Nutrabiotech RU58841 98% 10G Powder, high purity RU58841 research powder, non-steroidal topical anti-androgen, local androgen receptor blocker, DHT inhibitor for androgenetic alopecia hair loss research

RU-58841 CAS 154992-24-2 99% High-Purity Powder Non-Steroidal Anti-Androgen Androgen Receptor Antagonist Hair Regrowth Anti-Hair Loss Research Reagent

Premium 99% RU-58841 crystalline powder CAS 154992-24-2, selective non-steroidal anti-androgen and potent DHT blocker. Ideal for androgenetic alopecia anti-hair loss and hair regrowth research.
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RU58841 (CAS 154992-24-2) Androgen Receptor Antagonist | Topical Non-Steroidal Antiandrogen for Androgenetic Alopecia & Acne Research

RU58841 CAS 154992-24-2
Topical Non-Steroidal Antiandrogen (NSAA) — Androgen-Receptor Antagonist

RU58841 (CAS 154992-24-2) is a non-steroidal antiandrogen (aryldantoin class) and competitive androgen-receptor (AR) antagonist (IC50 ~100 nM) that blocks DHT binding in scalp tissue with minimal systemic hormonal alteration. Molecular formula C17H18F3N3O3, MW 369.34. Research-grade with COA.

Antiandrogen RU58841 Androgen Receptor DHT Blocker Androgenetic Alopecia Topical Hair Loss Acne
Request a Quote Technical Specs
369.34
MW (C17H18F3N3O3)
~100 nM
AR IC50
Topical
Minimal systemic AR effect

Molecular Information

Name: RU58841
CAS: 154992-24-2
Formula: C17H18F3N3O3
MW: 369.34 g/mol
Class: Aryldantoin non-steroidal antiandrogen
Core: 4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile
Target: Androgen Receptor (AR)
IC50: ~100 nM (AR)
Appearance: White to off-white powder
Synonyms: RU-58841
Storage: 4 C desiccated / -20 C
🧪
CAS Number
154992-24-2
⚖️
Molecular Weight
369.34
🎯
Primary Activity
AR Antagonist
✅
Purity
≥98%

Product Technical Specifications

Complete physicochemical properties and QC parameters for RU58841 (CAS 154992-24-2)

📋 Physicochemical Properties

  • Product NameRU58841
  • IUPAC Core4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile
  • CAS Number154992-24-2
  • SynonymsRU-58841; RU58841
  • Molecular FormulaC17H18F3N3O3
  • Molecular Weight369.34 g/mol
  • SourceSynthetic small molecule (Roussel Uclaf)
  • AppearanceWhite to off-white powder
  • Melting PointNot reported
  • Water SolubilityLow
  • Organic SolubilityDMSO up to ~22 mM; ethanol
  • Compound ClassAryldantoin / non-steroidal antiandrogen
  • HS Code2934.99

🔬 Quality Control & Handling

  • Purity (HPLC)≥98%
  • FormSolid powder
  • Primary TargetAndrogen receptor (AR / NR3C4)
  • Pathway ReadoutReduced AR nuclear translocation; blocked DHT-driven transcription
  • SelectivityNon-steroidal; topical; minimal systemic DHT alteration
  • Storage Condition4 C desiccated / -20 C, sealed, protect from light
  • Solution StabilityAliquot DMSO stocks; avoid freeze-thaw
  • ShippingRoom temp / blue ice
  • QC DocumentationCOA / HPLC / NMR / MS / MSDS
  • Pack Sizes1g / 5g / 10g / 100g / 1KG
  • Stock StatusIn Stock
  • Use StatementResearch use only; not for human/clinical use

Key Molecular Targets & Pathway Nodes

RU58841's sole molecular node is the androgen receptor; its value is the combination of potent AR blockade with a topical, locally confined metabolic profile.

🧬 Androgen Receptor (AR) 🔗 Dihydrotestosterone (DHT) 🔗 Testosterone 🧱 AR Nuclear Translocation 🧱 Androgen-Response Elements 🧱 Sebaceous Gland 🧱 Hair Follicle (dermal papilla) 🧱 Scalp Keratinocytes ⚡ 5α-Reductase axis (indirect) 🧪 Acne / Sebum Models 🧬 Androgen-Dependent Tissue 🔬 Topical Delivery / PK

How RU58841 Works: Local Androgen-Receptor Blockade at the Follicle

RU58841 competitively binds the androgen receptor in scalp tissue, displacing DHT and halting the miniaturization signal — without systemic hormone disruption

1

Competitive AR Binding at the Follicle

RU58841 is a non-steroidal antiandrogen that competitively binds the androgen receptor (IC50 ~100 nM; Ka ~1.1 nM), blocking endogenous androgens — especially dihydrotestosterone (DHT) — from engaging AR in scalp and skin.

2

Blocked AR Translocation & Transcription

With AR occupation prevented, DHT cannot drive receptor nuclear translocation or androgen-response-element transcription. In hair follicles this halts the DHT-driven miniaturization (catagen promotion) program.

3

Topical Confinement — Minimal Systemic Effect

Topically, RU58841 is metabolized locally with minimal conversion to active systemic metabolites and does not meaningfully alter serum DHT. This local-only profile distinguishes it from oral antiandrogens that suppress hormones body-wide.

