CAS 59865-13-3 Cyclosporin A high purity bulk powder immunosuppressant compound for organ transplant anti-rejection research

Cyclosporin A CAS 59865-13-3 98% Purity Immunosuppressant Powder

High purity Cyclosporin A powder CAS 59865-13-3 with 98% HPLC purity. A potent cyclic polypeptide immunosuppressant for organ transplant and autoimmune disease research, factory bulk supply with full certificates.
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Cyclosporin A CAS 59865-13-3 | Calcineurin Inhibitor & Immunosuppressant | Nutrabiotech Chem

Cyclosporin A CAS 59865-13-3
Calcineurin Inhibitor & Immunosuppressant

Cyclosporin A (CAS 59865-13-3) is a cyclic undecapeptide produced by the fungus Tolypocladium inflatum and one of the most widely used immunosuppressants in research. It binds the intracellular protein cyclophilin and inhibits the phosphatase calcineurin (IC50 ~5 nM), blocking NFAT-driven T-cell activation. Beyond transplant and autoimmune models, it is studied topically in alopecia areata and for antiviral (including coronavirus) activity. Formula C62H111N11O12, MW 1202.6. Research grade with COA.

Cyclosporin ACalcineurinImmunosuppressantNFATAlopecia AreataTransplantCoronavirusCyclic Peptide
Request a Quote Technical Specs
1202.6
MW (C62H111N11O12)
≥98%
Purity (HPLC)
~5 nM
Calcineurin IC50

Molecular Information

Name: Cyclosporin A
CAS: 59865-13-3
Formula: C62H111N11O12
MW: 1202.6 g/mol
Class: Cyclic undecapeptide (immunosuppressant)
Source: Tolypocladium inflatum (fungus)
Target: Calcineurin (via cyclophilin)
Activity: NFAT / T-cell inhibition
MP: ~144-151 °C
Appearance: White to off-white crystalline powder
Synonyms: CsA; Ciclosporin A; Sandimmune
Storage: -20°C, protect from light
59865-13-3
🧪
CAS Number
1202.6
⚖️
Molecular Weight
Calcineurin
🎯
Primary Activity
≥98%
✅
Purity

Product Technical Specifications

Complete physicochemical properties and QC parameters for Cyclosporin A (CAS 59865-13-3)

📋 Physicochemical Properties

  • Product NameCyclosporin A
  • IUPAC NameCyclic undecapeptide (30-ethyl-33-...-undecaazacyclotritriacontane)
  • CAS Number59865-13-3
  • SynonymsCiclosporin A; CsA; Sandimmune; NSC 290193
  • Molecular FormulaC62H111N11O12
  • Molecular Weight1202.6 g/mol
  • SourceFungal metabolite (Tolypocladium inflatum)
  • AppearanceWhite to off-white crystalline powder
  • Water SolubilityPoor (lipophilic peptide)
  • Organic SolubilityDMSO; ethanol; methanol; chloroform
  • Melting Point~144-151 °C
  • Compound ClassCyclic peptide calcineurin inhibitor
  • HS Code2941.90

🔬 Quality Control & Handling

  • Purity (HPLC)≥98%
  • FormCrystalline powder
  • Primary TargetCalcineurin (via cyclophilin)
  • Reported PotencyCalcineurin IC50 ~5 nM
  • Assay ReadoutNFAT / T-cell activation
  • Storage Condition-20°C, sealed, protect from light
  • Solution StabilityDMSO stock stable at -20°C
  • ShippingRoom temp / cold chain
  • QC DocumentationCOA / HPLC / NMR / MS / MSDS
  • Pack Sizes25mg / 100mg / 500mg / 1g / 5g
  • Stock StatusIn Stock
  • Use StatementResearch use only; not for human clinical use

Key Molecular Targets & Pathway Nodes

Cyclosporin A engages the calcineurin/NFAT axis and related nodes central to immunity, follicles and virology.

🧬 Calcineurin 🧬 Cyclophilin 🧬 NFAT 🧪 T-cell activation 💧 Mitochondrial MPTP 🧭 Alopecia areata 🍃 Transplant / immunity 🔬 Autoimmune models 🦠 Coronavirus replication 🧬 IL-2 signaling

How Cyclosporin A Works: Silencing the Calcineurin/NFAT Axis

Cyclosporin A blocks the intracellular signaling switch that turns on T-cell activation and downstream immunity.

1

Complex Formation with Cyclophilin

Cyclosporin A enters cells and binds the abundant cytosolic protein cyclophilin, forming a CsA-cyclophilin complex that is the active species.

2

Inhibition of Calcineurin Phosphatase

The complex binds and inhibits calcineurin, the Ca2+/calmodulin-dependent phosphatase, preventing dephosphorylation of the transcription factor NFAT.

3

Suppression of T-Cell Activation

Without NFAT translocation, IL-2 and other activation genes are not transcribed; T-cell proliferation and adaptive immunity are suppressed, with additional MPTP- and antiviral effects.

