Nutrabiotech Daprodustat 98% 1G Powder, high purity Daprodustat GSK1278863 powder, second-generation pan HIF-PH inhibitor, HIF-1α HIF-2α stabilizer, EPO and iron metabolism regulation research raw material

Daprodustat CAS 960539-70-2 98% Purity HIF-PH Inhibitor Powder

High purity Daprodustat powder CAS 960539-70-2 with 98% HPLC purity. Also known as GSK1278863, a potent oral HIF-PH inhibitor for CKD anemia research, factory bulk supply, full certificates and fast global delivery.
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Daprodustat GSK1278863 (CAS 960539-70-2) HIF-PH Inhibitor | Anemia / CKD Research

Daprodustat CAS 960539-70-2
Oral HIF Prolyl Hydroxylase Inhibitor (Anemia / CKD)

Daprodustat (CAS 960539-70-2), also GSK1278863, is an oral HIF prolyl hydroxylase (HIF-PH) inhibitor that stabilizes HIF-α, driving endogenous erythropoietin (EPO) production, iron mobilization and erythroid maturation — a hypoxia-mimetic mechanism for anemia, especially in chronic kidney disease. Formula C19H27N3O6, MW 393.4. Research-grade with COA.

HIF-PH InhibitorAnemiaCKDDaprodustatGSK1278863HypoxiaEPOErythropoiesis
Request a Quote Technical Specs
393.4
MW (C19H27N3O6)
≥98%
Purity (HPLC)
HIF-PH
Hypoxia mimetic

Molecular Information

Name: Daprodustat (GSK1278863)
CAS: 960539-70-2
Formula: C19H27N3O6
MW: 393.4 g/mol
Class: HIF prolyl hydroxylase inhibitor
Core: Dicyclohexyl barbituric acid glycine conjugate
Target: HIF-PH (PHD1/2/3)
Activity: HIF-α stabilization; EPO induction
MP: Not firmly reported
Appearance: White to off-white powder
Synonyms: GSK1278863
Storage: -20°C, protect from light
960539-70-2
🧪
CAS Number
393.4
⚖️
Molecular Weight
HIF-PH Inhibitor
🎯
Primary Activity
≥98%
✅
Purity

Product Technical Specifications

Complete physicochemical properties and QC parameters for Daprodustat (CAS 960539-70-2)

📋 Physicochemical Properties

  • Product NameDaprodustat (GSK1278863)
  • IUPAC Name2-[(1,3-dicyclohexyl-2,4,6-trioxo-1,3-diazinane-5-carbonyl)amino]acetic acid
  • CAS Number960539-70-2
  • SynonymsDaprodustat; GSK1278863
  • Molecular FormulaC19H27N3O6
  • Molecular Weight393.4 g/mol
  • SourceSynthetic HIF-PH inhibitor
  • AppearanceWhite to off-white powder
  • Water SolubilityLow
  • Organic SolubilityDMSO; some aqueous buffers
  • Compound ClassHIF prolyl hydroxylase inhibitor / anemia agent
  • HS Code2934.99

🔬 Quality Control & Handling

  • Purity (HPLC)≥98%
  • FormCrystalline powder
  • Primary TargetHIF prolyl hydroxylase (PHD1/2/3)
  • Assay ReadoutEPO; HIF-α stabilization
  • SelectivityOral HIF-PH (hypoxia mimetic)
  • Storage Condition-20°C, sealed, protect from light
  • Solution StabilityDMSO stock stable weeks at -20°C
  • ShippingRoom temp / cold chain
  • QC DocumentationCOA / HPLC / NMR / MS / MSDS
  • Pack Sizes100mg / 500mg / 1g / 5g / 10g
  • Stock StatusIn Stock
  • Use StatementResearch / investigational; not for human use

Key Molecular Targets & Pathway Nodes

Daprodustat engages the molecular machinery and pathway nodes that define its research utility.

🧬 HIF-PH (PHD1/2/3) 🧬 HIF-α stabilization 🧪 EPO production 💧 Iron metabolism (hepcidin) 🦴 Erythropoiesis 🧭 CKD / anemia 🧪 Hypoxia response 🔬 HIF pathway 💧 Oxygen sensing 🧬 Gene transcription

How Daprodustat Works: Mimicking Hypoxia to Make Red Cells

Daprodustat blocks HIF-PH, stabilizing HIF-α so the body makes its own erythropoietin

1

Inhibition of HIF Prolyl Hydroxylases

Daprodustat blocks the oxygen-sensitive HIF-PH (PHD) enzymes that normally hydroxylate and target HIF-α for degradation under normoxia.

