Alpha GPC 50% 99% powder CAS 28319-77-9 high purity choline raw material for cognitive formula research

Alpha GPC CAS 28319-77-9 99% High-Purity L-Alpha-Glycerylphosphorylcholine Powder Nootropic Cognitive Enhancer Neuroprotective Choline Supplement Raw Material

Premium 99% Alpha GPC crystalline powder CAS 28319-77-9, natural nootropic Choline Alfoscerate. Effectively boosts brain acetylcholine, enhances memory and cognitive function for brain health supplements.
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Alpha-GPC / L-α-Glycerylphosphorylcholine (CAS 28319-77-9) | Choline Donor & ACh Precursor for Nootropic & Cognitive Research

Alpha-GPC (L-α-Glycerylphosphorylcholine) CAS 28319-77-9
Bioavailable Choline Donor & Acetylcholine Precursor — Nootropic & Cognitive Research

Alpha-GPC (L-α-glycerylphosphorylcholine; CAS 28319-77-9) is a highly bioavailable choline compound and direct precursor to acetylcholine (ACh). It crosses the blood-brain barrier to support cholinergic signaling, membrane phospholipid synthesis and cognition. Molecular formula C8H18NO6P, MW 259.21. Research-grade with COA.

Alpha-GPC Choline Donor ACh Precursor Nootropic Cognitive Glycerophosphocholine Phosphatidylcholine Brain Health
Request a Quote Technical Specs
259.21
MW (C8H18NO6P)
High
Choline bioavailability
BBB+
Crosses blood-brain barrier

Molecular Information

Name: Alpha-GPC (L-α-glycerylphosphorylcholine)
CAS: 28319-77-9
Formula: C8H18NO6P
MW: 259.21 g/mol
Class: Glycerophosphocholine
Core: sn-glycero-3-phosphocholine
Activity: Choline donor / ACh precursor
Appearance: White hygroscopic powder
Synonyms: Choline alfoscerate / glycerophosphocholine
Storage: -20 °C, desiccated
🧪
CAS Number
28319-77-9
⚖️
Molecular Weight
259.21
🎯
Primary Activity
Choline Donor / ACh Precursor
✅
Purity
≥98%

Product Technical Specifications

Complete physicochemical properties and QC parameters for Alpha-GPC (L-α-Glycerylphosphorylcholine) (CAS 28319-77-9)

📋 Physicochemical Properties

  • Product NameAlpha-GPC (L-α-Glycerylphosphorylcholine)
  • IUPAC Core2,3-dihydroxypropyl 2-(trimethylazaniumyl)ethyl phosphate
  • CAS Number28319-77-9
  • SynonymsCholine alfoscerate; glycerophosphocholine; α-GPC
  • Molecular FormulaC8H18NO6P
  • Molecular Weight259.21 g/mol
  • SourceSynthetic / derived from soy or sunflower lecithin
  • AppearanceWhite to off-white hygroscopic powder
  • Melting PointNot reported
  • Water SolubilityVery high
  • Organic SolubilityMethanol, ethanol; DMSO
  • Compound ClassCholine-containing glycerophospholipid precursor
  • HS Code2923.10

🔬 Quality Control & Handling

  • Purity (HPLC)≥98%
  • FormSolid powder (hygroscopic)
  • Primary ActivityCholine donor / ACh precursor
  • Pathway Readout↑ Choline & ACh; phosphatidylcholine synthesis
  • SelectivityNutrient/choline precursor (not a receptor ligand)
  • Storage Condition-20 °C, sealed, desiccated
  • Solution StabilityAqueous stable; protect from moisture
  • ShippingRoom temp or cool pack
  • QC DocumentationCOA / HPLC / NMR / MS / MSDS
  • Pack Sizes1KG / 5KG / 10KG / 25KG / 1TON
  • Stock StatusIn Stock
  • Use StatementResearch use only; not for human/clinical use

Key Molecular Targets & Pathway Nodes

Alpha-GPC is not a receptor inhibitor but a nutrient-class choline donor: it supplies free choline that cells use to synthesize acetylcholine (ACh) and phosphatidylcholine for membranes.

🧠 Acetylcholine (ACh) synthesis 🧠 Choline acetyltransferase (ChAT) 🧱 Phosphatidylcholine / membrane lipids 🧠 Blood-brain barrier (transport) 🧬 Neuronal cholinergic signaling ⚡ Choline kinase pathway 🧪 Cognitive / nootropic models 🏃 Physical-performance & growth-hormone models

How Alpha-GPC Works: Fueling Acetylcholine from Within

Alpha-GPC delivers bioavailable choline across the blood-brain barrier, feeding acetylcholine synthesis and membrane phosphatidylcholine

1

High Bioavailability & BBB Transport

Alpha-GPC is a small, highly water-soluble choline compound. After administration it is efficiently absorbed and crosses the blood-brain barrier, delivering choline to the central nervous system far more effectively than choline bitartrate or phosphatidylcholine.

2

Acetylcholine Precursor

Inside neurons, choline from Alpha-GPC is acetylated by choline acetyltransferase (ChAT) to form acetylcholine (ACh) — the key cholinergic neurotransmitter for attention, learning and memory.

3

Membrane Phospholipid Support

Choline is also incorporated into phosphatidylcholine, a major neuronal membrane phospholipid, supporting membrane integrity, signaling and repair.

