Fasoracetam mGluR GABA-B modulator ADHD cognitive research powder sample CAS 110958-19-5

Fasoracetam CAS 110958-19-5 99% High-Purity Racetam Powder mGluR GABA-B Acetylcholine Modulator Nootropic Cognitive Enhancer Anti-Anxiety ADHD Support Research Reagent

Fasoracetam (CAS 110958-19-5) is a novel multi-target racetam nootropic compound. It acts as a positive modulator of metabotropic glutamate receptors, elevates GABA-B receptor expression, and facilitates central cholinergic transmission to regulate neuronal excitability and synaptic plasticity. It ameliorates attention deficit and cognitive impairment caused by neurotransmitter imbalance, relieves neurogenic anxiety, and stabilizes cortical neural activity, serving as a core tool compound for ADHD mechanism research, cognitive pharmacology and mood regulation preclinical studies.

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Fasoracetam (CAS 110958-19-5) NS-105 NFC-1 | Racetam Nootropic, mGluR Modulator & GABA-B Receptor Upregulator, ADHD Research Compound

Fasoracetam CAS 110958-19-5
Racetam Nootropic (NS-105 / NFC-1) — mGluR Modulator & GABA-B Upregulator for ADHD Research

Fasoracetam (CAS 110958-19-5; NS-105; NFC-1; LAM-105) is a synthetic chiral racetam-family nootropic that modulates metabotropic glutamate receptors (mGluR II/III), upregulates GABA-B receptors after chronic dosing, and stimulates neuronal cholinergic signaling. Investigated in Phase II/III trials for ADHD in adolescents with mGluR-network gene mutations. Molecular formula C10H16N2O2, MW 196.25. Research-grade with COA.

Racetam mGluR GABA-B Nootropic NS-105 NFC-1 ADHD Cognition
Request a Quote Technical Specs
196.25
MW (C10H16N2O2)
mGluR II/III
Modulator
Phase II/III
ADHD, mGluR-mutant

Molecular Information

Name: Fasoracetam
CAS: 110958-19-5
Formula: C10H16N2O2
MW: 196.25 g/mol
Class: Racetam / Pyrrolidinone derivative
Core: (5R)-5-(piperidine-1-carbonyl)pyrrolidin-2-one
Targets: mGluR II/III; GABA-B; AChR
Activity: mGluR modulator / GABA-B upregulator
Stereo: Single (R)-enantiomer; 1 stereocenter
Appearance: White to off-white crystalline powder
Cmax: ~3.06 ug/mL (100 mg oral, fed)
Synonyms: NS-105 / NFC-1 / LAM-105
Storage: 0-4 C short / -20 C long
🧪
CAS Number
110958-19-5
⚖️
Molecular Weight
196.25
🎯
Primary Activity
mGluR / GABA-B
✅
Purity
≥98%

Product Technical Specifications

Complete physicochemical properties and QC parameters for Fasoracetam (CAS 110958-19-5)

📋 Physicochemical Properties

  • Product NameFasoracetam
  • IUPAC Core(5R)-5-(piperidine-1-carbonyl)pyrrolidin-2-one
  • CAS Number110958-19-5
  • SynonymsNS-105; NFC-1; LAM-105; 5-oxo-D-prolinepiperidinamide
  • Molecular FormulaC10H16N2O2
  • Molecular Weight196.25 g/mol
  • Exact Mass196.1212
  • SourceSynthetic racetam; single (R)-enantiomer
  • AppearanceWhite to off-white crystalline powder
  • SMILESO=C(N1CCCCC1)[C@@H]2NC(=O)CC2
  • InChIKeyGOWRRBABHQUJMX-MRVPVSSYSA-N
  • Defined Stereocenter1 (R)
  • Compound ClassRacetam / Pyrrolidinone derivative
  • HS Code2934.99

🔬 Quality Control & Handling

  • Purity (HPLC)≥98%
  • FormCrystalline powder
  • Primary TargetmGluR II/III (modulator); GABA-B receptor (upregulator)
  • Other TargetsNeuronal acetylcholine receptors (stimulant)
  • SelectivityNo effects on monoamines (DA, 5-HT, NE)
  • Pathway ReadoutAdenylate-cyclase modulation via mGluR; GABA-B receptor density
  • SolubilityWater, physiological saline, DMSO, polar organic solvents
  • Storage Condition0-4 C short term; -20 C long term; sealed, dry & dark
  • Solution StabilityAliquot to avoid freeze-thaw; protect from humidity
  • ShippingRoom temperature (stable in transit)
  • QC DocumentationCOA / HPLC / NMR / MS / MSDS
  • Pack Sizes10G / 100G / 1KG / 10KG / 25KG / 1Ton
  • Stock StatusIn Stock
  • Use StatementResearch use only; not for human/clinical use

Key Molecular Targets & Pathway Nodes

Fasoracetam cross-regulates three major neurotransmitter systems simultaneously, distinguishing it from classical single-target racetams.

