Nutrabiotech Dihexa 98% 1G Powder, high purity Dihexa PNB-0408 peptide powder, HGF/c-Met signaling potentiator, synaptogenic neurorestorative agent, cognitive repair and neuroplasticity research raw material

CAS 1401708-83-5 Dihexa PNB-0408 Powder Potent Cognitive Enhancer Peptide for Neurodegenerative Disease Research

Premium Dihexa PNB-0408 peptide powder CAS 1401708-83-5, highly potent brain-permeable nootropic compound activating HGF/c-Met pathway. Ideal for neuroprotection, synaptic repair and anti-Alzheimer research.
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Dihexa (CAS 1401708-83-5) Angiotensin IV Analog | HGF/c-Met Potentiator & Synaptogenic Cognitive-Enhancement Compound

Dihexa CAS 1401708-83-5
Angiotensin IV Analog & HGF/c-Met Potentiator (Cognitive Enhancer)

Dihexa (CAS 1401708-83-5) is an orally active, blood-brain-barrier-permeable angiotensin IV analog (N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide) that binds hepatocyte growth factor (HGF) with high affinity (Kd 65 pM) and potently potentiates HGF/c-Met signaling. It promotes hippocampal spinogenesis and synaptogenesis and is studied for cognitive enhancement and Alzheimer's disease. Molecular formula C27H44N4O5, MW 504.66. Research-grade with COA.

HGF/c-Met Angiotensin IV Synaptogenesis Cognitive Enhancer Nootropic Alzheimer BBB-Permeable Spinogenesis
Request a Quote Technical Specs
504.66
MW (C27H44N4O5)
65 pM
HGF Kd
BBB
Permeable / Oral

Molecular Information

Name: Dihexa
CAS: 1401708-83-5
Formula: C27H44N4O5
MW: 504.66 g/mol
Class: Angiotensin IV peptidomimetic
Sequence: Hexanoyl-Tyr-Ile-Ahx-NH2
Target: HGF / c-Met (potentiation)
Kd: 65 pM (HGF)
Route: Oral; BBB-permeable
Appearance: White to off-white powder
Synonyms: N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide
Storage: -20 C
🧪
CAS Number
1401708-83-5
⚖️
Molecular Weight
504.66
🎯
Primary Activity
HGF/c-Met Potentiator
✅
Purity
≥98%

Product Technical Specifications

Complete physicochemical properties and QC parameters for Dihexa (CAS 1401708-83-5)

📋 Physicochemical Properties

  • Product NameDihexa
  • Sequence / IUPACN-hexanoic-Tyr-Ile-(6)-aminohexanoic amide (Hexanoyl-Tyr-Ile-Ahx-NH2)
  • CAS Number1401708-83-5
  • SynonymsPN-271; N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide
  • Molecular FormulaC27H44N4O5
  • Molecular Weight504.66 g/mol
  • SourceSynthetic peptidomimetic (angiotensin IV analog)
  • AppearanceWhite to off-white powder
  • Melting PointNot reported
  • Water SolubilityLow (amphipathic); formulate in solvent/DMSO
  • Organic SolubilityDMSO ~100 mg/mL
  • Compound ClassAngiotensin IV analog / HGF-c-Met potentiator
  • HS Code2934.99

🔬 Quality Control & Handling

  • Purity (HPLC)≥98%
  • FormPowder / lyophilized
  • Primary TargetHGF (hepatocyte growth factor) / c-Met potentiator
  • Pathway Readoutc-Met phosphorylation; spinogenesis / synaptogenesis
  • SelectivityHigh-affinity HGF binding (Kd 65 pM)
  • Storage-20 C, sealed, protect from light (desiccated)
  • Solution StabilityAliquot DMSO stocks; avoid freeze-thaw
  • ShippingBlue ice / cold chain recommended
  • QC DocumentationCOA / HPLC / MS / MSDS
  • Pack Sizes1g / 5g / 10g / 100g / 1KG
  • Stock StatusIn Stock
  • Use StatementResearch use only; not for human/clinical use

Key Molecular Targets & Pathway Nodes

Dihexa's signature is potentiation of the HGF/c-Met trophic axis — a synaptogenic pathway distinct from conventional neurotransmitter-targeted nootropics.

