Nutrabiotech 9-methyl-beta-carboline 98% 10G Powder, high purity 9-Me-BC powder, selective MAO-A MAO-B inhibitor, dopaminergic neuroprotective compound, BDNF upregulator for neurodegeneration research

9‑Me‑BC 9‑Methyl‑9H‑beta‑carboline CAS 2521‑07‑5 99% High‑Purity Powder MAO‑A MAO‑B Inhibitor Dopaminergic Nootropic Neuroprotective Research Reagent

High‑purity 99% 9‑Me‑BC crystalline powder CAS 2521‑07‑5, selective MAO inhibitor, dopaminergic activator and nootropic compound for neuroprotection and cognitive‑function research.

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9-ME-BC (CAS 2521-07-5) 9-Methyl-β-Carboline MAO Inhibitor | Neuroprotective β-Carboline

9-ME-BC CAS 2521-07-5
9-Methyl-β-Carboline — Monoamine Oxidase Inhibitor

9-ME-BC (CAS 2521-07-5), or 9-methyl-β-carboline, is a naturally inspired β-carboline alkaloid that inhibits monoamine oxidase (MAO-A/MAO-B), raises monoamine tone (dopamine, serotonin, norepinephrine) and limits formation of the neurotoxic MPP+ metabolite. It is widely studied for neuroprotection, dopaminergic survival and cognitive neuroscience. Formula C12H10N2, MW 182.22. Research-grade with COA.

MAO Inhibitorβ-CarbolineNeuroprotectionDopamineParkinson's ResearchCognitiveAntioxidant9-Me-BC
Request a Quote Technical Specs
182.22
MW (C12H10N2)
≥98%
Purity (HPLC)
MAO-A/B
Monoamine oxidase

Molecular Information

Name: 9-ME-BC (9-Methyl-β-carboline)
CAS: 2521-07-5
Formula: C12H10N2
MW: 182.22 g/mol
Class: β-carboline alkaloid
Core: 9-methylpyrido[3,4-b]indole
Target: Monoamine oxidase (MAO-A / MAO-B)
Activity: MAO inhibition; neuroprotection
MP: Not firmly reported
Appearance: Off-white to beige powder
Synonyms: 9-Me-BC / 9-MBC
Storage: -20°C, protect from light
2521-07-5
🧪
CAS Number
182.22
⚖️
Molecular Weight
MAO-A/MAO-B Inhibitor
🎯
Primary Activity
≥98%
✅
Purity

Product Technical Specifications

Complete physicochemical properties and QC parameters for 9-ME-BC (9-Methyl-β-Carboline) (CAS 2521-07-5)

📋 Physicochemical Properties

  • Product Name9-ME-BC (9-Methyl-β-Carboline)
  • IUPAC Name9-methylpyrido[3,4-b]indole
  • CAS Number2521-07-5
  • Synonyms9-Me-BC; 9-MBC; 9-Methylnorharman
  • Molecular FormulaC12H10N2
  • Molecular Weight182.22 g/mol
  • SourceSynthetic β-carboline
  • AppearanceOff-white to beige powder
  • Water SolubilityLow
  • Organic SolubilityDMSO; ethanol (moderate)
  • Compound Classβ-carboline alkaloid / MAO inhibitor
  • HS Code2933.99

🔬 Quality Control & Handling

  • Purity (HPLC)≥98%
  • FormCrystalline powder
  • Primary TargetMonoamine oxidase (MAO-A, MAO-B)
  • Assay ReadoutMonoamine levels; MPP+ attenuation
  • SelectivityMAO vs MAO-B balanced; β-carboline scaffold
  • Storage Condition-20°C, sealed, protect from light
  • Solution StabilityDMSO stock stable weeks at -20°C
  • ShippingRoom temp / cold chain
  • QC DocumentationCOA / HPLC / NMR / MS / MSDS
  • Pack Sizes100mg / 500mg / 1g / 5g / 10g
  • Stock StatusIn Stock
  • Use StatementResearch use only; not for human/clinical use

Key Molecular Targets & Pathway Nodes

9-ME-BC (9-Methyl-β-Carboline) engages the molecular machinery and pathway nodes that define its research utility.

🧬 MAO-A (monoamine oxidase A) 🧬 MAO-B (monoamine oxidase B) 🧬 Dopamine (DA) 🧬 Serotonin (5-HT) 🧬 Norepinephrine (NE) ⚖️ MPP+ neurotoxic pathway 💧 Oxidative stress 🧣 Dopaminergic neurons 🦴 Neuroprotection 🔬 Monoamine turnover

How 9-ME-BC Works: Protecting Monoamine Signaling

9-ME-BC blocks monoamine oxidase and curbs the cascade that destroys dopaminergic neurons

1

MAO-A / MAO-B Catalytic Inhibition

9-ME-BC is a β-carboline that inhibits monoamine oxidase enzymes, particularly MAO-A, slowing the oxidative deamination of dopamine, serotonin and norepinephrine. This raises synaptic and intracellular monoamine availability.

2

Blockade of Neurotoxic MPP+ Formation

By limiting MAO-B-driven oxidation of MPTP-like substrates, 9-ME-BC reduces formation of the mitochondrial toxin MPP+ (1-methyl-4-phenylpyridinium), a key driver of dopaminergic neuron death in Parkinson's models.

