GHK Cu Copper Peptide CAS 49557-75-7 high purity peptide powder for skincare and cosmetic formula research

CAS 89030-95-5 Copper Tripeptide GHK-Cu Powder Blue Copper Peptide for Skin Repair and Anti-Aging Cosmetics

Premium 98% Copper Tripeptide-1 crystalline powder CAS 89030-95-5, also known as GHK-Cu blue copper peptide. Powerful antioxidant, anti-aging and skin repair active ingredient widely used in high-end cosmetic formulations.
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GHK-Cu (CAS 89030-95-5) Copper Peptide | Wound-Healing, Angiogenesis & Collagen-Regenerating Research Compound

GHK-Cu CAS 89030-95-5
Copper-Bound Tripeptide (Gly-His-Lys) — Regenerative & Anti-Inflammatory Peptide

GHK-Cu (CAS 89030-95-5) is the naturally occurring copper(II) complex of the tripeptide glycyl-L-histidyl-L-lysine, a powerful tissue-regenerative and anti-inflammatory signal. It upregulates collagen, elastin, GAGs and angiogenesis. Molecular formula C14H21CuN6O4, MW 400.91. Research-grade with COA.

GHK-Cu Copper Peptide Wound Healing Angiogenesis Collagen Anti-Aging Skin Regeneration Hair Growth
Request a Quote Technical Specs
400.91
MW (C14H21CuN6O4)
Cu2+
1:1 tripeptide complex
ECM
Collagen/elastin ↑

Molecular Information

Name: GHK-Cu
CAS: 89030-95-5
Formula: C14H21CuN6O4
MW: 400.91 g/mol
Class: Copper(II) tripeptide complex
Sequence: Gly-His-Lys (copper-bound)
Target: ECM regeneration / angiogenesis
Activity: Collagen/elastin/GAG ↑
Appearance: Light blue to blue powder
Synonyms: GHK Copper / Prezatide copper
Storage: 2-8 C / -20 C, inert gas
🧪
CAS Number
89030-95-5
⚖️
Molecular Weight
400.91
🎯
Primary Activity
Copper Peptide
✅
Purity
≥98%

Product Technical Specifications

Complete physicochemical properties and QC parameters for GHK-Cu (CAS 89030-95-5)

📋 Physicochemical Properties

  • Product NameGHK-Cu (Copper Tripeptide-1)
  • IUPAC Core[N2-(N-glycyl-L-histidyl)-L-lysinato(2-)]copper
  • CAS Number89030-95-5
  • SynonymsGHK Copper; Prezatide copper; Gly-His-Lys-Cu
  • Molecular FormulaC14H21CuN6O4
  • Molecular Weight400.91 g/mol
  • SourceSynthetic peptide-copper complex
  • AppearanceLight blue to blue powder / lyophilate
  • Melting PointNot reported
  • Water SolubilitySoluble
  • Organic SolubilityDMSO soluble
  • Compound ClassCopper(II) tripeptide / regenerative peptide
  • HS Code2937.90

🔬 Quality Control & Handling

  • Purity (HPLC)≥98%
  • FormLyophilized powder
  • Primary TargetTissue regeneration, ECM & angiogenic signaling
  • Pathway ReadoutCollagen/elastin/GAG mRNA ↑; MMP-2; angiogenesis; SOD
  • SelectivityMulti-gene regenerative regulator; not a single kinase
  • Storage Condition2-8 C (inert gas) / -20 C, sealed, protect from light
  • Solution StabilityReconstitute in water/ saline; use fresh; avoid acidic pH
  • ShippingCold pack / blue ice recommended
  • QC DocumentationCOA / HPLC / MS / MSDS
  • Pack Sizes1g / 5g / 10g / 100g / 1KG
  • Stock StatusIn Stock
  • Use StatementResearch use only; not for human/clinical use

Key Molecular Targets & Pathway Nodes

GHK-Cu is not a single-target inhibitor; it is a pleiotropic regenerative signal that orchestrates extracellular-matrix building, angiogenesis and inflammation resolution across multiple cell types.

🧬 Fibroblasts (ECM) 🧬 Keratinocytes 🩸 Endothelial / Capillary Cells 🦴 Osteoblasts / Bone 🧠 Neuronal & Glial 🔗 Collagen I / III 🔗 Elastin & Proteoglycans 🔗 Glycosaminoglycans (GAGs) 🔬 MMP-2 (matrix metalloproteinase) 🛡️ Inflammatory Cytokines 🧪 Antioxidant (SOD) ⚡ Angiogenesis / VEGF

How GHK-Cu Works: A Multi-Gene Regenerative Signal

GHK-Cu delivers copper to tissues and reprograms gene expression toward repair, ECM synthesis, angiogenesis and inflammation resolution

1

Copper Delivery & Cellular Uptake

The GHK tripeptide binds Cu2+ in a 1:1 complex. GHK-Cu carries copper into tissues where it participates in copper-dependent enzymes and acts as a signaling complex that cells take up to initiate repair programs.

2

ECM & Collagen Gene Upregulation

At ~10-9 M GHK-Cu increases fibroblast mRNA for collagen, elastin, proteoglycans and glycosaminoglycans, rebuilding the extracellular matrix. It also raises secreted pro-MMP-2, balancing matrix remodeling rather than merely depositing scar.

3

Angiogenesis, Anti-Inflammation & Antioxidant Defense

GHK-Cu acts as a chemoattractant for capillary cells, inducing angiogenesis (e.g., in rabbit models), lowers ROS, IL-6 and TNF-α in macrophages, and boosts antioxidant enzymes such as SOD — together resolving inflammation and supporting regeneration of skin, nerve, bone and liver.

