Nutrabiotech Gastrodin 98% 1G Powder, high purity natural Gastrodin powder, Gastrodia elata bioactive extract, neuroprotective compound, anti-neuroinflammation & cognitive regulation research raw material

Gastrodine CAS 62499-27-8 98% Purity Gastrodia Elata Extract Powder

High purity Gastrodine powder CAS 62499-27-8 with 98% HPLC purity. Natural active compound from Gastrodia Elata, professional neuroprotective research reagent, factory bulk supply, full certificates and fast global delivery.
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Gastrodine (CAS 62499-27-8) Natural Phenolic Glucoside | GABAergic Neuroprotectant (Gastrodia elata)

Gastrodine CAS 62499-27-8
Natural Phenolic Glucoside (GABAergic Neuroprotectant)

Gastrodine (CAS 62499-27-8) is the principal bioactive glucoside of the orchid Gastrodia elata. It crosses the blood-brain barrier, is hydrolyzed to p-hydroxybenzyl alcohol, and exerts GABAergic and glutamatergic modulation with antioxidant and anti-inflammatory effects — widely studied for sleep, anxiety, vertigo and neuroprotection. Formula C13H18O7, MW 286.28. Research-grade with COA.

GastrodineGABANeuroprotectionNatural ProductGastrodia elataSleepVertigoAntioxidant
Request a Quote Technical Specs
286.28
MW (C13H18O7)
≥98%
Purity (HPLC)
GABA
Neuro modulator

Molecular Information

Name: Gastrodine
CAS: 62499-27-8
Formula: C13H18O7
MW: 286.28 g/mol
Class: Phenolic glucoside (natural product)
Core: 4-(hydroxymethyl)phenyl β-D-glucopyranoside
Target: GABAergic / glutamatergic systems
Activity: Neuroprotection; sleep & calm
MP: Not firmly reported
Appearance: White crystalline powder
Synonyms: Gastrodia elata glucoside
Storage: -20°C, protect from light
62499-27-8
🧪
CAS Number
286.28
⚖️
Molecular Weight
GABAergic / Neuroprotective
🎯
Primary Activity
≥98%
✅
Purity

Product Technical Specifications

Complete physicochemical properties and QC parameters for Gastrodine (CAS 62499-27-8)

📋 Physicochemical Properties

  • Product NameGastrodine
  • IUPAC Name(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[4-(hydroxymethyl)phenoxy]oxane-3,4,5-triol
  • CAS Number62499-27-8
  • SynonymsGastrodine; 4-(hydroxymethyl)phenyl β-D-glucopyranoside
  • Molecular FormulaC13H18O7
  • Molecular Weight286.28 g/mol
  • SourceBotanical (Gastrodia elata) / semi-synthetic
  • AppearanceWhite crystalline powder
  • Water SolubilityGood (polar glucoside)
  • Organic SolubilityDMSO; methanol
  • Compound ClassPhenolic glycoside / neuroactive natural product
  • HS Code2938.90

🔬 Quality Control & Handling

  • Purity (HPLC)≥98%
  • FormCrystalline powder
  • Primary TargetGABAergic / glutamatergic modulation
  • Assay ReadoutSleep / neurobehavior; oxidative markers
  • SelectivityNatural-product multi-target neuroactivity
  • Storage Condition-20°C, sealed, protect from light
  • Solution StabilityAqueous/DMSO stock stable at -20°C
  • ShippingRoom temp / cold chain
  • QC DocumentationCOA / HPLC / NMR / MS / MSDS
  • Pack Sizes100mg / 500mg / 1g / 5g / 10g
  • Stock StatusIn Stock
  • Use StatementResearch use only; not for human/clinical use

Key Molecular Targets & Pathway Nodes

Gastrodine engages the molecular machinery and pathway nodes that define its research utility.

🧬 GABAergic system 🧬 Glutamate (NMDA) modulation 🧪 Oxidative stress 🧪 Neuroinflammation 🞧 BBB permeability 🧭 Sleep / anxiety 💧 Excitotoxicity 🦴 Neuroprotection 🔬 Natural-product assays 🧭 Vertigo / cerebellum

How Gastrodine Works: Calming and Protecting the Brain

Gastrodine modulates GABA/glutamate and quenches oxidative stress to protect neurons

1

Brain Penetration & Conversion to p-Hydroxybenzyl Alcohol

Gastrodine crosses the blood-brain barrier and is hydrolyzed to its aglycone p-hydroxybenzyl alcohol, the species thought to mediate much of the activity.