3

Neuroprotection, Survival & Cognitive Tone

Elevated monoamines support dopaminergic neuron survival, neurite outgrowth and synaptic plasticity. The net research phenotype is neuroprotection, improved monoamine tone and resilience to oxidative / excitotoxic stress.

⚖️ 9-ME-BC (9-Methyl-β-Carboline) vs Comparators

  • 9-ME-BC (this product)β-carboline; MAO-A/MAO-B inhibition; neuroprotective
  • Harmane / HarmineRelated β-carbolines; stronger MAO-A, psychoactive
  • Selegiline / RasagilineSelective MAO-B (or MAO-B/A) therapeutics
  • MAO Isoform Focus9-ME-BC balances MAO-A/B with antioxidant edge
  • Research NicheDopamine survival & cognitive neuroscience

♻️ Downstream Biological Consequences

  • MonoaminesDA / 5-HT / NE levels preserved
  • MitochondriaLess MPP+; reduced oxidative damage
  • NeuronsDopaminergic survival & plasticity
  • BehaviorCognitive / motor readouts in models
  • Oxidative StateLower reactive-species burden
  • TransmittersMonoamine turnover rebalanced

Research Applications & Models

9-ME-BC is a foundational tool for monoamine, neuroprotection and dopaminergic research.

🧭

Parkinson's & Dopaminergic Models

Studied for dopaminergic neuron survival and MPP+/MPTP toxicity attenuation in neurodegeneration research.

PD Models
🧬

Monoamine Oxidase (MAO) Studies

Benchmark MAO-A/MAO-B inhibitory potency in enzyme and cell assays.

MAO Assay
🧠

Dopamine & Serotonin Research

Probes monoamine tone, receptor coupling and synaptic plasticity.

Monoamines
🧪

Cognitive & Neuroscience

Used in learning, memory and neuroplasticity paradigms.

Cognition
🦴

Antioxidant / Neuroprotection

Models of oxidative stress, ischemia and excitotoxicity.

Antioxidant
🔬

Alkaloid & Drug Discovery

β-carboline scaffold screening and SAR for CNS agents.

Scaffold

Key Literature & Landmark Publications

Foundational work on β-carbolines, MAO inhibition and neuroprotection.

Mckenna DJ, et al. β-carboline alkaloids: towards monoamine oxidase inhibitory therapeutics. (MAO / β-carboline pharmacology).
Landmark reference
Airaksinen MM, et al. β-carbolines: synthesis, metabolism and MAO inhibition. (alkaloid neurochemistry).
Landmark reference
May T, et al. Neurotoxicity of MPTP and MPP+: role of monoamine oxidase. (MPP+ mechanism).
Landmark reference
9-Methyl-β-carboline investigator reports. Neuroprotection and dopaminergic survival models.
Landmark reference
Rommelspacher H, et al. Harmala alkaloids and monoamine oxidase. (review of β-carbolines).
Landmark reference

Available Sizes & Ordering

Research-grade 9-ME-BC (CAS 2521-07-5) with full QC documentation; standard packs and bulk custom quantities supported.

TierPack SizeStock StatusSuitable ForLead Time
Standard100mgIn StockMAO / neurochemistry assaysSame/next-day ship
Medium500mgIn StockCell & dopamine modelsSame/next-day ship
Large1gIn StockNeuroprotection studiesSame/next-day ship
Bulk5gIn StockScreening & formulationQuote to confirm
Industrial10g+Made to orderProcess developmentBatch delivery

💡 Reference sizes shown above; for exact pricing and availability please contact us for a quote. Bulk orders qualify for tiered discounts.

Frequently Asked Questions (FAQ)

What is 9-ME-BC and what does it do?
9-ME-BC (CAS 2521-07-5), or 9-methyl-β-carboline, is a β-carboline alkaloid that inhibits monoamine oxidase (MAO-A/MAO-B), raising dopamine, serotonin and norepinephrine while limiting formation of the neurotoxic MPP+ metabolite. Formula C12H10N2, MW 182.22.
How is 9-ME-BC used in Parkinson's research?
It is studied for dopaminergic neuron survival and for reducing MPP+/MPTP-driven toxicity, making it a tool to model neuroprotection and monoamine preservation in degeneration paradigms.
Is 9-ME-BC a selective MAO-B inhibitor?
No — unlike selegiline/rasagiline, 9-ME-BC balances MAO-A and MAO-B inhibition within the β-carboline scaffold, and is prized for its combined monoamine and antioxidant profile.
What readouts confirm 9-ME-BC activity?
Typical readouts are monoamine levels (HPLC/EC), MAO enzymatic activity, MPP+ attenuation, and dopaminergic neuron survival / neurite-outgrowth assays.
How soluble is 9-ME-BC and how should it be prepared?
It dissolves in DMSO and moderately in ethanol; poorly in water. Prepare a DMSO stock, dilute into assay medium (final DMSO ≤0.1% v/v), and store stocks at -20°C protected from light.
Is QC documentation provided?
Every batch ships with a Certificate of Analysis (COA) including HPLC purity, NMR structural confirmation and MS data; MSDS/SDS and Certificates of Origin are available on request.

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MAO-A/MAO-B Inhibitor — request a quote today

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