, it acts as a hydrophilic antioxidant and carbonyl-scavenger that protects proteins and lipids from glycation, lipoxidation and advanced glycation end-product (AGE) formation. Molecular formula C10H16N4O3, MW 240.26. Research-grade with COA.

Antioxidant Dipeptide Anti-Glycation (AGE) Carnosine Analog Carnosinase-Resistant Muscle & Exercise Healthy Aging Carbonyl Scavenger

Request a Quote Technical Specs

240.26

MW (C10H16N4O3)

≥97%

Purity (HPLC)

C10H16N4O3

Methylated Carnosine

Molecular Information

Name: L-Anserine
CAS: 584-85-0
Formula: C10H16N4O3
MW: 240.26 g/mol
Class: beta-Alanyl-3-methyl-L-histidine
Core: Methylated histidine dipeptide
Source: Fish / mammalian muscle
MP: 231-268 C (dec.)
Appearance: White to off-white powder
Synonyms: Anserine / Anserin
Storage: 2-8 C

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CAS Number

584-85-0

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Molecular Weight

240.26

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Primary Activity

Antioxidant Dipeptide

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Purity

≥97%

Product Technical Specifications

Complete physicochemical properties and QC parameters for L-Anserine (CAS 584-85-0)

📋 Physicochemical Properties

Product NameL-Anserine (Anserine)
IUPAC Corebeta-Alanyl-3-methyl-L-histidine
CAS Number584-85-0
SynonymsAnserine; Anserin; N-beta-alanyl-3-methylhistidine
Molecular FormulaC10H16N4O3
Molecular Weight240.26 g/mol
SourceFish & mammalian skeletal muscle
AppearanceWhite to off-white powder
Melting Point231-268 C (decomposition)
Water SolubilitySlightly soluble
Organic SolubilityMethanol (heated)
Compound ClassCarnosine analog / methylated dipeptide
HS Code2933.29

🔬 Quality Control & Handling

Purity (HPLC)≥97%
FormNeat solid / powder
Primary TargetReactive carbonyls / glycation & oxidation machinery
Assay ReadoutAGE inhibition; ROS / lipid-peroxidation reduction
MicrobiologyLow bioburden, suitable for cell studies
Storage Condition2-8 C, sealed, protect from light
Solution StabilityPrepare fresh in water / mild acid; avoid prolonged ambient storage
ShippingRoom temperature or cool pack
QC DocumentationCOA / HPLC / NMR / MS / MSDS
Pack Sizes1g / 5g / 10g / 100g / 1KG
Stock StatusIn Stock
Use StatementResearch use only; not for human/clinical use

Key Molecular Targets & Pathway Nodes

Anserine is a direct chemical antioxidant rather than a receptor ligand; its biological reach spans metabolic, muscular and aging-relevant nodes where carbonyl stress and glycation drive dysfunction.

🧬 Advanced Glycation End Products (AGEs) 🔥 Methylglyoxal & Reactive Carbonyls 🛡️ Lipid Peroxidation (MDA / 4-HNE) ⚡ Reactive Oxygen Species (ROS) 💪 Skeletal Muscle & Myofibrils 🏃 Exercise & Recovery Metabolism 🧓 Aging & Proteostasis 🩸 Glucose / Insulin Axis 🧠 Neuronal Carbonyl Stress 🔬 Carnosine / Carnosinase System 🍖 Fish & Meat Bioactives ⚖️ Redox Homeostasis

How L-Anserine Works: Carbonyl Trapping and Redox Buffering

Anserine protects proteins and membranes by acting as a sacrificial nucleophile and metal-chelating antioxidant

Methylated, Carnosinase-Resistant Scavenger

Anserine is the N-methyl derivative of carnosine. The 3-methyl group on the imidazole ring makes it a poor substrate for serum carnosinase, so unlike carnosine it persists in circulation and tissues. This gives anserine a longer functional half-life as an endogenous antioxidant in muscle and brain.

Carbonyl Trapping & Anti-Glycation

The imidazole nitrogen acts as a nucleophile that traps reactive carbonyl species such as methylglyoxal and glyoxal before they cross-link with proteins to form advanced glycation end-products (AGEs). By intercepting these dicarbonyls, anserine slows Maillard-type protein damage implicated in aging, diabetes and muscle degeneration.