⚖️ RU58841 vs Finasteride vs Flutamide

  • RU58841 (this product)Topical AR antagonist; local, minimal systemic DHT change
  • Finasteride5α-reductase inhibitor; lowers serum DHT systemically
  • Flutamide / BicalutamideOral AR antagonists; systemic hormonal effects
  • Shared TargetAndrogen signaling (AR or DHT synthesis)
  • Key DistinctionRU58841 is topical & locally confined
  • EvidenceHair regrowth in stumptailed macaque xenografts

♻️ Downstream Biological Consequences

  • ReceptorAR occupation blocked (competitive)
  • DownstreamAR nuclear translocation ↓
  • TranscriptionAndrogen-response genes ↓
  • FollicleReduced miniaturization; prolonged anagen
  • SebumSebaceous activity ↓ (acne models)
  • SystemicSerum DHT largely unchanged (topical)

Research Applications & Models

A cornerstone topical antiandrogen for hair and skin research, prized for local action without systemic endocrine disruption.

💇

Androgenetic Alopecia (AGA) Models

The primary research use: RU58841 blocks scalp AR to halt follicle miniaturization and promote regrowth in human scalp xenografts and macaque models.

AR / Follicle
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Topical Antiandrogen Delivery

A model for locally confined AR antagonism versus systemic oral antiandrogens; studied for follicle-targeted delivery vehicles.

Topical PK
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Acne & Seborrhea Models

Reduces sebaceous-gland activity via AR blockade; studied in acne and sebum-regulation models.

Sebum / Acne
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Androgen-Receptor Research

A fiducial competitive AR antagonist for binding, translocation and transcription-reporter assays.

AR / NR3C4
⚖️

Antiandrogen Comparison

Benchmarked against finasteride and flutamide to separate receptor blockade from DHT synthesis.

AR panel
🧬

Hair-Cycle Biology

Used to probe anagen/catagen regulation by androgens in dermal papilla.

Hair cycle

Key Literature & Landmark Publications

The antiandrogen pharmacology and hair/ acne research using RU58841.

Pan H, et al. Evaluation of RU58841 as an anti-androgen in prostate PC3 cells and a topical anti-alopecia agent in the bald scalp of stumptailed macaques. Endocrine. 1998;9(1):39-43.
doi: 10.1385/ENDO:9:1:39
Obana N, et al. Inhibition of hair growth by testosterone in the presence of dermal papilla cells from the frontal bald scalp of the postpubertal stumptailed macaque. Endocrinology. 1997;138(1):356-61.
doi: 10.1210/endo.138.1.4522
Supplier profile: RU58841, non-steroidal antiandrogen, IC50 100 nM, Ka 1.1 nM; >100% hair-follicle increase in human scalp xenografts.
Landmark reference
Roussel Uclaf arylantoin antiandrogen program (Phase 2 acne/AGA, discontinued).
Landmark reference
Comparative antiandrogen review: topical vs systemic AR blockade.
Landmark reference

Available Sizes & Ordering

Research-grade RU58841 (CAS 154992-24-2) with full QC documentation; standard packs and bulk custom quantities supported.

TierPack SizeStock StatusSuitable ForLead Time
Standard1gIn StockAR binding & topical AGA assaysSame/next-day ship
Medium5gIn StockFollicle, sebaceous & acne modelsSame/next-day ship
Large10gIn StockLong-term in vivo & formulation studiesSame/next-day ship
Bulk100gIn StockFormulation & process developmentQuote to confirm
Industrial1KGMade to orderPilot/production scale, CMO supplyBatch delivery

💡 Reference sizes shown above; for exact pricing and availability please contact us for a quote. Bulk orders qualify for tiered discounts.

Frequently Asked Questions (FAQ)

What is RU58841 and what does it do?
RU58841 (CAS 154992-24-2) is a non-steroidal antiandrogen (arylantoin class) and a competitive antagonist of the androgen receptor (AR), with IC50 ~100 nM (Ka ~1.1 nM). It blocks dihydrotestosterone (DHT) from binding AR in scalp and skin. Formula C17H18F3N3O3, MW 369.34.
How is RU58841 different from finasteride?
Finasteride is a 5α-reductase inhibitor that lowers serum DHT systemically. RU58841 is a topical AR antagonist that blocks the receptor locally in the follicle and does not meaningfully change serum DHT. This local-only profile avoids the body-wide hormonal effects of oral antiandrogens.
What is the mechanism in androgenetic alopecia?
DHT binds scalp AR and drives follicle miniaturization (premature catagen). RU58841 competitively occupies AR, preventing DHT-driven nuclear translocation and androgen-response transcription, so the follicle stays larger and longer in anagen. Studies in stumptailed macaques and human scalp xenografts showed marked hair regrowth.
What are the key experimental readouts?
Readouts include AR-binding/translocation assays, androgen-response-reporter (luciferase) activity, sebaceous-gland regression in hamster-ear models, and hair-follicle counts in xenograft/macaque studies.
How soluble is RU58841 and how should it be prepared?
RU58841 is soluble in DMSO (up to ~22 mM) and ethanol. For topical/receptor studies dilute DMSO stock into suitable vehicles (final DMSO <=0.1% v/v for cell assays). Store the solid desiccated at 4 C or -20 C, protected from light; aliquot stocks to avoid freeze-thaw.
Is QC documentation provided?
Every batch ships with a Certificate of Analysis (COA) including HPLC purity, NMR structural confirmation and MS data. MSDS/SDS and Certificates of Origin are available on request. Sample evaluation is available for qualified institutions — please contact us.

Need RU58841 (Androgen Receptor Antagonist) for Your Research?

Research-grade RU58841 (CAS 154992-24-2) — purity ≥98% HPLC, COA included
The topical, locally confined AR/DHT antagonist for androgenetic alopecia and acne research — request a quote today

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