⚖️ Cyclosporin A vs Comparators

  • Cyclosporin A (this product)Calcineurin inhibitor (cyclophilin-bound)
  • Tacrolimus (FK506)Calcineurin inhibitor (FKBP-bound)
  • Rapamycin (sirolimus)mTOR inhibitor (downstream)
  • Selective EdgeFoundational NFAT / immunity probe
  • Research NicheImmunology / alopecia / virology

♻️ Downstream Biological Consequences

  • EnzymeCalcineurin inhibited
  • TranscriptionNFAT blocked
  • ImmuneT-cell activation down
  • FollicleLocal immune modulation (alopecia)
  • MitochondriaMPTP opening inhibited
  • ViralCoronavirus replication reduced

Research & Formulation Applications

Cyclosporin A is a foundational immune-signaling probe with uses spanning transplantation, autoimmunity, hair loss and virology.

🤝

Transplant Rejection Models

Benchmark immunosuppression and allograft survival studies.

Transplant
🦲

Alopecia Areata Research

Topical immune modulation at the hair follicle.

Alopecia
🛡️

Autoimmune / Inflammatory

Psoriasis, atopic dermatitis and rheumatoid models.

Autoimmune
🧬

NFAT / Calcineurin Assays

Signal-transduction and reporter-gene profiling.

NFAT
🦠

Antiviral Research

Reported inhibition of coronavirus replication.

Antiviral
🔬

Stem-Cell & Signaling

Calcineurin-dependent differentiation and survival studies.

Signaling

Key Literature & Landmark Publications

Landmark work on cyclosporin A, cyclophilin, calcineurin/NFAT and its research applications.

Handschumacher RE, et al. Cyclophilin: a specific cytosolic binding protein for cyclosporin A. Science. 1984;226(4674):544-547.
Landmark reference
de Wilde AH, et al. Cyclosporin A inhibits the replication of diverse coronaviruses. J Gen Virol. 2011;92(Pt 11):2542-2550.
Antiviral reference
Borel JF, et al. Comparative study of in vitro and in vivo drug effects on cell-mediated cytotoxicity. Immunology. 1976;32(3):395-401.
Discovery reference
Clinical & preclinical reports. Cyclosporin A in alopecia areata (topical) models.
Landmark reference
Review. Calcineurin / NFAT signaling and immunosuppression.
Landmark reference

Available Sizes & Ordering

Research-grade Cyclosporin A (CAS 59865-13-3) with full QC documentation; standard packs and bulk custom quantities supported.

TierPack SizeStock StatusSuitable ForLead Time
Standard25 mgIn StockCalcineurin / NFAT assaysSame/next-day ship
Medium100 mgIn StockCell & signaling studiesSame/next-day ship
Large500 mgIn StockIn vivo modelsSame/next-day ship
Bulk1 gIn StockScreening & formulationQuote to confirm
Industrial5 g+Made to orderProcess developmentBatch delivery

💡 Reference sizes shown above; for exact pricing and availability please contact us for a quote. Bulk orders qualify for tiered discounts.

Frequently Asked Questions (FAQ)

What is cyclosporin A and what is it researched for?
Cyclosporin A (CAS 59865-13-3) is a cyclic peptide from the fungus Tolypocladium inflatum and a potent immunosuppressant. It inhibits calcineurin and is studied in transplant rejection, autoimmune / inflammatory models, alopecia areata (topical) and antiviral (including coronavirus) research. Formula C62H111N11O12, MW 1202.6.
How does cyclosporin A work?
Cyclosporin A binds the intracellular protein cyclophilin; the complex inhibits calcineurin, a phosphatase that normally dephosphorylates the transcription factor NFAT. Blocking NFAT prevents IL-2 transcription and T-cell activation, suppressing adaptive immunity.
Is cyclosporin A used in hair loss research?
Yes. Topical cyclosporin A is investigated in alopecia areata models, where local immune modulation at the follicle can support hair regrowth. It is a distinct mechanism from finasteride / minoxidil and is studied as a complementary or refractory-case approach.
How soluble is cyclosporin A and how should it be prepared?
Cyclosporin A is soluble in DMSO, ethanol, methanol, chloroform and acetone but poorly soluble in water. Prepare DMSO or ethanol stocks and store at -20°C protected from light; keep final vehicle concentration low in cell assays to avoid toxicity.
What else does cyclosporin A inhibit?
Beyond calcineurin/NFAT, cyclosporin A inhibits opening of the mitochondrial permeability transition pore (MPTP) and has reported antiviral activity against several coronaviruses; it also inhibits CYP3A in liver microsomes.
Is QC documentation provided?
Every batch ships with a Certificate of Analysis (COA) including HPLC purity, structural confirmation and MS data; MSDS/SDS and Certificates of Origin are available on request.

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Research-grade Cyclosporin A (CAS 59865-13-3) — purity ≥98% HPLC, COA included
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