ISRIB-A17 Custom Synthesis
ISRIB-A17 ISRIB-A17, which is nearly 10-fold more potent than ISRIB-A1 Technical Data for ISRIB M. Wt 451.34 Formula C22H24Cl2N2O4 Storage Store at +4°C Purity ≥99%
M. Wt | 560.61 |
Formula | C30H30F2N6O3 |
Storage | Store at +4°C |
Purity | ≥99% (HPLC) |
CAS Number | 2296729-00-3 |
Other name | AGM-510,AMG-510 racemate,2252403-56-6,AMG510,AMG 510 |
Synoym | AMG-510 racemate,2252403-56-6,4-((S)-4-acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one |
Smiles | O=C(C=C)N1C[C@H](C)N(C2=NC(N(C3=C(C)C=CN=C3C(C)C)C4=C2C=C(F)C(C5=C(O)C=CC=C5F)=N4)=O)CC1. |
Sotorasib, also known as AMG-510, is an acrylamide derived KRAS inhibitor developed by Amgen. It is indicated in the treatment of adult patients with KRAS G12C mutant non small cell lung cancer. This mutation makes up >50% of all KRAS mutations.
Under the new approval On May 28, 2021, sotorasib (Lumakras, Amgen)) can be used to treat Adults with non-small cell lung cancer (NSCLC) that has spread nearby (locally advanced) or to distant locations (metastatic) in the body.
In the clinical trial, called CodeBreaK100, sotorasib achieved a 37.1% objective response rate and a median overall survival of 12.5 months
ISRIB-A17 ISRIB-A17, which is nearly 10-fold more potent than ISRIB-A1 Technical Data for ISRIB M. Wt 451.34 Formula C22H24Cl2N2O4 Storage Store at +4°C Purity ≥99%
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