Bulk Epitalon Powder | Natural Longevity Peptide for Immune & Hormone Balance

Epitalon Epithalon AEDG CAS 307297‑39‑8 High‑Purity Lyophilized Tetrapeptide Powder Telomerase Activator Longevity Anti‑Aging Biochemical Research Reagent

High‑purity freeze‑dried Epitalon (Epithalon, AEDG tetrapeptide) powder CAS 307297‑39‑8 is a synthetic short‑chain bio‑active tetrapeptide consisting of alanine‑glutamic acid‑aspartic acid‑glycine. It acts as an effective telomerase activator to facilitate telomere maintenance and slow down cellular senescence. This pineal‑gland‑derived biopeptide can adjust circadian rhythm, boost antioxidant capacity, sustain chromosomal‑DNA stability and modulate the ageing‑related cell signalling. Widely applied in laboratory research of telomere‑repair, cell‑lifespan extension, anti‑ageing mechanism, pineal‑gland regulation and senescence‑associated‑disease assays. All batches undergo HPLC‑based purity testing, custom‑made packaging and bulk‑powder supply are accessible for global peptide‑science and ageing‑biology research clients. This product is merely used for scientific laboratory‑research.

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Epitalon (CAS 307297-39-8) Telomerase Activator Peptide | AEDG, Anti-Aging, Telomere Elongation

Epitalon CAS 307297-39-8
Telomerase Activator & Geroprotective Peptide

Ala-Glu-Asp-Gly (AEDG) tetrapeptide that upregulates telomerase activity, elongates telomeres, and regulates melatonin/cortisol circadian rhythms. Demonstrated 12.3% lifespan increase in mice, 6-fold leukemia reduction, and geroprotective effects across aging, neuroprotection, and retinal health models. A landmark peptide in longevity and telomere biology research.

Telomerase Activator Telomere Elongation Geroprotector Pineal Gland Peptide Anti-Aging Neuroprotective Circadian Regulator
Request a Quote Technical Specs
390.35
MW (C14H22N4O9)
≥98%
Purity (HPLC)
+12.3%
Lifespan (mice)

Molecular Information

Name: Epitalon
CAS: 307297-39-8
Formula: C14H22N4O9
MW: 390.35 g/mol
Sequence: Ala-Glu-Asp-Gly (AEDG)
Length: Tetrapeptide (4 aa)
Source: Synthetic (SPPS)
Appearance: White to off-white
  lyophilized powder
Synonyms: Epithalon / Epithalone /
  AEDG tetrapeptide
Storage: -20°C, protect from
  light and moisture
🧪
CAS Number
307297-39-8
⚖️
Molecular Weight
390.35
🎯
Primary Activity
Telomerase Activator
✅
Purity
≥98%

Product Technical Specifications

Complete physicochemical properties and QC parameters for Epitalon (CAS 307297-39-8)

📋 Physicochemical Properties

  • Product NameEpitalon
  • SequenceAla-Glu-Asp-Gly (AEDG)
  • CAS Number307297-39-8
  • SynonymsEpithalon; Epithalone; AEDG tetrapeptide
  • Molecular FormulaC14H22N4O9
  • Molecular Weight390.35 g/mol
  • Peptide Length4 amino acids (tetrapeptide)
  • SourceSynthetic (SPPS)
  • Synthesis MethodSolid-phase peptide synthesis (SPPS)
  • OriginPineal gland peptide (Khavinson)
  • PubChem CIDPending assignment

🔬 Quality Control & Handling

  • Purity (HPLC)≥98%
  • AppearanceWhite to off-white lyophilized powder
  • SolubilityDMSO (250 mg/mL); Water
  • Storage Condition-20°C, protect from light & moisture
  • FormLyophilized powder
  • ReconstitutionReconstitute in sterile water or DMSO
  • HandlingUse aseptic technique; avoid freeze-thaw cycles
  • QC DocumentationCOA / HPLC / MS / MSDS
  • Pack Sizes1g / 5g / 10g / 100g / 1KG
  • Stock StatusIn Stock
  • Use StatementResearch use only; not for human/clinical use

Key Molecular Targets & Biological Pathways

Epitalon modulates telomerase, pineal gland function, and circadian hormone regulation — the core axes of aging biology

🧬 Telomerase (TERT) 🧪 Telomere Elongation 🌙 Melatonin Receptors 🌲 Pineal Gland Regulation ☀️ Cortisol Rhythm 🔄 Circadian Clock 🛡️ Oxidative Stress / ROS ⚡ Mitochondrial Function 🧠 Neurogenesis Markers 👀 Retinal Integrity

How Epitalon Works: Telomerase, Circadian & Geroprotective Action

Epitalon exerts its anti-aging effects through three interconnected mechanisms targeting the fundamental biology of cellular aging

1

Telomerase Activation

Epitalon upregulates telomerase reverse transcriptase (TERT) expression and activity in somatic cells. This reactivates the enzyme that elongates telomeres — the protective chromosome caps that shorten with each cell division — counteracting replicative senescence and extending cellular proliferative lifespan.

