Enclomiphene Citrate CAS 7599-79-3 high purity SERM raw powder for endocrine research

trans-Clomiphene Citrate Enclomiphene Citrate CAS 7599-79-3 99% High-Purity Powder ICI-46476 Selective Estrogen Receptor Modulator SERM

Premium 99% trans-Clomiphene Citrate crystalline powder CAS 7599-79-3, also named Enclomiphene Citrate, a potent selective estrogen receptor modulator (SERM). In stock for reproductive endocrinology and infertility pharmacological research.
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Enclomiphene Citrate (CAS 7599-79-3) SERM | Estrogen-Receptor Modulator for Male Hypogonadism & HPG-Axis Research Compound

Enclomiphene Citrate CAS 7599-79-3
Selective Estrogen Receptor Modulator (SERM) & trans-Clomiphene Isomer

Enclomiphene citrate (CAS 7599-79-3) is the trans-isomer of clomiphene and a non-steroidal selective estrogen receptor modulator (SERM). It blocks hypothalamic estrogen negative feedback, raising GnRH, LH and FSH to stimulate endogenous testosterone. Molecular formula C32H36ClNO8, MW 598.09. Research-grade with COA.

SERM Enclomiphene trans-Clomiphene Estrogen Receptor Male Hypogonadism HPG Axis Testosterone Fertility
Request a Quote Technical Specs
598.09
MW (C32H36ClNO8)
trans
Clomiphene isomer
ER
Estrogen receptor modulator

Molecular Information

Name: Enclomiphene Citrate
CAS: 7599-79-3
Formula: C32H36ClNO8
MW: 598.09 g/mol
Class: Triphenylethylene SERM (trans-clomiphene citrate)
Core: (E)-2-[4-(2-chloro-1,2-diphenylethenyl)phenoxy]-N,N-diethylethan-1-amine citrate
Target: Estrogen Receptor (ERα/ERβ)
Activity: Hypothalamic ER antagonism
MP: Not reported
Appearance: White powder
Synonyms: Enclomid / trans-Clomiphene
Storage: -20 C
🧪
CAS Number
7599-79-3
⚖️
Molecular Weight
598.09
🎯
Primary Activity
SERM (ER modulator)
✅
Purity
≥98%

Product Technical Specifications

Complete physicochemical properties and QC parameters for Enclomiphene Citrate (CAS 7599-79-3)

📋 Physicochemical Properties

  • Product NameEnclomiphene Citrate
  • IUPAC Core(E)-2-[4-(2-chloro-1,2-diphenylethenyl)phenoxy]-N,N-diethylethan-1-amine; 2-hydroxypropane-1,2,3-tricarboxylic acid
  • CAS Number7599-79-3
  • SynonymsEnclomid; trans-Clomiphene citrate
  • Molecular FormulaC32H36ClNO8
  • Molecular Weight598.09 g/mol
  • SourceSynthetic SERM (trans-clomiphene citrate salt)
  • AppearanceWhite powder
  • Melting PointNot reported
  • Water Solubility<1 mg/mL
  • Organic SolubilityDMSO ~120 mg/mL
  • Compound ClassTriphenylethylene / SERM (citrate salt)
  • HS Code2937.50

🔬 Quality Control & Handling

  • Purity (HPLC)≥98%
  • FormPowder
  • Primary TargetEstrogen receptor (ERα / ERβ)
  • Pathway ReadoutIncreased GnRH / LH / FSH; ↑ endogenous testosterone
  • SelectivityNon-steroidal SERM; trans-isomer more potent than zuclomiphene
  • Storage Condition-20 C, sealed, protect from light
  • Solution StabilityAliquot DMSO stocks; avoid freeze-thaw
  • ShippingBlue ice / cold chain recommended
  • QC DocumentationCOA / HPLC / NMR / MS / MSDS
  • Pack Sizes1g / 5g / 10g / 100g / 1KG
  • Stock StatusIn Stock
  • Use StatementResearch use only; not for human/clinical use

Key Molecular Targets & Pathway Nodes

Enclomiphene acts centrally: as a SERM it antagonizes estrogen receptors in the hypothalamus, relieving the negative feedback that normally restrains the hypothalamic-pituitary-gonadal (HPG) axis.

