High purity Dutasteride powder CAS 164656-23-9 99% HPLC dual 5α-reductase inhibitor strong DHT blocker for anti hair loss research

Dutasteride CAS 164656-23-9 99% Purity Dual 5α-Reductase Inhibitor Powder

High purity Dutasteride powder CAS 164656-23-9 with 99% HPLC purity. Potent dual 5α-reductase inhibitor, powerful DHT blocker for anti-hair loss and BPH research, factory bulk supply with full certificates.
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Dutasteride CAS 164656-23-9 | Dual 5α-Reductase Inhibitor for Hair Loss & BPH | Nutrabiotech Chem

Dutasteride CAS 164656-23-9
Dual 5α-Reductase Inhibitor (DHT Blocker)

Dutasteride (CAS 164656-23-9) is a synthetic 4-azasteroid that inhibits both type I and type II steroid 5α-reductase isozymes. By blocking conversion of testosterone to dihydrotestosterone (DHT) at both isozymes, it suppresses DHT more completely than selective type II inhibitors, and is a key research compound for androgenetic alopecia and benign prostatic hyperplasia (BPH). Formula C27H30F6N2O2, MW 528.53. Research / pharma grade with COA.

Dutasteride5α-ReductaseDHT BlockerHair LossAndrogenetic AlopeciaBPHAvodartDual Inhibitor
Request a Quote Technical Specs
528.53
MW (C27H30F6N2O2)
≥98%
Purity (HPLC)
I + II
5α-reductase

Molecular Information

Name: Dutasteride
CAS: 164656-23-9
Formula: C27H30F6N2O2
MW: 528.53 g/mol
Class: 4-Azasteroid dual 5α-reductase inhibitor
Core: 4-Aza-5α-androst-1-ene-17β-carboxamide
Target: 5α-reductase (type I & II)
Activity: DHT suppression (broad)
MP: Reported ~242-250 °C
Appearance: White to off-white powder
Synonyms: GG-745; Avodart
Storage: -20°C, protect from light
164656-23-9
🧪
CAS Number
528.53
⚖️
Molecular Weight
Dual 5α-R
🎯
Primary Activity
≥98%
✅
Purity

Product Technical Specifications

Complete physicochemical properties and QC parameters for Dutasteride (CAS 164656-23-9)

📋 Physicochemical Properties

  • Product NameDutasteride
  • IUPAC Name(5α,17β)-N-[2,5-bis(trifluoromethyl)phenyl]-3-oxo-4-azaandrost-1-ene-17-carboxamide
  • CAS Number164656-23-9
  • SynonymsGG-745; Avodart
  • Molecular FormulaC27H30F6N2O2
  • Molecular Weight528.53 g/mol
  • SourceSynthetic 4-azasteroid
  • AppearanceWhite to off-white powder
  • Water SolubilityPractically insoluble
  • Organic SolubilityDMSO; ethanol; methanol; PEG-400
  • Melting Point~242-250 °C
  • Compound ClassDual 5α-reductase inhibitor (anti-androgen)
  • HS Code2937.29

🔬 Quality Control & Handling

  • Purity (HPLC)≥98%
  • FormCrystalline powder
  • Primary Target5α-reductase (type I & II)
  • Assay ReadoutDHT / androgen readouts
  • SelectivityDual type I + II 5α-reductase
  • Storage Condition-20°C, sealed, protect from light
  • Solution StabilityDMSO stock stable at -20°C
  • ShippingRoom temp / cold chain
  • QC DocumentationCOA / HPLC / NMR / MS / MSDS
  • Pack Sizes100mg / 500mg / 1g / 5g / 10g
  • Stock StatusIn Stock
  • Use StatementResearch / formulation use; not for human clinical use

Key Molecular Targets & Pathway Nodes

Dutasteride engages both 5α-reductase isozymes at the core of androgen-driven hair loss and prostatic research.

🧬 5α-Reductase (Type I) 🧬 5α-Reductase (Type II) 🧬 Dihydrotestosterone (DHT) 🧬 Testosterone 🧪 Androgen pathway 💧 Scalp DHT 🧭 Hair follicle 🍃 Prostate (BPH) 🔬 Steroid SAR 🦲 Androgenetic alopecia

How Dutasteride Works: Broad-Spectrum DHT Suppression

Dutasteride blocks both 5α-reductase isozymes, giving more complete DHT lowering than type II-selective agents.

1

Dual Inhibition of 5α-Reductase

Dutasteride inhibits both type I and type II steroid 5α-reductase, the enzymes that convert testosterone into the potent androgen dihydrotestosterone (DHT).

2

Near-Complete DHT Reduction

Because both isozymes are blocked, scalp and serum DHT fall more completely than with type II-selective inhibitors, weakening androgenic signaling throughout target tissues.

3

Follicular & Prostatic Response

Profound DHT lowering reduces hair-follicle miniaturization (alopecia models) and prostatic androgenic stimulation (BPH models), supporting healthier phenotypes.