🧬 HGF (Hepatocyte Growth Factor) 🧬 c-Met (HGFR, RTK) 🧠 Hippocampus / Dendritic Spines 🔗 Spinogenesis & Synaptogenesis 🧠 Cognition / Memory 🧠 Neuroplasticity 🧬 Angiotensin IV (AngIV) System 🧠 Alzheimer's Models 🔬 p-Met (Tyr1234/1235) 🧬 Axon Guidance / Migration 🩸 Angiogenesis (HGF) 🧫 Neurogenesis

How Dihexa Works: Amplifying the HGF/c-Met Trophic Signal

Rather than hijacking a receptor, Dihexa makes endogenous HGF a far better activator of c-Met

1

High-Affinity HGF Binding

Dihexa is a small-molecule angiotensin IV analog that binds hepatocyte growth factor (HGF) with very high affinity (Kd ~65 pM) — remarkably tighter than HGF's own receptor. This binding is the molecular anchor of its activity.

2

Potentiation of c-Met Signaling

By binding HGF, dihexa potentiates HGF's ability to activate its receptor tyrosine kinase c-Met (measured as increased p-Met Tyr1234/1235). In effect it is an allosteric co-agonist: at subthreshold HGF it augments c-Met phosphorylation and the HGF-dependent cell-scattering/migration response.

3

Spinogenesis, Synaptogenesis & Cognition

HGF/c-Met signaling drives dendritic spine and synapse formation. Dihexa replicates HGF's ability to induce hippocampal spinogenesis and synaptogenesis, and in vivo it improves spatial learning (reversing scopolamine deficits and aging-related impairment) — the basis of its procognitive profile and Alzheimer's research interest.

⚖️ Dihexa vs Other Cognitive Research Agents

  • Dihexa (this)HGF/c-Met potentiator; synaptogenic; BBB-permeable
  • Semax / SelankMelanocortin/BDNF & GABAergic peptides
  • Traditional nootropicsCholinergic / glutamatergic targets
  • Unique MechanismAmplifies endogenous HGF (not a receptor agonist)
  • Research UseSynaptogenesis & dementia models
  • DeliveryOrally active (metabolically stabilized analog)

♻️ Downstream Biological Consequences

  • c-MetIncreased p-Met (Tyr1234/1235)
  • NeuronalDendritic spine & synapse formation
  • PlasticityEnhanced long-term potentiation (LTP)
  • CognitionImproved spatial learning/memory
  • AngiogenesisHGF-driven (context-dependent)
  • DiseaseProcognitive in Alzheimer's models

Research Applications & Models

Dihexa occupies a unique niche: a synaptogenic, HGF/c-Met-targeted cognitive enhancer with oral activity and brain penetration.

🧠

Cognitive & Memory Research

Studied for procognitive effects — reversing scopolamine-induced and aging-related spatial-learning deficits, and enhancing memory in rodent models via synaptic plasticity.

Memory / LTP
🧠

Alzheimer's Disease Models

Investigated as an antidementia agent leveraging synaptogenesis to counter synapse loss, a core pathological feature of Alzheimer's disease.

Synapse Loss
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Synaptogenesis / Spinogenesis

A reference tool to induce hippocampal dendritic spines and synapses in culture and in vivo, isolating HGF/c-Met-dependent plasticity.

Spine Formation
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HGF / c-Met Pharmacology

Used to study HGF-c-Met potentiation, receptor phosphorylation and the distinction between receptor agonists and allosteric co-activators.

c-Met Signaling
🧠

Neuroplasticity & Repair

Explored for neural repair and plasticity after injury, where HGF/c-Met trophic signaling supports neuronal connectivity.

Neurorepair
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Angiotensin IV System

Probes the lesser-known AngIV/AT4 receptor axis and its cognitive and cerebrovascular roles, distinct from classical ACE/AT1 pathways.

AngIV / AT4
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Peptidomimetic Stability

As a metabolically stabilized AngIV analog (capped termini), it exemplifies orally active peptidomimetic design resistant to aminopeptidases.

Peptidomimetic
🧫

Neurogenesis Models

HGF/c-Met signaling also influences neurogenesis and migration; dihexa is used to probe these trophic programs in vitro.

