What does ISRIB to do with memory enhancement ?

ISRIB (integrated stress response inhibitor) is an experimental drug that reverses the effects of eIF2α phosphorylation with an IC50 of 5 nM.

It resets the ISR in the brain of old mice ,restores normal cognitive function in mice after traumatic brain injury

Technical Data for trans-ISRIB

M. Wt451.34
FormulaC22H24Cl2N2O4
StorageStore at +4°C
Purity≥99% (HPLC)
CAS Number1597403-47-8
Boiling Point719.0±60.0 °C(Predicted)
AppearancePowder Form
SmilesO=C(COC1=CC=C(Cl)C=C1)N[C@@H]2CC[C@@H](NC(COC3=CC=C(Cl)C=C3)=O)CC2

trans-ISRIB is an integrated stress response (ISR) inhibitor; reverses the effects of eIF2α phosphorylation (IC50 = 5 nM) and restores cell translation capacity. Acts downstream of PERK, targeting interactions between eIF2α kinases and elF2B. Blocks ATF4 production without altering the IRE1 or ATF6 responses in vitro. Displays memory enhancement in hippocampus-dependent spatial and fear-associated learning in rodents. trans-ISRIB promotes survival of pluripotent stem cells in culture when used in combination with Chroman-1 (Cat. No. 7163), emricasan, and polyamines, a combination known as CEPT. When used as part of the CEPT cocktail, trans-ISRIB improves survival of differentiated cells following cryopreservation. Brain penetrant.

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