Redox Cycling & Metal Chelation

Anserine buffers ROS and RNS, protects membranes from lipid peroxidation (lowering MDA and 4-HNE), and chelates redox-active transition metals such as copper and iron, suppressing Fenton-type hydroxyl radical formation. The net effect is preservation of protein structure, enzyme activity and cellular redox balance under metabolic and exercise stress.

⚖️ Anserine vs Carnosine vs Balenine

Carnosinebeta-Ala-L-His; carnosinase-labile; shorter systemic half-life
Anserine (this product)beta-Ala-3-Me-His; carnosinase-resistant; enriched in human muscle
Balenine / Ophidinebeta-Ala-1-Me-His; the 1-methyl isomer found in some meats
EnzymeSerum carnosinase (CN1/CN2) degrades carnosine, spares anserine
Tissue EnrichmentAnserine > carnosine in human and fish skeletal muscle
Research UseAnti-glycation and antioxidant comparator in aging & metabolic models

♻️ Downstream Biological Consequences

Protein DamageReduced AGE / cross-link formation
Lipid PeroxidationLower MDA and 4-HNE formation
Muscle FunctionPreserved contractile protein integrity under exercise
Redox StateImproved GSH:GSSG balance in stressed cells
Aging PhenotypeAttenuated proteostasis decline in models
Metabolic HealthModest support of glucose handling in studies

Research Applications & Models

Anserine bridges nutritional biochemistry, sports physiology and geroscience — a natural dipeptide studied wherever carbonyl stress and oxidative damage accelerate tissue decline.

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Sports & Exercise Physiology

Studied for its role in high-acid, high-demand skeletal muscle, where anserine buffers metabolic stress, supports calcium handling and may delay fatigue. Frequently paired with carnosine in muscle-composition and endurance research.

Muscle & Recovery

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Healthy Aging & Proteostasis

Investigated as an endogenous anti-glycation defense that attenuates AGE accumulation in long-lived proteins (collagen, lens crystallins), relevant to skin, vascular and connective-tissue aging models.

Anti-Glycation

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Metabolic & Diabetic Research

Used to model dicarbonyl (methylglyoxal) detoxification pathways relevant to diabetes and complications; anserine supplementation studies probe AGE-mediated vascular and renal stress.

AGE / Dicarbonyl

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Neuroprotection

Explored for neuronal carbonyl-stress protection and metal-chelation benefits in models of oxidative injury and proteinopathy, where anserine's brain-relevant antioxidant profile is advantageous.

Redox / Chelation

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Food & Marine Bioactives

A key determinant of fish meat quality and a biomarker of species/freshness; studied in aquaculture and food-science contexts for oxidative stability and shelf-life.

Marine Bioactive

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Antioxidant Assay Standards

Employed as a positive comparator in ORAC, FRAP and carbonyl-trapping assays, and alongside carnosine/balenine to dissect imidazole-dipeptide structure-activity relationships.

Assay Reference

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Cosmeceutical Research

Formulation ingredient studied for anti-AGE and anti-photoaging topical activity, leveraging its carbonyl-scavenging and metal-chelating chemistry.

Anti-Aging Skin

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Cellular Redox Models

Used in cell-based studies of oxidative injury, doxorubicin cardiotoxicity and ischemia-reperfusion, where anserine reduces lipid peroxidation and preserves viability.

Redox Stress

Key Literature & Landmark Publications

Foundational work on imidazole dipeptides, glycation chemistry and muscle function.

Boldyrev AA, et al. Why do we need carnosine, anserine and balenine in our tissues? Physiology & Pathology of the Heart and Skeletal Muscles. 2016. (imidazole dipeptide biology)

Landmark reference

Hipkiss AR. Carnosine and its constituents as therapeutic agents. Curr Protein Pept Sci. 2009;10(6):510-7.

doi: 10.2174/138920309789351051

Aldini G, et al. Cardioprotection by hydrostatic pressure and methylglyoxal scavenging: the role of carnosine and anserine. (imidazole peptides as carbonyl traps).

Landmark reference

Park YJ, et al. Carnosine, anserine and balenine: imidazole dipeptides in energy metabolism and antioxidant defense. (review of muscle dipeptides).

