Noopept (GVS-111) CAS 157115-85-0 | Potent Nootropic & Cognitive Enhancer | Nutrabiotech Chem

Noopept (GVS-111) CAS 157115-85-0
Potent Peptide-Derived Nootropic for Cognition & Neuroprotection Research

Name: Noopept (GVS-111)
Brand: Nutrabiotech Chem
SKU: NOOPEPT-157115-85-0
Price: Inquiry USD
Availability: InStock

Noopept (CAS 157115-85-0), also known as GVS-111, is a potent, peptide-derived nootropic — the ethyl ester of N-phenylacetyl-L-prolylglycine. Roughly 1,000× more potent than piracetam by weight, it enhances learning and memory by modulating acetylcholine and glutamate (AMPA) signaling while upregulating BDNF and NGF. Formula C17H22N2O4, MW 318.37. Research grade with COA.

NoopeptGVS-111CAS 157115-85-0NootropicCognitive enhancerMemory & learningAMPA / BDNFNeuroprotectiveRacetam-likePeptide-derivedResearch chemical

Request a Quote Technical Specs

318.37

MW (C17H22N2O4)

GVS-111

Synonym

>=98%

Purity (HPLC)

Molecular Information

Name: Noopept (GVS-111)
CAS: 157115-85-0
Formula: C17H22N2O4
MW: 318.37 g/mol
IUPAC: ethyl (2S)-2-[[(2S)-1-oxo-1-(2-phenylacetyl)pyrrolidin-2-yl]carbonylamino]acetate
SMILES: CCOC(=O)CNC(=O)[C@H]1CCCN1C(=O)Cc1ccccc1
Class: Peptide-derived nootropic (dipeptide analog)
Core: Prolylglycine ethyl ester + phenylacetyl
Target: Cholinergic / glutamatergic / neurotrophic
Activity: Cognition, LTP, neuroprotection
Appearance: White to off-white crystalline powder
Synonyms: GVS-111
Storage: -20°C, dry, protect from light

157115-85-0

🧪

CAS Number

318.37

⚖️

Molecular Weight

Nootropic

🎯

Primary Activity

≥98%

✅

Purity

Product Technical Specifications

Complete physicochemical properties and QC parameters for Noopept (GVS-111, CAS 157115-85-0)

📋 Physicochemical Properties

Product NameNoopept (GVS-111)
IUPAC Nameethyl (2S)-2-[[(2S)-1-oxo-1-(2-phenylacetyl)pyrrolidin-2-yl]carbonylamino]acetate
CAS Number157115-85-0
SynonymsGVS-111; N-Phenylacetyl-L-prolylglycine ethyl ester
Molecular FormulaC17H22N2O4
Molecular Weight318.37 g/mol
SourceSynthetic (small-molecule nootropic)
AppearanceWhite to off-white crystalline powder
Water SolubilityLow to moderate (DMSO/ethanol recommended)
Organic SolubilityDMSO, ethanol, methanol
Compound ClassPeptide-derived nootropic (prolylglycine analog)
HS Code2933.99

🔬 Quality Control & Handling

Purity (HPLC)>=98%
FormPowder (research grade)
Primary TargetCholinergic / glutamatergic / neurotrophic
Assay ReadoutACh release; LTP; BDNF/NGF; cognition models
SelectivityMultimodal cognitive / neuroprotective
Storage Condition-20°C, sealed, dry, protect from light
Solution StabilityDMSO stock stable at -20°C; avoid freeze-thaw
ShippingAmbient or cold chain
QC DocumentationCOA / HPLC / NMR / MS / MSDS
Pack Sizes100G / 1KG / 10KG / 25KG / 1 ton
Stock StatusIn Stock
Use StatementResearch use only; not for human consumption or therapeutic use

Key Molecular Targets & Biology Nodes

Noopept acts through a multimodal cognitive axis — simultaneously engaging cholinergic and glutamatergic transmission, synaptic plasticity (LTP) and endogenous neurotrophic support (BDNF/NGF).

🧠 Acetylcholine (ACh) signaling⚡ AMPA receptors🧬 NMDA receptors🌱 BDNF (brain-derived neurotrophic factor)🌱 NGF (nerve growth factor)🧭 Long-term potentiation (LTP)🛡️ Glutamate homeostasis🔥 Antioxidant / anti-excitotoxic😌 Serotonin / dopamine tone (models)🧫 Hippocampus & cortex

How Noopept Works: A Multimodal Cognitive-Enhancement Profile

Unlike single-target agents, Noopept tunes several interconnected brain signaling systems that together support memory, learning and neuronal resilience.

Cholinergic Modulation

Noopept promotes acetylcholine (ACh) release and signaling in hippocampus and cortex — the same neurotransmitter system central to attention, learning and memory that underpins the racetam family.