2

Stabilization of HIF-α & Endogenous EPO

With HIF-PH inhibited, HIF-α accumulates and drives transcription of erythropoietin (EPO) and other hypoxia-response genes — a physiologic, hypoxia-mimetic signal.

3

Iron Mobilization & Erythroid Maturation

The HIF program also lowers hepcidin and improves iron availability and utilization, maturing red cells to correct anemia (notably in CKD), distinct from injected EPO.

⚖️ Daprodustat vs Comparators

  • Daprodustat (this product)Oral HIF-PH inhibitor; EPO induction
  • Erythropoietin (EPO)Exogenous injectable hormone
  • Roxadustat / vadadustatOther HIF-PH inhibitors
  • Selective EdgeOral; endogenous EPO & iron handling
  • Research NicheAnemia / CKD & hypoxia biology

♻️ Downstream Biological Consequences

  • EnzymeHIF-PH blocked
  • TranscriptionHIF-α target genes on
  • HormoneEndogenous EPO rises
  • IronHepcidin down; utilization up
  • Red cellsErythropoiesis matures
  • DiseaseCKD anemia corrected

Research Applications & Models

Daprodustat is a key oral HIF-PH tool for anemia and hypoxia biology.

🧭

Anemia / CKD Research

The reference oral HIF-PH approach to anemia of chronic kidney disease.

Anemia / CKD
🧪

HIF Pathway Studies

Probes oxygen sensing and HIF-α stabilization.

HIF
🦴

Erythropoiesis Models

Measures EPO, reticulocytes and red-cell maturation.

Erythropoiesis
💧

Iron-Metabolism Research

Investigates hepcidin and iron utilization.

Iron
🧪

Hypoxia-Mimetic Assays

Compares to EPO and other HIF-PH agents.

Hypoxia
🔬

Comparative Profiling

HIF-PH inhibitor selectivity and PK.

Screening

Key Literature & Landmark Publications

Landmark work on HIF-PH inhibitors and anemia of CKD.

Investigator reports. Daprodustat (GSK1278863) HIF-PH inhibition in CKD anemia.
Landmark reference
Review. HIF prolyl hydroxylase inhibitors for anemia.
Landmark reference
Preclinical reports. Daprodustat EPO induction and iron handling.
Landmark reference
Clinical literature. Oral HIF-PH vs erythropoiesis-stimulating agents.
Landmark reference
Structure-activity literature. Daprodustat optimization.
Landmark reference

Available Sizes & Ordering

Research-grade Daprodustat / GSK1278863 (CAS 960539-70-2) with full QC documentation; standard packs and bulk custom quantities supported.

TierPack SizeStock StatusSuitable ForLead Time
Standard100mgIn StockHIF / anemia assaysSame/next-day ship
Medium500mgIn StockCell & pathway studiesSame/next-day ship
Large1gIn StockIn vivo anemia modelsSame/next-day ship
Bulk5gIn StockScreening & formulationQuote to confirm
Industrial10g+Made to orderProcess developmentWe can quote

💡 Reference sizes shown above; for exact pricing and availability please contact us for a quote. Bulk orders qualify for tiered discounts.

Frequently Asked Questions (FAQ)

What is daprodustat and what does it inhibit?
Daprodustat (CAS 960539-70-2), also GSK1278863, is an oral HIF prolyl hydroxylase (HIF-PH/PHD) inhibitor that stabilizes HIF-α to induce endogenous erythropoietin. Formula C19H27N3O6, MW 393.4.
How does it treat anemia differently from EPO?
Instead of injecting erythropoietin, daprodustat blocks HIF-PH so the body makes its own EPO and improves iron utilization — a hypoxia-mimetic, oral mechanism suited to CKD anemia.
What models use daprodustat?
Anemia of chronic kidney disease, erythropoiesis, iron-metabolism (hepcidin) and hypoxia-response research.
What readouts confirm activity?
HIF-α stabilization, EPO and reticulocyte elevation, hepcidin suppression, and red-cell/hemoglobin readouts.
How soluble is daprodustat and how should it be prepared?
It is soluble in DMSO and some aqueous buffers; poorly in water. Prepare a DMSO stock, dilute into medium (final DMSO ≤0.1% v/v), and store at -20°C protected from light.
Is QC documentation provided?
Every batch ships with a Certificate of Analysis (COA) including HPLC purity, NMR structural confirmation and MS data; MSDS/SDS and Certificates of Origin are available on request.

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Research-grade Daprodustat (CAS 960539-70-2) — purity ≥98% HPLC, COA included
HIF-PH Inhibitor — request a quote today

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Weight 1 g

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