⚖️ GHK-Cu vs Other Regenerative Peptides

  • GHK-Cu (this product)Cu2+-bound tripeptide; multi-gene regenerative signal
  • GHK (metal-free)Same tripeptide without copper; weaker bioactivity
  • BPC-157Pentadecapeptide; gut/ tendon repair axis
  • Shared ThemeEndogenous tissue-repair peptides
  • Key DistinctionGHK-Cu uniquely requires Cu2+ coordination
  • OutputECM synthesis + angiogenesis + anti-inflammation

♻️ Downstream Biological Consequences

  • MatrixCollagen I/III, elastin, GAGs ↑
  • VesselsCapillary formation / angiogenesis ↑
  • InflammationROS, IL-6, TNF-α ↓
  • AntioxidantSOD & antioxidant enzymes ↑
  • RemodelingBalanced MMP-2 / matrix turnover
  • TissueSkin, nerve, bone, liver regeneration

Research Applications & Models

From dermatology to orthopedics and hair science, GHK-Cu is a foundational regenerative-biology tool.

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Wound Healing & Scar Reduction

The classic use: GHK-Cu accelerates healing in diabetic ulcers, surgical and burn models and reduces scar by balancing collagen and MMP activity.

ECM / Repair
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Skin Regeneration & Anti-Aging

Upregulates dermal collagen/elastin and GAGs; studied for wrinkles, elasticity and photo-damage in skin models.

Dermal ECM
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Angiogenesis Research

Used as a capillary chemoattractant to study new-vessel formation in wound and ischemia models.

Angiogenesis
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Hair Follicle Stimulation

Investigated for reactivating follicle growth and improving hair density in dermal-papilla models.

Hair / Follicle
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Bone & Connective-Tissue Repair

Studied for calvarial/ bone-defect regeneration and tendon/ligament matrix repair.

Osteo / Connective
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Nerve & Hepatic Protection

Explored for neuroprotection, glial modulation and protecting liver from oxidative injury.

Neuro / Hepatic

Key Literature & Landmark Publications

The regenerative biology and clinical implications of GHK-Cu.

Pickart L, Margolina A. Regenerative and protective actions of the GHK-Cu peptide in the light of the new gene data. Int J Mol Sci. 2018;19(1):7.
doi: 10.3390/ijms19010007
Campbell L, et al. Effects of copper peptides on skin and hair regeneration. (Review).
Landmark reference
Ahmed S, et al. Copper tripeptide as a regenerative agent. (Matrix & angiogenesis).
Landmark reference
ChemBL / supplier profile: GHK-Cu increases collagen, elastin, GAGs & MMP-2 in fibroblasts; induces angiogenesis.
Landmark reference
Human-plasma-derived GHK decreases with age; maximal biologic effect near 10-9 M.
Landmark reference

Available Sizes & Ordering

Research-grade GHK-Cu (CAS 89030-95-5) with full QC documentation; standard packs and bulk custom quantities supported.

TierPack SizeStock StatusSuitable ForLead Time
Standard1gIn StockWound-healing & skin/ECM assaysCold chain
Medium5gIn StockDermal, angiogenic & hair modelsCold chain
Large10gIn StockLong-term in vivo & formulation studiesCold chain
Bulk100gIn StockFormulation & process developmentQuote to confirm
Industrial1KGMade to orderPilot/production scale, CMO supplyBatch delivery

💡 Reference sizes shown above; for exact pricing and availability please contact us for a quote. Bulk orders qualify for tiered discounts.

Frequently Asked Questions (FAQ)

What is GHK-Cu and what does it do?
GHK-Cu (CAS 89030-95-5) is the copper(II) complex of the tripeptide glycyl-L-histidyl-L-lysine (GHK) — a naturally occurring, blue regenerative peptide. It upregulates collagen, elastin, proteoglycans and GAGs, induces angiogenesis and resolves inflammation. Formula C14H21CuN6O4, MW 400.91; optimal activity near 10-9 M.
How does GHK-Cu promote wound healing and skin repair?
GHK-Cu carries copper into tissue and reprograms fibroblasts to make more ECM (collagen I/III, elastin, GAGs) while raising secreted pro-MMP-2 for balanced remodeling. It also attracts capillary cells (angiogenesis) and lowers ROS/cytokines, accelerating healing of ulcers, burns and surgical wounds with less scarring.
Is GHK-Cu the same as plain GHK peptide?
No — the copper coordination is essential. Metal-free GHK is far less active; the Cu2+ complex is what drives the regenerative gene program and antioxidant (SOD) effects. Keep solutions near neutral pH, as strong acid can strip the copper ion.
What are the key experimental readouts?
Readouts include collagen/elastin/GAG mRNA (qPCR), MMP-2 by zymography, capillary-tube/fibroblast chemotaxis for angiogenesis, SOD/antioxidant assays, and wound-closure or scar models in vivo.
How soluble is GHK-Cu and how should it be prepared?
GHK-Cu is water- and DMSO-soluble and is typically supplied as a light-blue lyophilate. Reconstitute in sterile water or saline, use fresh, and avoid acidic conditions that free copper. Store at 2-8 C under inert gas (or -20 C) protected from light; working solutions are best used promptly.
Is QC documentation provided?
Every batch ships with a Certificate of Analysis (COA) including HPLC purity, MS/structural confirmation and copper content. MSDS/SDS and Certificates of Origin are available on request. Sample evaluation is available for qualified institutions — please contact us.

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Research-grade GHK-Cu (CAS 89030-95-5) — purity ≥98% HPLC, COA included
The blue copper peptide that drives wound healing, angiogenesis and ECM/collagen regeneration — request a quote today

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