2

Circadian Rhythm Regulation

As a pineal gland-derived peptide, Epitalon modulates melatonin and cortisol secretion patterns, restoring age-disrupted circadian rhythms. In elderly primates, it normalized melatonin and cortisol profiles, improving sleep-wake cycles and neuroendocrine balance critical for healthy aging.

3

Geroprotective & Antioxidant Action

Epitalon reduces reactive oxygen species (ROS), supports mitochondrial function, and decreases chromosome aberrations. These combined effects — telomere maintenance, hormonal balance, and oxidative stress reduction — produce measurable lifespan extension (12.3% in mice) and tumor suppression.

Research Applications & Disease Models

Epitalon's multi-pathway geroprotective action spans longevity, telomere biology, neuroscience, oncology, and reproductive health

⏳

Anti-Aging & Longevity

Demonstrated 12.3% lifespan increase in mice with reduced chromosome aberrations. Epitalon counteracts replicative senescence through telomerase activation, making it a cornerstone tool for geroscience and lifespan-extension research.

+12.3% Lifespan
🧬

Telomere Biology

Activates telomerase in somatic cells and induces measurable telomere elongation (Khavinson et al., 2003). A key chemical tool for studying telomere dynamics, cellular senescence, and the relationship between telomere length and aging phenotypes.

Telomere Elongation
🎗️

Cancer Prevention

Produced a 6-fold reduction in leukemia incidence and suppressed spontaneous tumor development in mice. Epitalon's tumor-suppressive effects make it relevant for chemoprevention research and studying the telomerase-cancer nexus.

Tumor Suppression
🌙

Circadian Rhythm

Regulates melatonin and cortisol circadian rhythms in elderly primates, restoring age-disrupted neuroendocrine cycles. Relevant for sleep disorders, jet lag, shift-work adaptation, and age-related circadian decline research.

Melatonin / Cortisol
👀

Retinitis Pigmentosa

Preserves visual function and retinal integrity in retinitis pigmentosa models. Epitalon's neuroprotective and antioxidant properties support photoreceptor survival, making it a candidate for inherited retinal degeneration research.

Retinal Degeneration
🧠

Neuroprotection

Promotes neuronal differentiation and upregulates neurogenesis markers. Epitalon's neurotrophic effects are relevant for cognitive aging, neurodegenerative disease models, and neural repair research.

Neurogenesis
🧫

Reproductive Health

Improves oocyte quality and reduces spindle defects in reproductive aging models. Relevant for studying age-related fertility decline, oocyte competence, and reproductive senescence mechanisms.

Oocyte Quality
⚡

Oxidative Stress & Mitochondria

Reduces reactive oxygen species (ROS) and supports mitochondrial function. Epitalon's antioxidant action complements its telomerase activity, addressing multiple hallmarks of aging simultaneously.

ROS Reduction

Key Literature & Landmark Publications

Seminal papers on Epitalon's discovery, telomerase activation, and geroprotective applications

Khavinson VKh, Bondarev IE, Butyugov AA, Smirnova EN. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bulletin of Experimental Biology and Medicine. 2003;135(6):590-592.
doi: 10.1023/A:1025495801403
Khavinson VKh, Morozov VG. Peptides and ageing. Neuro Endocrinology Letters. 2002;23(Suppl 3):11-144.
Comprehensive review — pineal peptides and longevity
Khavinson VKh, et al. Peptide regulation of aging. Bulletin of Experimental Biology and Medicine.
Lifespan studies; 12.3% increase in mice
Staquicini FI, et al. Identification of Epitalon in illegal pharmaceutical preparations. Drug Testing and Analysis. 2015;7(10):879-887.
Analytical characterization of Epitalon
Khavinson VKh, Kopylov AT, Vaskovsky BV, Ryzhak GA. Identification of peptide AEDG in the polypeptide fraction of the pineal gland. Bulletin of Experimental Biology and Medicine.
Endogenous origin of AEDG sequence
Khavinson VKh, Lin'kova NS, et al. Peptide regulation of gene expression. Bulletin of Experimental Biology and Medicine.
Molecular mechanisms; telomerase and neurogenesis

