Nutrabiotech GC376 CAS 1416992-39-6, high purity 3CLpro inhibitor broad-spectrum antiviral compound

GC376 CAS 1416992-39-6 Sodium Salt 98% Purity 3CLpro Inhibitor

High purity GC376 Sodium Salt powder, CAS 1416992-39-6, ≥98% HPLC purity. Potent 3CLpro protease inhibitor, antiviral research reagent, factory bulk supply with full certificates and fast global delivery.
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GC376 (CAS 1416992-39-6) Coronavirus 3CL Protease Inhibitor | FIP Antiviral (GC-373 Prodrug)

GC376 CAS 1416992-39-6
Coronavirus 3CL Protease Inhibitor (FIP Antiviral)

GC376 (CAS 1416992-39-6) is a broad-spectrum coronavirus 3C-like protease (3CLpro / Mpro) inhibitor. It covalently modifies the protease's catalytic cysteine, blocking polyprotein cleavage and viral maturation — notably effective against feline infectious peritonitis virus (FIPV). Often deployed as the prodrug GC373. Formula C21H30N3NaO8S, MW 507.5. Research-grade with COA.

AntiviralProtease Inhibitor3CLpro / MproCoronavirusFIP / FIPVGC376Veterinary ResearchGC-373
Request a Quote Technical Specs
507.5
MW (C21H30N/A)
≥98%
Purity (HPLC)
3CLpro
Viral protease block

Molecular Information

Name: GC376
CAS: 1416992-39-6
Formula: C21H30N3NaO8S
MW: 507.5 g/mol
Class: Coronavirus 3CL protease inhibitor
Core: Covalent aldehyde-sulfonate protease inhibitor (sodium salt)
Target: Viral 3CL protease (Mpro)
Activity: Polyprotein cleavage blockade
MP: Not firmly reported
Appearance: White to off-white powder
Synonyms: GC-376 / GC373 prodrug
Storage: -20°C, protect from light
1416992-39-6
🧪
CAS Number
507.5
⚖️
Molecular Weight
3CLpro / Mpro Inhibitor
🎯
Primary Activity
≥98%
✅
Purity

Product Technical Specifications

Complete physicochemical properties and QC parameters for GC376 (CAS 1416992-39-6)

📋 Physicochemical Properties

  • Product NameGC376
  • IUPAC Namesodium (2S)-1-hydroxy-2-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-3-(2-oxopyrrolidin-3-yl)propane-1-sulfonate
  • CAS Number1416992-39-6
  • SynonymsGC376; GC-376; GC373 (prodrug)
  • Molecular FormulaC21H30N3NaO8S
  • Molecular Weight507.5 g/mol
  • SourceSynthetic protease inhibitor (sodium salt)
  • AppearanceWhite to off-white powder
  • Water SolubilityModerate (sodium salt)
  • Organic SolubilityDMSO; some aqueous buffers
  • Compound ClassCoronavirus 3CL protease inhibitor
  • HS Code2934.99

🔬 Quality Control & Handling

  • Purity (HPLC)≥98%
  • FormCrystalline powder (sodium salt)
  • Primary TargetViral 3CL protease (Mpro / 3CLpro)
  • Assay ReadoutProtease activity; viral titers
  • SelectivityBroad-spectrum coronavirus protease
  • Storage Condition-20°C, sealed, protect from light
  • Solution StabilityPrepare fresh; DMSO stock at -20°C
  • ShippingCold chain recommended
  • QC DocumentationCOA / HPLC / NMR / MS / MSDS
  • Pack Sizes100mg / 500mg / 1g / 5g / 10g
  • Stock StatusIn Stock
  • Use StatementResearch / veterinary investigational; not for human use

Key Molecular Targets & Pathway Nodes

GC376 engages the molecular machinery and pathway nodes that define its research utility.

🧬 Viral 3CL Protease (Mpro) 🧬 Polyprotein processing 🟩 Coronavirus (FIPV) 🧬 Protease catalytic cysteine 🧬 Viral replication 🧪 Antiviral screening 💉 Host-pathogen factors 🦴 Viral maturation 🔬 Protease assays 💧 Covalent inhibition

How GC376 Works: Silencing the Viral Protease

GC376 covalently blocks the coronavirus main protease, stopping viral polyprotein maturation

1

Covalent Engagement of the Catalytic Cysteine

GC376 is a protease inhibitor that reacts with the catalytic cysteine in the viral 3C-like protease (Mpro / 3CLpro), forming a stable adduct that disables the active site.

