Nutrabiotech Lasmiditan 98% 1G Powder, 98% high purity Lasmiditan powder, selective 5-HT1F receptor agonist, CGRP release inhibitor, non-vasoconstrictive migraine research raw material

Lasmiditan CAS 439239-90-4 98% Purity Reyvow Raw Material Powder

High purity Lasmiditan powder CAS 439239-90-4 with 98% HPLC purity. Selective 5-HT1F receptor agonist for migraine treatment research, factory bulk supply, complete COA/MSDS, fast global delivery for pharmaceutical lab use.
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Lasmiditan (CAS 439239-90-4) Selective 5-HT1F Agonist | Acute Migraine (LY-573144)

Lasmiditan CAS 439239-90-4
Selective 5-HT1F Agonist (Acute Migraine)

Lasmiditan (CAS 439239-90-4), formerly LY-573144, is a highly selective agonist of the serotonin 5-HT1F receptor used for acute migraine. Unlike triptans (5-HT1B/1D), it lacks vasoconstrictor activity, providing antimigraine efficacy through trigeminovascular nociceptive inhibition without coronary vasoconstriction. Formula C19H18F3N3O2, MW 377.4. Research-grade with COA.

5-HT1F AgonistMigraineSerotoninLasmiditanLY-573144CGRPNeurovascularAntimigraine
Request a Quote Technical Specs
377.4
MW (C19H18F3N3O2)
≥98%
Purity (HPLC)
5-HT1F
Selective agonist

Molecular Information

Name: Lasmiditan (LY-573144)
CAS: 439239-90-4
Formula: C19H18F3N3O2
MW: 377.4 g/mol
Class: 5-HT1F receptor agonist
Core: Trifluorophenyl benzamide piperidine
Target: Serotonin 5-HT1F receptor
Activity: Trigeminovascular inhibition
MP: Not firmly reported
Appearance: White to off-white powder
Synonyms: LY-573144
Storage: -20°C, protect from light
439239-90-4
🧪
CAS Number
377.4
⚖️
Molecular Weight
5-HT1F Agonist
🎯
Primary Activity
≥98%
✅
Purity

Product Technical Specifications

Complete physicochemical properties and QC parameters for Lasmiditan (CAS 439239-90-4)

📋 Physicochemical Properties

  • Product NameLasmiditan (LY-573144)
  • IUPAC Name2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridinyl]benzamide
  • CAS Number439239-90-4
  • SynonymsLasmiditan; LY-573144
  • Molecular FormulaC19H18F3N3O2
  • Molecular Weight377.4 g/mol
  • SourceSynthetic serotonergic agent
  • AppearanceWhite to off-white powder
  • Water SolubilityLow
  • Organic SolubilityDMSO; ethanol
  • Compound Class5-HT1F receptor agonist / antimigraine
  • HS Code2934.99

🔬 Quality Control & Handling

  • Purity (HPLC)≥98%
  • FormCrystalline powder
  • Primary TargetSerotonin 5-HT1F receptor
  • Assay ReadoutCGRP / trigeminovascular readouts
  • Selectivity5-HT1F vs 5-HT1B/1D (non-vasoconstrictor)
  • Storage Condition-20°C, sealed, protect from light
  • Solution StabilityDMSO stock stable weeks at -20°C
  • ShippingRoom temp / cold chain
  • QC DocumentationCOA / HPLC / NMR / MS / MSDS
  • Pack Sizes100mg / 500mg / 1g / 5g / 10g
  • Stock StatusIn Stock
  • Use StatementResearch use only; not for human/clinical use

Key Molecular Targets & Pathway Nodes

Lasmiditan engages the molecular machinery and pathway nodes that define its research utility.

🧬 5-HT1F receptor 🧬 Trigeminovascular system 🧬 CGRP pathway 🧬 Pain / nociception 🧭 Migraine circuits 🧪 Serotonin receptors 🔬 Receptor profiling 🦴 Neurovascular 💧 Non-vasoconstrictor 🧭 Headache models

How Lasmiditan Works: Quieting the Migraine Circuit

Lasmiditan selectively activates 5-HT1F, inhibiting CGRP release without vasoconstriction

1

Selective 5-HT1F Receptor Activation

Lasmiditan binds the serotonin 5-HT1F receptor with high selectivity, engaging trigeminovascular neurons involved in migraine pathogenesis.

2

Inhibition of CGRP Release & Nociception

Activation suppresses calcitonin gene-related peptide (CGRP) release and trigeminal nociceptive signaling, dampening the pain-generating cascade.