⚖️ Dutasteride vs Comparators

  • Dutasteride (this product)Dual type I + II 5α-reductase inhibitor
  • FinasterideSelective type II 5α-reductase inhibitor
  • MinoxidilK⁺-channel vasodilator (topical)
  • Selective EdgeBroader, more complete DHT suppression
  • Research NicheHair loss & BPH / androgen studies

♻️ Downstream Biological Consequences

  • Enzyme5α-reductase (I+II) blocked
  • AndrogenDHT markedly reduced
  • FollicleMiniaturization reversed
  • ScalpHair density readouts up
  • ProstateAndrogenic volume down (BPH)
  • ModelsAndrogen / alopecia pharmacology

Research & Formulation Applications

Dutasteride is a high-potency anti-androgen for hair-loss, prostatic and endocrinology research.

🦲

Androgenetic Alopecia Research

High-potency comparator for DHT-driven follicle-miniaturization models.

Hair Loss
🍃

BPH Models

Prostatic androgenic-stimulation and volume studies.

BPH
🧬

Dual 5α-Reductase Profiling

Benchmarks type I + II isozyme inhibition and steroid SAR.

5α-R
🧪

Androgen Pathway Studies

DHT, testosterone and AR-signaling assays.

Androgen
⚖️

Head-to-Head vs Finasteride

Comparative DHT-lowering and efficacy studies.

Comparator
🔬

Endocrinology Research

Steroid-metabolism and anti-androgen pharmacology.

Endo

Key Literature & Landmark Publications

Landmark clinical and preclinical work on dutasteride, dual 5α-reductase inhibition and androgenetic alopecia.

Clark RV, et al. Marked suppression of dihydrotestosterone in men with benign prostatic hyperplasia by dutasteride, a dual 5α-reductase inhibitor. J Clin Endocrinol Metab. 2004;89(5):2179-2184.
Landmark clinical reference
Eun HC, et al. Dutasteride 0.5 mg once daily in male patients with male pattern hair loss: a randomized, double-blind, placebo-controlled, phase III study. J Am Acad Dermatol. 2010;63(5):817-824.
Landmark clinical reference
Review. Dual vs selective 5α-reductase inhibition.
Landmark reference
Preclinical reports. Dutasteride in follicle miniaturization models.
Landmark reference
Comparative studies. Dutasteride vs finasteride in alopecia and BPH.
Landmark reference

Available Sizes & Ordering

Research / pharma-grade Dutasteride (CAS 164656-23-9) with full QC documentation; standard packs and bulk custom quantities supported.

TierPack SizeStock StatusSuitable ForLead Time
Standard100 mgIn StockReceptor / DHT assaysSame/next-day ship
Medium500 mgIn StockCell & binding studiesSame/next-day ship
Large1 gIn StockIn vivo modelsSame/next-day ship
Bulk5 gIn StockScreening & formulationQuote to confirm
Industrial10 g+Made to orderProcess developmentBatch delivery

💡 Reference sizes shown above; for exact pricing and availability please contact us for a quote. Bulk orders qualify for tiered discounts.

Frequently Asked Questions (FAQ)

What is dutasteride and what is it researched for?
Dutasteride (CAS 164656-23-9) is a synthetic 4-azasteroid that inhibits both type I and type II 5α-reductase isozymes, lowering dihydrotestosterone (DHT). It is studied in androgenetic alopecia and benign prostatic hyperplasia (BPH). Formula C27H30F6N2O2, MW 528.53.
How does dutasteride work?
Dutasteride inhibits both 5α-reductase isozymes that convert testosterone into DHT. Because it blocks type I as well as type II, it suppresses DHT more completely than finasteride, relieving follicle miniaturization and prostatic androgenic stimulation.
What is the difference between dutasteride and finasteride?
Dutasteride inhibits both type I and type II 5α-reductase; finasteride is selective for type II. As a result dutasteride produces a greater reduction in DHT and has a longer half-life. Both are studied for hair loss and BPH.
How soluble is dutasteride and how should it be prepared?
Dutasteride is practically insoluble in water but soluble in DMSO, ethanol, methanol, PEG-400 and chloroform. Prepare DMSO or ethanol stocks and store at -20°C protected from light.
Is dutasteride a hormonal compound?
Dutasteride is an anti-androgen acting on the androgen (DHT) pathway, not a hormone itself. It is supplied for research and formulation use; not for human or clinical/injectable use without authorization.
Is QC documentation provided?
Every batch ships with a Certificate of Analysis (COA) including HPLC purity, NMR structural confirmation and MS data; MSDS/SDS and Certificates of Origin are available on request.

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Research / pharma-grade Dutasteride (CAS 164656-23-9) — purity ≥98% HPLC, COA included
Dual (I+II) 5α-reductase inhibitor (DHT blocker) — request a quote today

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