Glutamate / AMPA Up-Regulation

A defining feature: Noopept increases the density and sensitivity of AMPA receptors and supports NMDA function, strengthening long-term potentiation (LTP) — the cellular basis of learning and memory formation.

Neurotrophic Support (BDNF / NGF)

Noopept upregulates brain-derived and nerve growth factors (BDNF, NGF), promoting synaptic plasticity, neurogenesis and the survival of existing neurons — effects that outlast the compound's acute presence.

Neuroprotection & Antioxidant

By calming excitotoxic glutamate signaling and reducing oxidative stress, Noopept protects neurons in ischemia, trauma and neurodegenerative models, supporting recovery of cognitive function.

⚖️ Noopept vs Piracetam

Noopept (this product)Dipeptide analog; ~1000x potency; ACh + strong AMPA/BDNF
PiracetamTrue 2-pyrrolidone racetam; gram-scale dosing
PotencyNoopept far more potent by mass
MechanismBoth cholinergic; Noopept adds glutamatergic & neurotrophic
StructureNoopept is NOT a true racetam
Research NicheCognitive enhancement & neuroprotection

♻️ Downstream Biological Consequences

TransmitterACh up; glutamate balanced
ReceptorAMPA density/sensitivity up
PlasticityLTP enhanced
TrophicBDNF / NGF increased
FunctionMemory, learning, focus improved
ResilienceAntioxidant / neuroprotective

Noopept vs Piracetam: How They Compare

A side-by-side view of how Noopept relates to the classic racetam benchmark, piracetam — the comparison most researchers search for.

🧪 Noopept (this product)

Chemical ClassPeptide-derived dipeptide analog
True Racetam?No (racetam-like only)
Relative Potency~1,000× piracetam by weight
Core MechanismACh + AMPA up + BDNF/NGF
Key EdgeAMPA-receptor & neurotrophic drive
Research UseCognition & neuroprotection

🧪 Piracetam (benchmark)

Chemical Class2-Pyrrolidone (true racetam)
True Racetam?Yes
Relative PotencyBaseline (gram-scale dosing)
Core MechanismPrimarily cholinergic / membrane
Key EdgeLong safety history, mild effect
Research UseCognitive reference compound

Research & Application Areas

Noopept is a versatile cognitive-research reagent spanning memory, synaptic plasticity, neurotrophic biology, neuroprotection and behavioral models.

🧠

Memory & Learning

Core tool for studying acquisition, consolidation and recall in cognitive models.

Cognition

⚡

Synaptic Plasticity (LTP)

Probe AMPA-receptor and LTP mechanisms underlying learning.

Plasticity

🌱

Neurotrophic Research

Quantify BDNF/NGF induction and neurogenesis endpoints.

Neurotrophins

🛡️

Neuroprotection

Ischemia, TBI and excitotoxicity models of neuronal resilience.

Protection

😌

Anxiolytic / Mood Models

Anxiolytic-like and monoamine-modulating effects in research.

Behavior

💊

Nootropic Stack Studies

Combination research with choline sources and other cognitive agents.

Stacking

Noopept in Nootropic Research & Combination Studies

Noopept is frequently studied alongside complementary cognitive agents. The combinations below are described at the preclinical / research level — the material supplied here is strictly for laboratory use.

🔗 With Choline Sources

Noopept is often paired with choline donors (e.g., alpha-GPC, citicoline) in cognitive research to support the acetylcholine limb of its mechanism.

Cholinergic support

🔗 With Other Racetams

Studied in combination with piracetam, aniracetam or phenylpiracetam to compare and amplify cognitive signaling pathways.

Racetam family

🌱 With Neurotrophic Agents

Paired with compounds that also raise BDNF/NGF to investigate synaptogenesis and recovery paradigms.

Neurogenesis

🛡 ️ With Antioxidants

Combined with antioxidant agents in neuroprotection and ischemia-reperfusion research.

Antioxidant

Key Literature & Landmark Publications

Representative and landmark work on Noopept mechanism, neurotrophic effects, neuroprotection and cognitive enhancement.

Noopept (GVS-111): development and profile of a potent peptide-derived nootropic with cognition-enhancing activity. Original Russian pharmacology.

Landmark reference

Noopept increases BDNF and NGF expression in the hippocampus and cortex. Neurotrophic study.

Representative study

Noopept up-regulates AMPA receptor density and enhances long-term potentiation (LTP). Synaptic plasticity.

Representative study

Cognitive recovery after traumatic brain injury supported by Noopept in research models. TBI model.

Representative study

Neuroprotective effects of Noopept in cerebral ischemia and excitotoxicity models. Ischemia model.

Representative study

Noopept vs piracetam: comparative potency and mechanism in cognitive assays. Comparison study.

Representative study

Anxiolytic-like and monoaminergic-modulating properties of Noopept in behavioral models. Behavioral study.

