Kopexil CAS 74638-76-9 98% Purity Anti Hair Loss Powder

Kopexil CAS 74638-76-9 98% Purity Diaminopyrimidine Oxide Anti Hair Loss Powder

High purity Kopexil powder CAS 74638-76-9 with 98% HPLC purity. Also known as Diaminopyrimidine Oxide and Aminexil, premium anti-hair loss and hair growth cosmetic raw material, factory bulk supply with full certificates.
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Kopexil (Aminexil) CAS 74638-76-9 | Anti-Hair Loss Active & 5α-Reductase Inhibitor | Nutrabiotech Chem

Kopexil (Aminexil) CAS 74638-76-9
Anti-Hair Loss Active & 5α-Reductase Inhibitor

Kopexil (CAS 74638-76-9), also known as Aminexil, is a minoxidil-like anti-hair-loss active ingredient. It inhibits 5α-reductase, acts as an anti-fibrotic agent that softens perifollicular collagen, and prolongs the anagen (growth) phase of the hair cycle to reduce shedding and improve hair anchoring. Formula C4H6N4O, MW 126.12. Cosmetic & research grade with COA.

KopexilAminexil5α-ReductaseHair LossAnagenAnti-FibroticAndrogenetic AlopeciaCosmetic Active
Request a Quote Technical Specs
126.12
MW (C4H6N4O)
≥98%
Purity (HPLC)
5α-R
Reductase target

Molecular Information

Name: Kopexil (Aminexil)
CAS: 74638-76-9
Formula: C4H6N4O
MW: 126.12 g/mol
Class: Pyrimidine anti-hair-loss derivative
Core: 2,4-Diaminopyrimidine 3-oxide
Target: 5α-reductase / follicular anchoring
Activity: Anagen prolongation, anti-fibrotic
MP: Not firmly reported
Appearance: White to off-white powder
Synonyms: Aminexil; Mexoryl SAG
Storage: -20°C, dry, protect from light
74638-76-9
🧪
CAS Number
126.12
⚖️
Molecular Weight
5α-Reductase
🎯
Primary Activity
≥98%
✅
Purity

Product Technical Specifications

Complete physicochemical properties and QC parameters for Kopexil (Aminexil, CAS 74638-76-9)

📋 Physicochemical Properties

  • Product NameKopexil (Aminexil)
  • IUPAC Name2,4-diaminopyrimidine 3-oxide
  • CAS Number74638-76-9
  • SynonymsAminexil; Mexoryl SAG; Diaminopyrimidine oxide
  • Molecular FormulaC4H6N4O
  • Molecular Weight126.12 g/mol
  • SourceSynthetic (cosmetic active)
  • AppearanceWhite to off-white powder
  • Water SolubilityModerate (hydroglycolic-friendly)
  • Organic SolubilityDMSO (~5 mg/mL); ethanol
  • Boiling Point~475.5 °C (predicted)
  • Density~1.69 g/cm³ (predicted)
  • Compound ClassAnti-hair-loss pyrimidine derivative
  • HS Code2933.59

🔬 Quality Control & Handling

  • Purity (HPLC)≥98%
  • FormPowder (cosmetic / research grade)
  • Primary Target5α-reductase; follicular collagen
  • Assay ReadoutHair cycle / anchoring readouts
  • SelectivityNon-hormonal anti-fibrotic (follicle)
  • Storage Condition-20°C, sealed, dry, protect from light
  • Solution StabilityDMSO stock stable at -20°C
  • ShippingRoom temp / cold chain
  • QC DocumentationCOA / HPLC / NMR / MSDS
  • Pack Sizes100g / 500g / 1kg / 5kg
  • Stock StatusIn Stock
  • Use StatementCosmetic / research use only; not for human clinical use

Key Molecular Targets & Biology Nodes

Kopexil engages the follicular and enzymatic machinery that defines its anti-hair-loss utility.

🧬 5α-Reductase 🧬 Androgen (DHT) pathway 🧬 Potassium channels 💧 Perifollicular collagen 🧭 Anagen phase 🍃 Hair follicle 🔬 Scalp microcirculation ♻️ Anti-fibrotic 🦲 Androgenetic alopecia 🧴 Cosmetic active

How Kopexil Works: Protecting the Follicle & Prolonging Growth

Kopexil targets the collagen sheath and androgen metabolism around the follicle to keep hairs anchored and growing.

1

Inhibition of 5α-Reductase & Fibrosis

Kopexil inhibits 5α-reductase and acts as an anti-fibrotic agent (limiting lysyl-hydroxylase driven collagen hardening) around the follicle, preserving a soft anchoring environment.

2

Prolongation of the Anagen Phase

By improving the perifollicular environment and microcirculation, Kopexil prolongs the anagen (growth) phase and delays transition into the resting (telogen) phase.