Landmark reference

Kohen R, et al. Skin low molecular weight antioxidants and their role in aging. (anserine as endogenous antioxidant).

Landmark reference

Available Sizes & Ordering

Research-grade L-Anserine / Anserine (CAS 584-85-0) with full QC documentation; standard packs and bulk custom quantities supported.

Tier	Pack Size	Stock Status	Suitable For	Lead Time
Standard	1g	In Stock	Antioxidant & anti-glycation cell assays	Same/next-day ship
Medium	5g	In Stock	Muscle, metabolic and aging models	Same/next-day ship
Large	10g	In Stock	Long-term in vivo & formulation studies	Same/next-day ship
Bulk	100g	In Stock	Food-science, cosmetic and process R&D	Quote to confirm
Industrial	1KG	Made to order	Pilot/production scale, CMO supply	Batch delivery

💡 Reference sizes shown above; for exact pricing and availability please contact us for a quote. Bulk orders qualify for tiered discounts.

Frequently Asked Questions (FAQ)

What is L-Anserine and how does it differ from carnosine?

L-Anserine (CAS 584-85-0) is beta-alanyl-3-methyl-L-histidine, the naturally occurring methylated analog of carnosine (beta-alanyl-L-histidine). Both are imidazole dipeptides concentrated in skeletal muscle, but anserine carries a methyl group on the imidazole ring that makes it a poor substrate for serum carnosinase. As a result anserine persists far longer in circulation and tissues than carnosine, giving it a more durable antioxidant and anti-glycation presence. Formula C10H16N4O3, MW 240.26.

What does anserine actually do at the molecular level?

Anserine is a direct chemical antioxidant rather than a receptor drug. Its imidazole nitrogen traps reactive carbonyl species such as methylglyoxal and glyoxal before they cross-link proteins into advanced glycation end-products (AGEs), and it chelates redox-active metals (Cu, Fe) while buffering ROS/RNS and limiting lipid peroxidation. The net action is protection of proteins, membranes and enzymes from carbonyl and oxidative damage.

Why is anserine interesting for aging and healthy-aging research?

Glycation and carbonyl stress accumulate in long-lived proteins (collagen, lens crystallins, vascular matrix) and are hallmarks of aging and diabetic complications. Because anserine is a potent, tissue-stable AGE inhibitor and carbonyl scavenger, it is used to model endogenous anti-glycation defense and to probe whether boosting imidazole-dipeptide levels attenuates age-related protein damage, stiffness and loss of proteostasis.

Is anserine the same as balenine (ophidine)?

No. Balenine (also called ophidine) is beta-alanyl-1-methyl-L-histidine — the 1-methyl isomer — whereas anserine is the 3-methyl isomer. Both are methylated carnosine analogs and both resist carnosinase, but they are distinct molecules found in different relative amounts across species and meats. Anserine dominates in human and fish muscle; balenine is more prominent in some other meats.

Is anserine soluble and how should it be prepared for lab use?

Anserine is only slightly water-soluble and more soluble in heated methanol. For cell work, prepare fresh stocks in water or mild aqueous acid (e.g., dilute HCl) and avoid prolonged storage at ambient temperature; protect from light and store the solid at 2-8 C. Because the molecule is labile to long ambient exposure, aliquot and use promptly.

Does anserine have a role in sports-nutrition science?

Yes. Anserine, together with carnosine, is highly enriched in fast-twitch skeletal muscle and is studied for buffering metabolic stress, supporting calcium handling and possibly delaying fatigue during high-intensity exercise. Most human research uses combined carnosine/anserine status (often measured as 'anserine+carnosine' in muscle biopsies) as a proxy for muscle antioxidant and acid-buffering capacity.

Is QC documentation provided?

Every batch ships with a Certificate of Analysis (COA) including HPLC purity, NMR structural confirmation and MS data. MSDS/SDS, residual-solvent data and Certificates of Origin are available on request. Sample evaluation is available for qualified institutions — please contact us for details.

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Research-grade L-Anserine (CAS 584-85-0) — purity ≥97% HPLC, COA included
A carnosinase-resistant, anti-glycation antioxidant dipeptide for muscle, aging and metabolic research — request a quote today

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