Sotorasib for lung cancer

Technical Data for sotorasib

M. Wt560.61
FormulaC30H30F2N6O3
StorageStore at +4°C
Purity≥99% (HPLC)
CAS Number2296729-00-3
Other nameAGM-510,AMG-510 racemate,2252403-56-6,AMG510,AMG 510
SynoymAMG-510 racemate,2252403-56-6,4-((S)-4-acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one
Smiles

O=C(C=C)N1C[C@H](C)N(C2=NC(N(C3=C(C)C=CN=C3C(C)C)C4=C2C=C(F)C(C5=C(O)C=CC=C5F)=N4)=O)CC1.

 

  • What is sotorasib made from?

Sotorasib, also known as AMG-510, is an acrylamide derived KRAS inhibitor developed by Amgen. It is indicated in the treatment of adult patients with KRAS G12C mutant non small cell lung cancer. This mutation makes up >50% of all KRAS mutations.

  • What is sotorasib used for?

Under the new approval On May 28, 2021, sotorasib (Lumakras, Amgen)) can be used to treat Adults with non-small cell lung cancer (NSCLC) that has spread nearby (locally advanced) or to distant locations (metastatic) in the body.

  • How effective is sotorasib?

In the clinical trial, called CodeBreaK100, sotorasib achieved a 37.1% objective response rate and a median overall survival of 12.5 months

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