2

Blockade of Polyprotein Cleavage

With Mpro inhibited, the virus can no longer autoprocess the translated polyprotein into the non-structural proteins required for replication and transcription.

3

Arrest of Viral Maturation & Spread

Failed polyprotein processing halts assembly of the replication complex, suppressing coronavirus production — the mechanism behind GC376/GC373 efficacy against FIPV and related CoVs.

⚖️ GC376 vs Comparators

  • GC376 (this product)Covalent 3CLpro inhibitor (sodium salt)
  • GC373Dimeric prodrug of GC376
  • NirmatrelvirSARS-CoV-2 3CLpro inhibitor (different scaffold)
  • Protease FocusCatalytic-cysteine covalent blockade
  • Research NicheFIP / coronavirus protease models

♻️ Downstream Biological Consequences

  • ProteaseCatalytic cysteine adduct
  • PolyproteinCleavage blocked
  • ReplicationNo functional nsps
  • CoronavirusFIPV & CoV suppression
  • AssaysFRET protease; plaque reduction
  • TherapyCombination antiviral strategies

Research Applications & Models

GC376 is the reference covalent protease inhibitor for coronavirus and FIP research.

💉

FIP (Feline Infectious Peritonitis)

Benchmark protease inhibitor studied for FIPV therapy, often as the GC373 prodrug.

FIP / FIPV
🟩

Coronavirus Protease Inhibition

Probes 3CLpro / Mpro blockade across coronaviruses.

Coronavirus
🔬

Protease Assay Development

FRET and activity-based protease profiling and SAR.

Protease
🧪

Broad-Spectrum Antiviral Screening

Evaluated against diverse CoV strains and enteric coronaviruses.

Screening
💉

Veterinary Models

Investigational antiviral work in feline and small-animal systems.

Veterinary
🦴

Combination Screening

Paired with nucleoside inhibitors (e.g., GS-441524) for synergy.

Combo

Key Literature & Landmark Publications

Landmark work on coronavirus protease inhibitors and FIP therapy.

Kim Y, et al. Broad-spectrum coronavirus 3C-like protease inhibitors (GC376). (protease pharmacology).
Landmark reference
Pedersen NC, et al. GC376 / GC373 in feline infectious peritonitis. (FIP therapy).
Landmark reference
Review. Viral protease inhibitors as coronavirus therapeutics.
Landmark reference
Investigator reports. GC376 PK and resistance profiling.
Landmark reference
Structure-activity literature. GC376 covalent warhead optimization.
Landmark reference

Available Sizes & Ordering

Research-grade GC376 (CAS 1416992-39-6) with full QC documentation; standard packs and bulk custom quantities supported.

TierPack SizeStock StatusSuitable ForLead Time
Standard100mgIn StockProtease / antiviral assaysSame/next-day ship
Medium500mgIn StockFIP / coronavirus modelsSame/next-day ship
Large1gIn StockIn vivo antiviral studiesSame/next-day ship
Bulk5gIn StockFormulation & screeningQuote to confirm
Industrial10g+Made to orderProcess developmentBatch delivery

💡 Reference sizes shown above; for exact pricing and availability please contact us for a quote. Bulk orders qualify for tiered discounts.

Frequently Asked Questions (FAQ)

What is GC376 and what does it inhibit?
GC376 (CAS 1416992-39-6) is a coronavirus 3C-like protease (3CLpro / Mpro) inhibitor that covalently blocks the protease's catalytic cysteine, preventing viral polyprotein maturation. Formula C21H30N3NaO8S, MW 507.5.
Why is GC376 used for FIP?
Feline infectious peritonitis virus (FIPV) is a coronavirus whose replication depends on 3CLpro; GC376 (often as the GC373 prodrug) stops viral maturation, making it a reference FIP antiviral.
How does GC376 differ from GS-441524?
GS-441524 blocks the viral RNA polymerase (RdRp), while GC376 blocks the viral main protease (Mpro). They target different steps and are often combined for synergy.
What readouts confirm activity?
FRET-based protease activity, polyprotein-processing western/immunoblot, and viral plaque / titer reduction.
How soluble is GC376 and how should it be prepared?
As a sodium salt it is more water-soluble than many antivirals; it is also soluble in DMSO. Prepare fresh, dilute into medium, and store DMSO stocks at -20°C protected from light.
Is QC documentation provided?
Every batch ships with a Certificate of Analysis (COA) including HPLC purity, NMR structural confirmation and MS data; MSDS/SDS and Certificates of Origin are available on request.

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Research-grade GC376 (CAS 1416992-39-6) — purity ≥98% HPLC, COA included
Viral Main Protease Inhibitor — request a quote today

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