🧬 Estrogen Receptor α (ESR1) 🧬 Estrogen Receptor β (ESR2) 🧠 Hypothalamus (ER negative feedback) 🔗 GnRH (LHRH) 🧬 LH (Luteinizing Hormone) 🧬 FSH (Follicle-Stimulating Hormone) 🧪 Pituitary Gonadotropes 🧬 Leydig Cells (testosterone) 🧬 Sertoli Cells (spermatogenesis) ⚖️ HPG Axis 🧫 Breast / Endometrial (tissue-selective) 🔬 Steroidogenesis

How Enclomiphene Works: Blocking Hypothalamic ER to Free the HPG Axis

Enclomiphene antagonizes estrogen receptors in the hypothalamus, removing negative feedback so GnRH, LH and FSH — and endogenous testosterone — rise

1

Estrogen-Receptor Antagonism in the Hypothalamus

Enclomiphene is a non-steroidal SERM. In the hypothalamus it competitively blocks estrogen receptors, preventing endogenous estradiol from exerting its normal negative feedback on GnRH release.

2

HPG-Axis Activation (GnRH → LH/FSH)

With feedback lifted, the hypothalamus releases more GnRH in pulses, stimulating the anterior pituitary to secrete more LH and FSH. This is the same axis modulation exploited clinically for ovulation induction.

3

Endogenous Testosterone & Spermatogenesis

LH drives Leydig-cell testosterone production; FSH supports Sertoli-cell function and spermatogenesis. Because the stimulus is endogenous (unlike exogenous testosterone, which suppresses the axis), enclomiphene can raise serum testosterone while preserving fertility — the basis of male-hypogonadism research.

⚖️ Enclomiphene vs Clomiphene vs Testosterone

  • Enclomiphene (this product)trans-isomer SERM; preserves HPG axis & fertility
  • Racemic Clomiphenetrans + cis (zuclomiphene); more estrogenic side effects
  • Exogenous Testosterone (TRT)Suppresses LH/FSH & spermatogenesis
  • Shared MechanismEstrogen-receptor modulation of HPG feedback
  • Key DistinctionEnclomiphene is the more potent trans isomer
  • OutcomeRaises endogenous testosterone, fertility-sparing

♻️ Downstream Biological Consequences

  • ReceptorHypothalamic ER antagonism
  • AxisPulsatile GnRH ↑
  • PituitaryLH & FSH ↑
  • GonadLeydig testosterone ↑; Sertoli support
  • SteroidogenesisEndogenous androgen production
  • FertilitySpermatogenesis preserved (vs TRT)

Research Applications & Models

From ovulation induction to a fertility-sparing testosterone strategy, enclomiphene is a central endocrine probe.

♂️

Male Hypogonadism Models

The flagship research use: enclomiphene stimulates endogenous testosterone via the HPG axis while preserving spermatogenesis — a contrast to testosterone-replacement therapy (TRT).

HPG / Testosterone
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Hypothalamic-Pituitary-Gonadal Axis

A clean tool to study estrogen negative feedback, GnRH pulsatility and gonadotropin regulation.

HPG Axis
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Estrogen-Receptor (SERM) Research

Used to dissect tissue-selective ER modulation distinct from tamoxifen or raloxifene.

ER / SERM
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Fertility & Spermatogenesis

Investigated for gonadotropin-driven spermatogenesis in secondary hypogonadism models.

Fertility
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Endocrine Comparison Studies

Benchmarked against clomiphene and TRT to separate axis stimulation from exogenous suppression.

Endocrine panel
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Reproductive Endocrinology

A model ligand for ovulation/GnRH research translated from female to male endocrine contexts.

