r,s-equol 99% powder CAS 94105-90-5 /531-95-3 equol

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Equol ,a metabolite of soybeans, is an important isoflavone in humans,specifically binds to 5α-DHT, has a modest affinity for recombinant estrogen receptor ERβ. Phase 2.

Molecular Weight 242.27
Formula C15H14O3
CAS No. 531-95-3
Storage  powder
 in solvent
Synonyms N/A
Smiles C1C(COC2=C1C=CC(=C2)O)C3=CC=C(C=C3)O

Equol is a metabolite produced from the soy phytoestrogen daidzein by the action of gut microflora. Equol has higher affinity for both ERs (estrogen receptors including ERalpha and ERbeta). Equol exists as the enantiomers R-equol and S-equol. S-equol has a high binding affinity, preferential for ERbeta with a Ki of 16 nM whereas R-equol binds more weakly and with a preference for ERalpha K with a Ki of 50 nM. Equol is superior to all other isoflavones in its antioxidant activity. Equol has antioestrogenic properties.  Equol is a 100-fold more potent than daidzein in stimulating an oestrogenic response. Equol is also more effective than daidzein in competing with 3 H-oestradiol for binding to the ER. Equol stimulates the growth of MCF-7 cells in a concentration-dependent manner. Although equol exhibits oestrogenic activity, exposure of MCF-7 cells to equol simultaneously with oestradiol is effective in reducing pS2 mRNA expression. Equol results in the downregulation of ER mRNA expression.

重量 10 kg



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