GS-441524 ingredient by Nutrabiotech, professional FIPV inhibitor and coronavirus antiviral biochemical raw material for research and manufacturing
GS-441524 ingredient by Nutrabiotech, professional FIPV inhibitor and coronavirus antiviral biochemical raw material for research and manufacturing

GS‑441524 CAS 1191237‑69‑0 99.88% High‑Purity Powder RdRp Inhibitor Remdesivir Parent Nucleoside Analogue FIP‑V Antiviral Research Reagent

High‑purity 99.88% GS‑441524 crystalline powder CAS 1191237‑69‑0, potent RdRp inhibitor and Remdesivir nucleoside precursor for FIP‑V and coronavirus antiviral research.

Category: Tags: , , , , , , ,
GS-441524 (CAS 1191237-69-0) Antiviral Nucleoside Analog | Remdesivir Metabolite, FIP / Coronavirus RdRp Inhibitor

GS-441524 CAS 1191237-69-0
Antiviral Nucleoside Analog (Remdesivir Metabolite)

GS-441524 (CAS 1191237-69-0) is the active nucleoside metabolite of remdesivir. Intracellularly phosphorylated to its triphosphate, it terminates viral RNA chain elongation by the viral RNA-dependent RNA polymerase (RdRp), blocking replication of coronaviruses including feline infectious peritonitis virus (FIPV) and SARS-like CoVs. Formula C12H13N5O4, MW 291.26. Research-grade with COA.

AntiviralNucleoside AnalogCoronavirusFIP / FIPVRdRp InhibitorRemdesivir MetaboliteVeterinary ResearchGS-441524
Request a Quote Technical Specs
291.26
MW (C12H13N5O4)
≥98%
Purity (HPLC)
RdRp
Viral polymerase block

Molecular Information

Name: GS-441524
CAS: 1191237-69-0
Formula: C12H13N5O4
MW: 291.26 g/mol
Class: Adenosine nucleoside analog
Core: 1'-cyano pyrrolo[2,1-f][1,2,4]triazine ribonucleoside
Target: Viral RNA-dependent RNA polymerase (RdRp)
Activity: Chain-terminating antiviral
MP: Not firmly reported
Appearance: White to off-white powder
Synonyms: GS441524 / Remdesivir nucleoside
Storage: -20°C, protect from light
1191237-69-0
🧪
CAS Number
291.26
⚖️
Molecular Weight
Viral RdRp Inhibitor
🎯
Primary Activity
≥98%
✅
Purity

Product Technical Specifications

Complete physicochemical properties and QC parameters for GS-441524 (CAS 1191237-69-0)

📋 Physicochemical Properties

  • Product NameGS-441524
  • IUPAC Name(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile
  • CAS Number1191237-69-0
  • SynonymsGS-441524; GS441524; Remdesivir nucleoside
  • Molecular FormulaC12H13N5O4
  • Molecular Weight291.26 g/mol
  • SourceSynthetic nucleoside analog
  • AppearanceWhite to off-white powder
  • Water SolubilityLow to moderate
  • Organic SolubilityDMSO; aqueous buffer (pH-dependent)
  • Compound ClassAdenosine nucleoside analog / antiviral
  • HS Code2934.99

🔬 Quality Control & Handling

  • Purity (HPLC)≥98%
  • FormCrystalline powder
  • Primary TargetViral RNA-dependent RNA polymerase (RdRp)
  • Assay ReadoutViral replication / plaque reduction
  • SelectivityActive vs coronavirus polymerases
  • Storage Condition-20°C, sealed, protect from light
  • Solution StabilityDMSO stock stable weeks at -20°C
  • ShippingCold chain recommended
  • QC DocumentationCOA / HPLC / NMR / MS / MSDS
  • Pack Sizes100mg / 500mg / 1g / 5g / 10g
  • Stock StatusIn Stock
  • Use StatementResearch / veterinary investigational; not for human use

Key Molecular Targets & Pathway Nodes

GS-441524 engages the molecular machinery and pathway nodes that define its research utility.

🧬 Viral RdRp (RNA polymerase) 🧬 Viral RNA synthesis 🟩 Coronavirus (FIPV / SARS-CoV) 🧬 Nucleotide metabolism 🧬 Viral replication 💉 Host antiviral factors 🧪 Antiviral screening 💧 Phosphorylation to triphosphate 🦴 Chain termination 🔬 RNA synthesis assays

How GS-441524 Works: Terminating Viral RNA Synthesis

GS-441524 is phosphorylated intracellularly and caps viral RNA chains via the viral polymerase

1

Cellular Phosphorylation to the Active Triphosphate

After uptake, GS-441524 (the nucleoside core of remdesivir) is converted by host kinases to its 5'-triphosphate, the species that engages the viral replication machinery.

2

Incorporation by the Viral RdRp

The triphosphate is recognized and incorporated by the viral RNA-dependent RNA polymerase (RdRp) in place of the natural nucleotide during nascent viral RNA synthesis.