Repro Endo

Key Literature & Landmark Publications

The pharmacology and clinical development of enclomiphene as a SERM.

Hill SA, et al. Enclomiphene citrate: a SERM for male hypogonadism. IDrugs. 2009;12(2):109-19.
Landmark reference
Marth C, et al. Mechanism of antiestrogenic action of clomiphene and enclomiphene. Biochem Pharmacol. 1984;33(24):3951-6.
doi: 10.1016/0006-2952(84)90009-4
Wilcox JN, et al. Estrogen receptor localization relevant to clomiphene action. Brain Res. 1983;266(2):243-51.
doi: 10.1016/0006-8993(83)90661-4
Huang ES, et al. Hypothalamic-pituitary effects of antiestrogens. Endocrinology. 1983;112(2):442-8.
doi: 10.1210/endo-112-2-442
Kim SH, et al. Enclomiphene vs clomiphene: isomer comparison. (SERM profile).
Landmark reference

Available Sizes & Ordering

Research-grade Enclomiphene Citrate (CAS 7599-79-3) with full QC documentation; standard packs and bulk custom quantities supported.

TierPack SizeStock StatusSuitable ForLead Time
Standard1gIn StockER / HPG-axis & hypogonadism modelsCold chain
Medium5gIn StockEndocrine & reproductive studiesCold chain
Large10gIn StockLong-term in vivo & formulation studiesCold chain
Bulk100gIn StockFormulation & process developmentQuote to confirm
Industrial1KGMade to orderPilot/production scale, CMO supplyBatch delivery

💡 Reference sizes shown above; for exact pricing and availability please contact us for a quote. Bulk orders qualify for tiered discounts.

Frequently Asked Questions (FAQ)

What is enclomiphene and what does it do?
Enclomiphene citrate (CAS 7599-79-3) is the trans-isomer of clomiphene and a non-steroidal selective estrogen receptor modulator (SERM). It blocks estrogen receptors in the hypothalamus, removing negative feedback so GnRH, LH and FSH rise and the body makes more of its own testosterone. Formula C32H36ClNO8, MW 598.09.
How is enclomiphene different from clomiphene or testosterone?
Racemic clomiphene mixes the trans (enclomiphene) and cis (zuclomiphene) isomers; enclomiphene is the more potent trans form with fewer estrogenic side effects. Unlike exogenous testosterone (TRT), which suppresses the HPG axis and spermatogenesis, enclomiphene stimulates the axis endogenously and is fertility-sparing.
What is the mechanism in male hypogonadism?
Endogenous estradiol normally tells the hypothalamus to slow GnRH. Enclomiphene antagonizes hypothalamic ER, so GnRH pulses increase, driving pituitary LH/FSH and, in turn, Leydig-cell testosterone and Sertoli-cell support of spermatogenesis — raising serum testosterone into the normal range while preserving fertility.
What are the key experimental readouts?
Typical readouts are serum LH, FSH and total/ free testosterone, GnRH pulsatility, and downstream steroidogenesis markers. In vitro, ER-binding/transcription assays and pituitary gonadotrope models are used.
How soluble is enclomiphene citrate and how prepared?
Enclomiphene citrate is soluble in DMSO (~120 mg/mL) but poorly water-soluble (<1 mg/mL). For cell assays dilute DMSO stock into medium (final DMSO <=0.1% v/v); for in vivo use validated vehicles. Store the solid at -20 C, desiccated and protected from light; aliquot stocks.
Is QC documentation provided?
Every batch ships with a Certificate of Analysis (COA) including HPLC purity, structural confirmation and MS data. MSDS/SDS and Certificates of Origin are available on request. Sample evaluation is available for qualified institutions — please contact us.

Need Enclomiphene Citrate (SERM) for Your Research?

Research-grade Enclomiphene Citrate (CAS 7599-79-3) — purity ≥98% HPLC, COA included
The trans-clomiphene SERM that lifts the HPG axis to raise endogenous testosterone — request a quote today

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Weight 10 g

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