🧬 mGluR1 (modulator) 🔄 mGluR2/3 (modulator) 🧩 mGluR4/8 (modulator) 🔗 GABA-B Receptor (upregulator) 🧠 Cortical/hippocampal membranes ⚡ Adenylate Cyclase (via mGluR) 🎯 Neuronal ACh Receptors (stimulant) 📈 Cortical ACh Tone 🚫 Baclofen-Induced Disruption (reversed) 🛡️ Learned Helplessness Model 🧭 Glutamatergic Balance 🔍 No monoamine effects

How Fasoracetam Works: Multi-Target Modulation of Glutamate, GABA & Acetylcholine

Fasoracetam coordinates metabotropic glutamate, GABA-B and cholinergic signaling without affecting monoamines — supporting cognition, attention and mood regulation.

1

Glutamatergic Modulation via mGluR II/III

In primary neuronal cultures, fasoracetam modulates group II/III metabotropic glutamate receptors (mGluR1, mGluR2/3, mGluR4/8). By tuning mGluR-coupled adenylate cyclase activity, it is proposed to restore glutamatergic balance under states of neurotransmitter hyperexcitotoxicity — a key rationale for its study in ADHD with mGluR-network mutations.

2

GABA-B Receptor Upregulation

After repeated dosing in rats, fasoracetam increases the density and functional sensitivity of cortical/hippocampal GABA-B receptors. This upregulation reverses the memory disruption produced by baclofen (a GABA-B agonist) and underlies the long-term anxiolytic, attention-enhancing and antidepressant effects observed with chronic treatment.

3

Cholinergic & Behavioral Integration

Fasoracetam also stimulates neuronal acetylcholine receptors, increasing cortical ACh tone that supports attention and cognition. The integrated mGluR/GABA-B/AChR action — without affecting dopamine, serotonin or noradrenaline — produces clean cognitive enhancement and rescue of learned helplessness, translating to Phase Ib/II/III ADHD trials in mGluR-mutation-positive adolescents.

⚖️ Fasoracetam vs Piracetam vs Coluracetam

  • Fasoracetam (this product)mGluR II/III modulator; GABA-B upregulator; ADHD trials
  • PiracetamClassical racetam; membrane fluidity / AMPA
  • ColuracetamCHT1 / HACU enhancer; cholinergic
  • Shared CoreAll share the pyrrolidinone ring system
  • Key DistinctionFasoracetam uniquely targets mGluR & GABA-B, not AChE/CHT1
  • Monoamine ProfileNo stimulant/sedative — does not affect DA/5-HT/NE

♻️ Downstream Biological Consequences

  • Glutamate SystemmGluR-coupled adenylate cyclase modulation
  • GABA System↑ GABA-B receptor density & sensitivity
  • Cholinergic↑ Cortical ACh tone (AChR stimulation)
  • BehavioralReversal of baclofen-induced disruption
  • MoodAntidepressant in chronic dosing & learned helplessness
  • AttentionImproved cognition & attention; ADHD Phase II/III

Research Applications & Models

From mGluR-mutant ADHD clinical trials to GABA-B receptor pharmacology and racetam SAR profiling, fasoracetam spans translational and basic neuroscience research.

🧒

ADHD in mGluR-Mutant Adolescents

Investigated in Phase Ib/II/III trials (NFC-1) for ADHD in adolescents with mGluR-network gene mutations — a genotype-stratified psychiatry paradigm.

mGluR / ADHD
🧠

GABA-B Receptor Pharmacology

Reference tool for tracking GABA-B receptor upregulation on cortical/hippocampal membranes after chronic dosing; reverses baclofen-induced memory disruption.

GABA-B / density
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mGluR II/III Modulation

Probe for group II/III metabotropic glutamate receptor signaling via adenylate cyclase in primary neuronal culture; benchmarks for glutamatergic balance.

mGluR II/III
😔

Depression & Learned Helplessness

Potent antidepressant activity in rodent learned-helplessness models, with effects emerging after chronic dosing consistent with GABA-B upregulation.

Antidepressant
📚

Memory Disruption Reversal

Used in rodent memory-disruption assays (e.g. baclofen challenge) to model cognition rescue via GABA-B tone normalization.

Memory rescue
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Racetam SAR Profiling

Key structural comparator alongside piracetam/aniracetam/coluracetam to analyze how 5-position piperidine-amide substitution shifts target profiles.

Racetam SAR

Key Literature & Landmark Publications

The pharmacology and clinical validation of fasoracetam (NS-105 / NFC-1) as a multi-target racetam nootropic.