3

Chain Termination & Replication Arrest

Because the analog lacks the 3'-OH needed for further elongation, incorporation terminates the RNA chain, halting coronavirus genome replication and spread — the basis of its efficacy against FIPV and related CoVs.

⚖️ GS-441524 vs Comparators

  • GS-441524 (this product)Active nucleoside; RdRp chain terminator
  • Remdesivir (GS-5734)Phosphoramidate prodrug of GS-441524
  • MolnupiravirRdRp mutagen (different mechanism)
  • Nucleotide FocusIntracellular triphosphate is the effector
  • Research NicheFIP / coronavirus antiviral models

♻️ Downstream Biological Consequences

  • Viral RNAChain termination; no elongation
  • ReplicationPlaque / titer reduction
  • CellsHost kinase activation to triphosphate
  • CoronavirusFIPV & SARS-like CoV suppression
  • AssaysPlaque reduction; qRT-PCR
  • TherapyCombination antiviral strategies

Research Applications & Models

GS-441524 is the reference nucleoside for coronavirus and FIP antiviral research.

💉

FIP (Feline Infectious Peritonitis)

The benchmark nucleoside studied for FIPV antiviral therapy in veterinary research models.

FIP / FIPV
🟩

Coronavirus Antiviral Studies

Probes RdRp inhibition across SARS-like and endemic coronaviruses.

Coronavirus
🧪

Nucleoside Analog Profiling

Benchmark for chain-terminating antiviral nucleosides and SAR.

Nucleoside
🔬

RdRp & Replication Assays

Plaque reduction, qRT-PCR and polymerase incorporation studies.

RdRp
💉

Veterinary / Companion-Animal Models

Investigational antiviral work in feline and small-animal systems.

Veterinary
🦴

Combination Screening

Paired with protease inhibitors (e.g., GC376) for synergy.

Combo

Key Literature & Landmark Publications

Landmark work on remdesivir-class nucleosides and FIP antiviral therapy.

Warren TK, et al. Therapeutic efficacy of remdesivir (GS-5734) in a model of SARS-CoV. (nucleoside antiviral).
Landmark reference
Pedersen NC, et al. GS-441524 in the treatment of feline infectious peritonitis. (FIP antiviral).
Landmark reference
Gordon CJ, et al. Remdesivir is a direct-acting antiviral: characterization of its nucleoside metabolite.
Landmark reference
Investigator reports. GS-441524 pharmacokinetics and FIPV models.
Landmark reference
Review. Nucleoside analogs as coronavirus RdRp inhibitors.
Landmark reference

Available Sizes & Ordering

Research-grade GS-441524 (CAS 1191237-69-0) with full QC documentation; standard packs and bulk custom quantities supported.

TierPack SizeStock StatusSuitable ForLead Time
Standard100mgIn StockAntiviral / cell assaysSame/next-day ship
Medium500mgIn StockFIP / coronavirus modelsSame/next-day ship
Large1gIn StockIn vivo antiviral studiesSame/next-day ship
Bulk5gIn StockFormulation & screeningQuote to confirm
Industrial10g+Made to orderProcess developmentBatch delivery

💡 Reference sizes shown above; for exact pricing and availability please contact us for a quote. Bulk orders qualify for tiered discounts.

Frequently Asked Questions (FAQ)

What is GS-441524 and how is it related to remdesivir?
GS-441524 (CAS 1191237-69-0) is the active nucleoside metabolite of remdesivir. Inside cells it is phosphorylated to a triphosphate that inhibits the viral RNA-dependent RNA polymerase. Formula C12H13N5O4, MW 291.26.
Why is GS-441524 studied for FIP?
Feline infectious peritonitis virus (FIPV) is a coronavirus; GS-441524 terminates viral RNA synthesis, making it the reference nucleoside in FIP antiviral research.
Is GS-441524 the same as remdesivir?
No. Remdesivir is a phosphoramidate prodrug; GS-441524 is the nucleoside core that becomes active after cellular phosphorylation. GS-441524 is the directly antiviral species.
What readouts confirm antiviral activity?
Plaque-reduction and viral-titer assays, qRT-PCR of viral RNA, and biochemical RdRp incorporation / chain-termination studies.
How soluble is GS-441524 and how should it be prepared?
It is soluble in DMSO and, depending on pH, in aqueous buffer; poorly in plain water. Prepare a DMSO stock, dilute into medium (final DMSO ≤0.1% v/v), and store at -20°C protected from light.
Is QC documentation provided?
Every batch ships with a Certificate of Analysis (COA) including HPLC purity, NMR structural confirmation and MS data; MSDS/SDS and Certificates of Origin are available on request.

Need GS-441524 for Your Research?

Research-grade GS-441524 (CAS 1191237-69-0) — purity ≥98% HPLC, COA included
Viral RdRp Inhibitor — request a quote today

Request a Quote →

Related products