Neurogenesis

Key Literature & Landmark Publications

Key references on angiotensin IV analogs and HGF/c-Met procognitive effects.

McCoy AT, et al. Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents. J Pharmacol Exp Ther. 2013;344(1):141-54.
doi: 10.1124/jpet.112.199349
Benoist CC, et al. The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system. J Pharmacol Exp Ther. 2014;351(2):390-402.
doi: 10.1124/jpet.114.216242
Wright JW, et al. Angiotensin IV and the AT4 receptor in cognition and cerebrovascular regulation. (AngIV review).
Landmark reference
Review. HGF/c-Met in synaptic plasticity and neurodegenerative disease.
Landmark reference
Investigator report. Dihexa pharmacokinetics and brain penetration.
Landmark reference

Available Sizes & Ordering

Research-grade Dihexa (CAS 1401708-83-5) with full QC documentation; standard packs and bulk custom quantities supported.

TierPack SizeStock StatusSuitable ForLead Time
Standard1gIn StockHGF/c-Met & synaptogenesis assaysSame/next-day ship
Medium5gIn StockCognitive & Alzheimer's modelsSame/next-day ship
Large10gIn StockIn vivo behavioral & plasticity studiesSame/next-day ship
Bulk100gIn StockFormulation & process developmentQuote to confirm
Industrial1KGMade to orderPilot/production scale, CMO supplyBatch delivery

💡 Reference sizes shown above; for exact pricing and availability please contact us for a quote. Bulk orders qualify for tiered discounts.

Frequently Asked Questions (FAQ)

What is Dihexa?
Dihexa (CAS 1401708-83-5) is an orally active, blood-brain-barrier-permeable angiotensin IV analog — chemically N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide (Hexanoyl-Tyr-Ile-Ahx-NH2). It binds hepatocyte growth factor (HGF) with very high affinity (Kd ~65 pM) and potently potentiates HGF/c-Met signaling, driving synaptogenesis. Formula C27H44N4O5, MW 504.66. It is studied for cognitive enhancement and Alzheimer's disease.
How does Dihexa enhance cognition?
Rather than acting on a classical neurotransmitter receptor, dihexa amplifies the HGF/c-Met trophic axis. HGF/c-Met signaling promotes dendritic spine and synapse formation; dihexa boosts c-Met phosphorylation and replicates HGF's synaptogenic effect in hippocampus, improving spatial learning and memory in models (including reversal of scopolamine and aging deficits).
Is Dihexa a c-Met agonist?
No — it is a potentiating co-factor, not a direct receptor agonist. Dihexa binds HGF, not c-Met, and makes endogenous HGF a more effective activator of c-Met. At subthreshold HGF it augments receptor phosphorylation and downstream responses; alone at low concentrations it does not strongly activate c-Met.
How is it different from Semax or Selank?
Semax and Selank act on melanocortin/BDNF and GABAergic systems respectively. Dihexa is unique in targeting the HGF/c-Met synaptogenic pathway — a mechanism aimed at building new synapses rather than modulating acute neurotransmission. It is also orally active, being a metabolically stabilized peptide analog.
What readouts confirm activity?
c-Met phosphorylation (p-Met Tyr1234/1235) by Western blot; dendritic spine/synapse counts (Golgi, imaging); and behavioral readouts (Morris water maze, novel-object recognition). Binding affinity is confirmed by HGF Kd (~65 pM).
How soluble is Dihexa and how should it be prepared?
Dihexa is soluble in DMSO (~100 mg/mL) and amphipathic; aqueous solubility is low, so formulate in DMSO or suitable vehicles. For cell assays dilute DMSO stock (final DMSO ≤0.1% v/v); for in vivo use validated vehicles. Store solid/lyophilized at -20 C, desiccated and protected from light; aliquot stocks.
Is QC documentation provided?
Every batch ships with a Certificate of Analysis (COA) including HPLC purity, MS and structural confirmation. MSDS/SDS available on request. Sample evaluation available for qualified institutions — please contact us.

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Research-grade Dihexa (CAS 1401708-83-5) — purity ≥98% HPLC, COA included
The synaptogenic angiotensin IV analog that amplifies the HGF/c-Met cognitive axis — request a quote today

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Weight 1 g

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