3

Antimigraine Relief Without Vasoconstriction

Because it spares 5-HT1B/1D-mediated vascular contraction, lasmiditan provides migraine relief without the coronary vasoconstrictor liability of triptans.

⚖️ Lasmiditan vs Comparators

  • Lasmiditan (this product)Selective 5-HT1F agonist; non-vasoconstrictor
  • Triptans (sumatriptan)5-HT1B/1D; vasoconstrictors
  • CGRP antibodiesPeripheral CGRP blockade
  • Selective EdgeNo coronary vasoconstriction
  • Research NicheMigraine & serotonergic pain

♻️ Downstream Biological Consequences

  • Receptor5-HT1F engaged
  • NeuropeptideCGRP release reduced
  • NociceptionTrigeminal pain dampened
  • VasculatureNo constriction (safety)
  • PainMigraine relief readouts
  • ModelsTrigeminovascular assays

Research Applications & Models

Lasmiditan is the reference selective 5-HT1F agent for migraine and serotonergic research.

🧭

Migraine Research

The benchmark selective 5-HT1F antimigraine agent for acute-attack models.

Migraine
🧬

Serotonin Receptor Profiling

Probes 5-HT1F selectivity versus other 5-HT subtypes.

5-HT
🧪

CGRP & Pain Models

Studies CGRP release and trigeminovascular nociception.

CGRP
🦴

Neurovascular Studies

Investigates cephalic vs peripheral vascular pain mechanisms.

Neurovascular
🔬

Drug-Discovery Screening

Serotonergic and antimigraine lead optimization.

Screening
🧬

Receptor Assay Development

Radioligand binding and functional 5-HT1F assays.

Assays

Key Literature & Landmark Publications

Landmark work on 5-HT1F agonists and migraine therapeutics.

Goldstein J, et al. Lasmiditan for acute migraine: phase 3 efficacy and safety. (clinical migraine).
Landmark reference
Saxena PR, et al. 5-HT1F receptors and antimigraine pharmacology. (receptor biology).
Landmark reference
Investigator reports. Lasmiditan receptor selectivity and CGRP modulation.
Landmark reference
Review. Non-vasoconstrictor antimigraine agents.
Landmark reference
LY-573144 development literature. Structure-activity and PK.
Landmark reference

Available Sizes & Ordering

Research-grade Lasmiditan (CAS 439239-90-4) with full QC documentation; standard packs and bulk custom quantities supported.

TierPack SizeStock StatusSuitable ForLead Time
Standard100mgIn StockReceptor / pain assaysSame/next-day ship
Medium500mgIn StockCell & binding studiesSame/next-day ship
Large1gIn StockIn vivo migraine modelsSame/next-day ship
Bulk5gIn StockScreening & formulationQuote to confirm
Industrial10g+Made to orderProcess developmentBatch delivery

💡 Reference sizes shown above; for exact pricing and availability please contact us for a quote. Bulk orders qualify for tiered discounts.

Frequently Asked Questions (FAQ)

What is lasmiditan and what receptor does it target?
Lasmiditan (CAS 439239-90-4), formerly LY-573144, is a highly selective agonist of the serotonin 5-HT1F receptor used for acute migraine. Formula C19H18F3N3O2, MW 377.4.
How is lasmiditan different from triptans?
Triptans act on 5-HT1B/1D and cause vasoconstriction; lasmiditan is selective for 5-HT1F and lacks vasoconstrictor activity, avoiding coronary vascular liability.
What migraine mechanism does it use?
It inhibits calcitonin gene-related peptide (CGRP) release and trigeminovascular nociceptive signaling, quieting the migraine pain pathway.
What readouts confirm activity?
5-HT1F receptor binding/activation assays, CGRP-release measurements, and trigeminovascular / behavioral pain models.
How soluble is lasmiditan and how should it be prepared?
It is soluble in DMSO and ethanol; poorly in water. Prepare a DMSO stock, dilute into medium (final DMSO ≤0.1% v/v), and store at -20°C protected from light.
Is QC documentation provided?
Every batch ships with a Certificate of Analysis (COA) including HPLC purity, NMR structural confirmation and MS data; MSDS/SDS and Certificates of Origin are available on request.

Need Lasmiditan for Your Research?

Research-grade Lasmiditan (CAS 439239-90-4) — purity ≥98% HPLC, COA included
Selective 5-HT1F Agonist — request a quote today

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Weight 1 g

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