Sotorasib for lung cancer

Technical Data for sotorasib

M. Wt560.61
StorageStore at +4°C
Purity≥99% (HPLC)
CAS Number2296729-00-3
Other nameAGM-510,AMG-510 racemate,2252403-56-6,AMG510,AMG 510
SynoymAMG-510 racemate,2252403-56-6,4-((S)-4-acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one



  • What is sotorasib made from?

Sotorasib, also known as AMG-510, is an acrylamide derived KRAS inhibitor developed by Amgen. It is indicated in the treatment of adult patients with KRAS G12C mutant non small cell lung cancer. This mutation makes up >50% of all KRAS mutations.

  • What is sotorasib used for?

Under the new approval On May 28, 2021, sotorasib (Lumakras, Amgen)) can be used to treat Adults with non-small cell lung cancer (NSCLC) that has spread nearby (locally advanced) or to distant locations (metastatic) in the body.

  • How effective is sotorasib?

In the clinical trial, called CodeBreaK100, sotorasib achieved a 37.1% objective response rate and a median overall survival of 12.5 months


More Posts

ISRIB-A17 Custom Synthesis

ISRIB-A17 ISRIB-A17, which is nearly 10-fold more potent than ISRIB-A1 Technical Data for ISRIB M. Wt 451.34 Formula C22H24Cl2N2O4 Storage Store at +4°C Purity ≥99%

Male Pattern Hair Loss KX-826

What does KX-826 to do with Hairloss ? KX-826 is an androgen receptor (AR) antagonist and a potential first-in-class topical drug for the treatment of

bimatoprost for eyelash growth?

Bimatoprost for eyelash growth Bimatoprost is a prostaglandin analog/prodrug used topically (as eye drops) to control the progression of glaucoma and in the management of

Spermidine & anti-aging research

Spermidine VS Anti-Aging Spermidine is an aliphatic polyamine. Spermidine synthase (SPDS) catalyzes its formation from putrescine. Technical Data for Spermidine M. Wt 145.24600 Formula C7H19N3 Storage

Send Us A Message