Nakamura K, Tanaka T. Effect of a novel cognition enhancer NS-105 on learned helplessness in rats: possible involvement of GABA(B) receptor up-regulation after repeated treatment. Eur J Pharmacol. 2000;402(1-2):53-61.
doi: 10.1016/S0014-2999(00)00524-1
Tanaka T, et al. Involvement of cholinergic and GABAergic systems in the reversal of memory disruption by NS-105, a cognition enhancer. Pharmacol Biochem Behav. 1997;56(1):99-106.
doi: 10.1016/S0091-3057(96)00311-1
Ogasawara T, et al. A novel cognition enhancer NS-105 modulates adenylate cyclase activity through metabotropic glutamate receptors in primary neuronal culture. Brain Res. 1999;821(1):79-85.
doi: 10.1016/S0006-8993(99)01128-3
Grebb JA, et al. Phase I single-dose pharmacokinetic and safety study of fasoracetam (NFC-1) in healthy adults. Clin Pharmacol Drug Dev. 2016;5(S1):poster.
NCT02777931 reference
Finding R, et al. Phase Ib dose-escalation trial of fasoracetam (NFC-1) in mGluR network mutation-positive adolescents with ADHD. presented AACAP 2016.
AACAP 2016 / NCT02777931

Available Sizes & Ordering

Research-grade Fasoracetam (CAS 110958-19-5) with full QC documentation; standard packs and bulk custom quantities supported.

TierPack SizeStock StatusSuitable ForLead Time
Standard10GIn StockmGluR / GABA-B binding & cell assaysSame/next-day ship
Medium100GIn StockBehavioral & chronic-dosing studiesSame/next-day ship
Large1KGIn StockLong-term in vivo & formulation workSame/next-day ship
Bulk10KGMade to orderPilot / process scale, CMO supplyQuote to confirm
Industrial25KGMade to orderProduction-scale supplyBatch delivery
Industrial1TonMade to orderProduction-scale synthesisBatch delivery

💡 Reference sizes shown above; for exact pricing and availability please contact us for a quote. Bulk orders qualify for tiered discounts.

Frequently Asked Questions (FAQ)

What is fasoracetam and what does it do?
Fasoracetam (CAS 110958-19-5; NS-105; NFC-1; LAM-105) is a synthetic chiral racetam-family nootropic. In vitro it modulates metabotropic glutamate receptors (mGluR II/III), in rats it upregulates GABA-B receptors after repeat dosing (reversing baclofen-induced memory disruption), and it also stimulates neuronal acetylcholine receptors. It has been investigated in Phase II/III trials for ADHD in adolescents with mGluR-network gene mutations. Formula C10H16N2O2, MW 196.25.
How is fasoracetam different from piracetam and other racetams?
Piracetam and most classical racetams are believed to work via AMPA-receptor modulation and membrane fluidity. Fasoracetam is structurally unique because of its piperidine-1-carbonyl modification at the 5-position of the pyrrolidone ring, which shifts its biological target footprint toward mGluR II/III modulation, GABA-B receptor upregulation, and cholinergic signaling. This multi-target profile supports ADHD research rather than the classical racetam cognition-enhancement paradigm.
What is the mechanism of fasoracetam's antidepressant and cognitive effects?
Fasoracetam acts at three convergent targets. (1) It modulates metabotropic glutamate receptors (mGluR1, mGluR2/3, mGluR4/8) to restore glutamatergic balance. (2) With repeat dosing it upregulates the density and functional sensitivity of GABA-B receptors in cortical/hippocampal membranes, reversing baclofen-induced (GABA-B agonist) memory disruption and producing long-term anxiolytic and antidepressant effects. (3) It stimulates neuronal acetylcholine receptors, increasing cortical ACh tone. Together, these mechanisms improve attention and cognition without affecting monoamines (no dopamine, serotonin, noradrenaline effects).
What are the key experimental readouts for fasoracetam?
Canonical readouts include mGluR binding and adenylate cyclase activity modulation in primary neuronal cultures, GABA-B receptor density and functional sensitivity assays (radioligand binding on cortical membranes after repeat dosing), reversal of baclofen-induced memory disruption in rodent models, learned-helplessness behavioral rescue, and cortical acetylcholine-release measurements. Clinically, the human PK (Cmax ~3.06 μg/mL at 100 mg oral) and ADHD symptom scales are tracked in Phase Ib/II trials in mGluR-mutation-positive adolescents.
How soluble is fasoracetam and how should it be prepared?
Fasoracetam is readily soluble in water, physiological saline, DMSO, and polar organic solvents. For cell assays typical working concentrations are low micromolar; dilute aqueous or DMSO stock into pre-warmed medium keeping final DMSO ≤0.1% v/v. Store the solid at 0-4 C short term or -20 C long term, in a hermetically sealed container protected from moisture and direct light. Aliquot stocks to avoid repeated freeze-thaw.
Is QC documentation provided? Can I request a sample?
Every batch ships with a Certificate of Analysis (COA) including HPLC purity, NMR structural confirmation and MS data. MSDS/SDS, residual-solvent data and Certificates of Origin are available on request. Sample evaluation is available for qualified institutions — please contact us.

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