2

GABAergic & Glutamatergic Modulation

It enhances GABAergic inhibitory tone and dampens excessive glutamatergic (NMDA) signaling, producing calming, sleep-promoting and anti-excitotoxic effects.

3

Antioxidant, Anti-Inflammatory & Neuroprotection

Gastrodine reduces reactive-oxygen species and neuroinflammation and protects neurons against ischemia, excitotoxicity and age-related injury.

⚖️ Gastrodine vs Comparators

  • Gastrodine (this product)Natural phenolic glucoside; GABA/glutamate modulator
  • p-Hydroxybenzyl alcoholActive aglycone of gastrodine
  • Synthetic GABA drugsDirect GABA-A/GABA-B agents
  • Selective EdgeMulti-target natural neuroprotectant
  • Research NicheSleep, anxiety, neuroprotection

♻️ Downstream Biological Consequences

  • NeurotransmittersGABA up; glutamate balanced
  • Oxidative stateROS reduced
  • InflammationNeuroinflammation lowered
  • NeuronsIschemia/excitotoxin protected
  • BehaviorSleep & calm readouts
  • ModelsVertigo & cerebellar studies

Research Applications & Models

Gastrodine is a key natural-product tool for neuroscience and neuroprotection.

🦴

Neuroprotection Research

Studied against ischemia, excitotoxicity and oxidative neuronal injury.

Neuroprotect
🧭

Sleep & Anxiolytic Models

Investigated for sedation, sleep architecture and anxiety-like behavior.

Sleep
🧭

Vertigo & Cerebellar Studies

Traditional and experimental use in vestibular / balance disorders.

Vertigo
💧

Ischemia / Reperfusion Models

Probes stroke and hypoxic neuronal injury.

Ischemia
🧬

GABA Pharmacology

Examines inhibitory tone and glutamate balance.

GABA
🔬

Natural-Product Research

Botanical neuroactive screening and standardization.

Natural

Key Literature & Landmark Publications

Landmark work on Gastrodia elata constituents and neuropharmacology.

Investigator reports. Gastrodine neuroprotection and GABA modulation.
Landmark reference
Review. Gastrodia elata and gastrodine pharmacology.
Landmark reference
Preclinical reports. Gastrodine in ischemia and excitotoxicity.
Landmark reference
Studies. Gastrodine sleep, anxiety and vertigo models.
Landmark reference
Metabolism literature. Gastrodine to p-hydroxybenzyl alcohol.
Landmark reference

Available Sizes & Ordering

Research-grade Gastrodine (CAS 62499-27-8) with full QC documentation; standard packs and bulk custom quantities supported.

TierPack SizeStock StatusSuitable ForLead Time
Standard100mgIn StockNeuro / natural-product assaysSame/next-day ship
Medium500mgIn StockCell & receptor studiesSame/next-day ship
Large1gIn StockIn vivo neuro modelsSame/next-day ship
Bulk5gIn StockScreening & formulationQuote to confirm
Industrial10g+Made to orderProcess developmentBatch delivery

💡 Reference sizes shown above; for exact pricing and availability please contact us for a quote. Bulk orders qualify for tiered discounts.

Frequently Asked Questions (FAQ)

What is gastrodine and where does it come from?
Gastrodine (CAS 62499-27-8) is the principal phenolic glucoside of the orchid Gastrodia elata. It is a natural-product neuroactive compound. Formula C13H18O7, MW 286.28.
How does gastrodine affect the brain?
It crosses the BBB, converts to p-hydroxybenzyl alcohol, and modulates GABAergic and glutamatergic signaling while reducing oxidative stress and inflammation — calming and protecting neurons.
What conditions is gastrodine researched for?
Sleep and anxiety, vertigo / vestibular disorders, ischemia and excitotoxic neuronal injury, and general neuroprotection.
What readouts confirm activity?
GABA/glutamate assays, oxidative-stress markers, sleep/behavior tests, and neuronal-viability / infarct models.
How soluble is gastrodine and how should it be prepared?
As a polar glucoside it is water-soluble and also dissolves in DMSO/methanol. Prepare aqueous or DMSO stocks and store at -20°C protected from light.
Is QC documentation provided?
Every batch ships with a Certificate of Analysis (COA) including HPLC purity, NMR structural confirmation and MS data; MSDS/SDS and Certificates of Origin are available on request.

Need Gastrodine for Your Research?

Research-grade Gastrodine (CAS 62499-27-8) — purity ≥98% HPLC, COA included
GABAergic / Neuroprotective — request a quote today

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Weight 1 g

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