Available Sizes & Ordering

Research-grade Epitalon (CAS 307297-39-8) with full QC documentation; research packs and bulk custom quantities supported

TierPack SizeStock StatusSuitable ForLead Time
Standard1 gIn StockBiochemical / cell-based assaysSame/next-day ship
Medium5 gIn StockIn vivo pharmacology, long-term studiesSame/next-day ship
Large10 gIn StockMulti-lab collaborations, HTSSame/next-day ship
Bulk100 gIn StockProcess development, scale-upQuote to confirm
Industrial1 KGMade to orderPilot/production scale, CMO supplyBatch delivery

For exact pricing and availability please contact us for a quote. Bulk orders qualify for tiered discounts.

Frequently Asked Questions (FAQ)

What is Epitalon (CAS 307297-39-8)?
Epitalon (also known as Epithalon or Epithalone) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly (AEDG) (C14H22N4O9, MW 390.35). It is a telomerase activator and pineal gland peptide that upregulates telomerase activity, elongates telomeres, and regulates melatonin and cortisol circadian rhythms. Originally developed from pineal gland extract research by Professor Vladimir Khavinson, it has demonstrated geroprotective effects including a 12.3% lifespan increase in mice.
How does Epitalon activate telomerase?
Epitalon upregulates telomerase reverse transcriptase (TERT) expression and activity in somatic cells, enabling the elongation of telomeres — the protective caps at chromosome ends that shorten with each cell division. By activating telomerase, Epitalon counteracts replicative senescence and extends the proliferative lifespan of cells. This was demonstrated in human somatic cells (Khavinson et al., Bull Exp Biol Med 2003), showing that Epitalon induces both telomerase activity and measurable telomere elongation.
Is there human evidence for Epitalon's effects?
Most published data on Epitalon comes from preclinical studies (mice, rats, primates) and Russian clinical research by Khavinson and colleagues. Key findings include a 12.3% lifespan increase in mice, a 6-fold reduction in leukemia incidence, regulation of melatonin and cortisol circadian rhythms in elderly primates, and preservation of retinal function in retinitis pigmentosa models. While human clinical data exists in the Russian literature, large-scale Western clinical trials have not been conducted. Epitalon is sold for research use only.
What dosing protocols are used in Epitalon research?
Dosing protocols vary by research model and objective. In animal studies, Epitalon has been administered via subcutaneous injection, typically in short courses (e.g., 5-day cycles). For in vitro telomerase assays, concentrations are determined based on cell type and experimental design. Researchers should consult primary literature for model-specific protocols. As a peptide, Epitalon should be reconstituted in sterile water or DMSO and stored at -20°C, protected from light and moisture. Contact us for formulation guidance.
Is Epitalon safe? What are the known side effects?
In published preclinical studies, Epitalon has shown a favorable safety profile with no significant toxicity reported at research doses. Long-term administration in animal models did not produce adverse effects on major organ systems. However, Epitalon is sold for research use only and has not been evaluated by the FDA or EMA for human therapeutic use. Proper handling, storage (-20°C, protected from light), and adherence to laboratory safety protocols are essential.
What is the relationship between Epitalon and the pineal gland?
Epitalon was developed based on research into pineal gland peptides by Professor Vladimir Khavinson. The AEDG sequence was identified in polypeptide fractions extracted from the pineal gland. The pineal gland regulates melatonin production and circadian rhythms, both of which decline with age. Epitalon's ability to restore melatonin and cortisol rhythms in elderly animals reflects its pineal origin and makes it a key tool for studying neuroendocrine aging.
How does Epitalon's cancer prevention data compare to other geroprotectors?
Epitalon produced a 6-fold reduction in spontaneous leukemia incidence in mice, along with suppression of other spontaneous tumors. This is notable because telomerase activation is often considered a double-edged sword in cancer (tumor cells use telomerase for immortality). Epitalon's tumor-suppressive effects suggest its geroprotective actions extend beyond telomerase to include immune modulation, antioxidant activity, and genomic stability maintenance — distinguishing it from direct telomerase activators that may carry oncogenic risk.
Is QC documentation provided? Can I request a sample?
Every batch ships with a Certificate of Analysis (COA) including HPLC purity and MS confirmation. MSDS/SDS, solubility datasheets, and Certificates of Origin are available on request. Sample evaluation policy is available for qualified institutions — please contact us for details.

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Research-grade Epitalon (CAS 307297-39-8) — purity ≥98%, COA included
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