3

Reduced Shedding & Better Anchoring

In research and cosmetic use, Kopexil reduces premature hair-root loss, supports hair anchoring and contributes to visible hair density over time.

⚖️ Kopexil vs Comparators

  • Kopexil (this product)5α-reductase / anti-fibrotic (follicle)
  • MinoxidilK⁺-channel vasodilator (growth phase)
  • FinasterideOral 5α-reductase (type II) inhibitor
  • Selective EdgeNon-hormonal, mild, water-friendly
  • Research NicheTopical anti-hair-loss actives

♻️ Downstream Biological Consequences

  • Enzyme5α-reductase down
  • MatrixPerifollicular collagen softened
  • CycleAnagen prolonged
  • AnchoringRoot loss reduced
  • ScalpMicrocirculation improved
  • ModelsHair-cycle / trichology studies

Research & Formulation Applications

Kopexil is a staple topical anti-hair-loss active for cosmetic, trichology and follicular research.

🦲

Anti-Hair Loss Formulations

Core active in leave-on scalp serums, ampoules and lotions for thinning and shedding.

Hair Loss
🌱

Hair Growth Support

Prolongs anagen and supports anchoring in androgenetic alopecia research.

Growth
🧪

Combination Therapies

Paired with minoxidil or niacinamide in multi-active scalp regimens.

Combo
🧬

5α-Reductase Studies

Benchmarks reductase inhibition and follicular SAR.

5α-R
🏥

Cosmetic Trichology

Dermocosmetic and salon treatment development.

Trichology
🔬

Follicular Biology Research

Models of collagen sheath / anchoring and hair-cycle dynamics.

Research

Key Literature & Landmark Publications

Landmark and representative work on aminexil / diaminopyrimidine oxide, 5α-reductase and hair-cycle biology.

Clinical & preclinical studies. Aminexil (diaminopyrimidine oxide) in androgenetic alopecia and hair anchoring.
Landmark reference
Review. 5α-reductase inhibitors and the hair growth cycle.
Landmark reference
Dermocosmetic reports. Topical anti-fibrotic actives and perifollicular collagen.
Landmark reference
Formulation science. Aminexil / minoxidil combination scalp delivery.
Landmark reference
Trichology literature. Hair-cycle (anagen/telogen) modulation by topical actives.
Landmark reference

Available Sizes & Ordering

Research / cosmetic-grade Kopexil (CAS 74638-76-9) with full QC documentation; standard packs and bulk custom quantities supported.

TierPack SizeStock StatusSuitable ForLead Time
Standard100 gIn StockLab / formula samplingSame/next-day ship
Medium500 gIn StockPilot formulationsSame/next-day ship
Large1 kgIn StockProduction batchesSame/next-day ship
Bulk5 kgIn StockIndustrial scaleQuote to confirm
Industrial10 kg+Made to orderProcess developmentBatch delivery

💡 Reference sizes shown above; for exact pricing and availability please contact us for a quote. Bulk orders qualify for tiered discounts.

Frequently Asked Questions (FAQ)

What is Kopexil and what is it used for?
Kopexil (CAS 74638-76-9), also known as Aminexil, is a minoxidil-like anti-hair-loss active used in scalp serums, ampoules and anti-hair-loss formulations. It helps reduce hair shedding and supports hair anchoring by softening perifollicular collagen. Formula C4H6N4O, MW 126.12.
How does Kopexil work on hair loss?
Kopexil inhibits 5α-reductase and acts as an anti-fibrotic agent that prevents hardening of the collagen sheath around the follicle. This prolongs the anagen (growth) phase, improves scalp microcirculation and reduces premature hair root loss.
How is Kopexil different from minoxidil?
Both are used for androgenetic alopecia, but Kopexil is a non-hormonal pyrimidine derivative structurally related to minoxidil yet milder and more water-friendly. It targets follicular collagen/fibrosis rather than primarily vasodilation, and is often paired with minoxidil or niacinamide in formulations.
How soluble is Kopexil and how should it be prepared?
Kopexil dissolves in DMSO (~5 mg/mL, 39.6 mM) and is more water-friendly than the free base of related actives; cosmetic stocks are commonly prepared as aqueous or hydroglycolic solutions. Store powder at -20°C away from moisture and light.
Is Kopexil a hormonal ingredient?
Kopexil is considered a non-hormonal anti-hair-loss ingredient. It is supplied for cosmetic formulation and research use; it is not intended for human or clinical/injectable use.
Is QC documentation provided?
Every batch ships with a Certificate of Analysis (COA) including HPLC purity, structural confirmation and identity data; MSDS/SDS and Certificates of Origin are available on request.

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Research / cosmetic-grade Kopexil (CAS 74638-76-9) — purity ≥98% HPLC, COA included
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