Representative study

Available Sizes & Ordering

Research-grade Noopept (CAS 157115-85-0) with full QC documentation; standard packs and bulk custom quantities supported.

Tier	Pack Size	Stock Status	Suitable For	Lead Time
Standard	100G	In Stock	Lab screening / pilot sampling	Same/next-day ship
Medium	1KG	In Stock	Pilot / small-batch production	Same/next-day ship
Large	10KG	In Stock	Production / process development	Same/next-day ship
Bulk	25KG	In Stock	Commercial-scale supply	Quote to confirm
Industrial	1 ton	Made to order	Full-scale manufacturing	Batch delivery

💡 Reference sizes shown above; for exact pricing and availability please contact us for a quote. Bulk orders qualify for tiered discounts.

Frequently Asked Questions (FAQ)

What is Noopept and what is it used for?

Noopept (CAS 157115-85-0), also known as GVS-111, is a potent, peptide-derived nootropic — the ethyl ester of N-phenylacetyl-L-prolylglycine. It is studied as a cognitive enhancer and neuroprotective agent, roughly 1,000x more potent than piracetam by weight. It modulates acetylcholine and glutamate (AMPA) signaling and upregulates BDNF/NGF. Formula C17H22N2O4, MW 318.37. Supplied as research-grade material with COA.

How does Noopept work (mechanism of action)?

Noopept works through several complementary systems: (1) it promotes acetylcholine release and signaling; (2) it increases AMPA receptor density and sensitivity and supports NMDA function, strengthening long-term potentiation (LTP); (3) it upregulates BDNF and NGF, supporting plasticity and neuronal survival; and (4) it exerts antioxidant / anti-excitotoxic neuroprotection. This multimodal profile distinguishes it from single-target agents.

Noopept vs Piracetam — what is the difference?

Piracetam is a true 2-pyrrolidone "racetam" typically studied at gram-scale doses, whereas Noopept is a dipeptide (prolylglycine) analog that is roughly 1,000x more potent by mass. Both affect cholinergic signaling, but Noopept additionally and strongly engages AMPA receptors and neurotrophic factors (BDNF/NGF). Structurally, Noopept is NOT a true racetam despite often being grouped with them.

Is Noopept a racetam?

No. Noopept is chemically a dipeptide derivative (N-phenylacetyl-L-prolylglycine ethyl ester) and lacks the 2-pyrrolidone core that defines the racetam class (piracetam, aniracetam, etc.). It is "racetam-like" in cognitive effect and is frequently discussed alongside racetams, but it is structurally distinct.

How soluble is Noopept and how should it be prepared?

Noopept has low-to-moderate water solubility; dissolve in DMSO (or ethanol/methanol) to prepare a fresh stock, with gentle warming/sonication if needed. It is not suited to plain aqueous vehicles. Store DMSO stocks at -20°C and avoid repeated freeze-thaw. Handling is for research use only.

Does Noopept affect BDNF and NGF (neurotrophic effects)?

Yes — a well-documented property. Noopept upregulates brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in brain regions such as the hippocampus and cortex. These neurotrophic effects support synaptic plasticity, neurogenesis and neuronal survival, and help explain its long-lasting cognitive and protective benefits in research models.

Is Noopept neuroprotective?

Yes. In preclinical research Noopept shows neuroprotective activity: it reduces oxidative stress, dampens excitotoxic glutamate signaling, and improves cognitive outcomes in models of cerebral ischemia, traumatic brain injury and neurodegeneration. These effects make it a useful tool for studying neuronal resilience and recovery.

Can Noopept be combined with choline or other nootropics (stacking)?

In the research literature Noopept is frequently studied in combination with choline donors (e.g., alpha-GPC, citicoline) to support the acetylcholine arm of its mechanism, and with other cognitive agents to compare signaling pathways. These descriptions refer to laboratory/ preclinical research only; the material supplied here is strictly for research use and is not a consumer product.

What is the regulatory / legal status of Noopept?

Noopept is a research chemical supplied strictly for laboratory use; it is not approved as a food, dietary supplement or drug in most jurisdictions and is not for human consumption. (Note: it is a prescription nootropic in some countries, e.g., Russia — included only as regulatory background, not as guidance.) Researchers must comply with local regulations governing chemical handling.

Is QC documentation provided?

Every batch ships with a Certificate of Analysis (COA) including HPLC purity, structural confirmation (NMR) and identity data; MSDS/SDS is included and additional spectra (MS) are available on request.

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Research-grade Noopept (CAS 157115-85-0) — purity >=98% HPLC, COA included
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Weight	1 g

Noopept Omberacetam CAS 157115-85-0 99% Potent Nootropic BDNF NGF Enhancer Neuroprotective Cognitive Enhancement Research Reagent