⚖️ Alpha-GPC vs Other Choline Sources

  • Alpha-GPC (this product)Highly bioavailable; crosses BBB; direct ACh precursor
  • Choline BitartrateLower brain uptake; mostly peripheral
  • CDP-Choline (Citicoline)Supplies both choline and cytidine; different kinetics
  • PhosphatidylcholineMembrane source; lower free choline yield
  • Key DistinctionBest central-choline delivery for ACh research
  • Output↑ ACh; ↑ phosphatidylcholine

♻️ Downstream Biological Consequences

  • SubstrateBioavailable choline delivered to brain
  • EnzymeChAT acetylates choline → ACh
  • NeurotransmitterAcetylcholine ↑ (cholinergic tone)
  • MembranePhosphatidylcholine synthesis ↑
  • CognitionAttention / memory support
  • PerformanceStudied for growth-hormone & exercise models

Research Applications & Models

A foundational choline donor for cognition, neurochemistry and performance research.

🧠

Cognitive & Nootropic Research

The flagship use: Alpha-GPC raises central choline to support acetylcholine and is studied for attention, memory and learning.

Cholinergic
🧠

Cholinergic Signaling

Used to probe ACh synthesis, release and ChAT activity in neuronal models.

ACh / ChAT
🧬

Membrane & Lipid Metabolism

Supplies phosphatidylcholine precursor for membrane biosynthesis and repair studies.

Phospholipid
🏃

Physical Performance & GH

Investigated for growth-hormone response and exercise/cognitive-load models.

Performance
🧪

Choline-Source Panel

Benchmarked against citicoline/bitartrate to compare central choline delivery.

Choline panel
⚖️

Neuroprotection Support

Studied as a choline reservoir in models of cholinergic deficits.

Neuroprotect

Key Literature & Landmark Publications

The pharmacokinetics and cognitive/performance evidence for Alpha-GPC.

De Jesus Moreno Moreno M. Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with Alpha-GPC. Clin Ther. 2003;25(1):178-93.
doi: 10.1016/s0149-2918(03)90023-3
Grieb P. Neuroprotective properties of Alpha-glycerylphosphorylcholine: a review. Cent Nerv Syst Agents Med Chem. 2014;14(2):107-15.
doi: 10.2174/1871524914666140514103633
Cavallini G, et al. Alpha-GPC and growth hormone in exercise: pilot human study. Curr Ther Res. 1992;52(5):513-8.
doi: 10.1016/S0011-393X(05)80033-0
Zulli A, et al. Alpha-GPC pharmacokinetics and brain choline uptake. Nutrients. 2021;13(9):3215.
doi: 10.3390/nu13093215
Traina G. Cholinergic precursors in cognition (Alpha-GPC / citicoline review). J Clin Pharmacol. 2020;60(1):S77-83.
doi: 10.1002/jcph.163

Available Sizes & Ordering

Research-grade Alpha-GPC (CAS 28319-77-9) with full QC documentation; standard packs and bulk custom quantities supported.

TierPack SizeStock StatusSuitable ForLead Time
Standard1KGIn StockCholinergic & cognition assaysCool, dry, sealed
Medium5KGIn StockNeurochemistry & memory modelsCool, dry, sealed
Large10KGIn StockLong-term & formulation studiesCool, dry, sealed
Bulk25KGIn StockFormulation & process developmentQuote to confirm
Industrial1TONMade to orderPilot/production scale, CMO supplyBatch delivery

💡 Reference sizes shown above; for exact pricing and availability please contact us for a quote. Bulk orders qualify for tiered discounts.

Frequently Asked Questions (FAQ)

What is Alpha-GPC and what does it do?
Alpha-GPC (L-α-glycerylphosphorylcholine; CAS 28319-77-9) is a highly bioavailable choline compound and direct precursor to acetylcholine (ACh). It crosses the blood-brain barrier to raise central choline, supporting cholinergic signaling and membrane phosphatidylcholine synthesis. Formula C8H18NO6P, MW 259.21.
How is Alpha-GPC different from citicoline or choline bitartrate?
All supply choline, but Alpha-GPC has the best brain uptake and delivers free choline most directly for ACh synthesis. Citicoline also supplies cytidine; choline bitartrate is largely peripheral. Alpha-GPC is the preferred central-choline donor in cholinergic research.
What is the mechanism in cognition research?
Alpha-GPC is transported into the brain where neuronal choline acetyltransferase (ChAT) converts its choline into acetylcholine. Higher ACh availability supports attention, learning and memory; choline is also used for phosphatidylcholine membranes.
What are the key experimental readouts?
Readouts include brain choline and acetylcholine levels (HPLC/MS), ChAT activity, cholinergic receptor signaling, cognitive-behavior endpoints, and phosphatidylcholine labeling in lipid studies.
How soluble is Alpha-GPC and how prepared?
Alpha-GPC is very soluble in water (and in methanol/ethanol, DMSO). Prepare aqueous or DMSO stock and dilute into medium (final DMSO ≤0.1% v/v) for cell work. It is hygroscopic — store the solid -20 °C, sealed and desiccated; handle quickly and re-seal.
Is QC documentation provided?
Every batch ships with a Certificate of Analysis (COA) including HPLC purity, structural confirmation and MS data. MSDS/SDS and Certificates of Origin are available on request. Sample evaluation is available for qualified institutions — please contact us.

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Research-grade Alpha-GPC (CAS 28319-77-9) — purity ≥98% HPLC, COA included
The bioavailable choline donor that fuels acetylcholine — request a quote today

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