Ibutamoren Mesylate MK-677 (CAS 159752-10-0) Ghrelin Receptor Agonist | Oral GH Secretagogue

Ibutamoren Mesylate CAS 159752-10-0
MK-677 — Oral Ghrelin / Growth Hormone Secretagogue

Name: Ibutamoren Mesylate (MK-677)
Brand: Nutrabiotech Chem
SKU: IBUTAMOREN-MESYLATE-159752-10-0
Price: Inquiry USD
Availability: InStock

Ibutamoren mesylate (CAS 159752-10-0), also MK-677 or Nutrobal, is a non-peptide, orally active agonist of the ghrelin / GHS-R1a receptor. It stimulates endogenous growth hormone (GH) and IGF-1 release without suppressing gonadal or thyroid axes — a foundational tool for GH/IGF-1, sarcopenia, metabolic and body-composition research. Formula C28H40N4O8S2, MW 624.8. Research-grade with COA.

Ghrelin AgonistGHS-R1aMK-677Growth HormoneIGF-1SarcopeniaMetabolicIbutamoren

Request a Quote Technical Specs

624.8

MW (C28H40N4O8S2)

≥98%

Purity (HPLC)

GHS-R1a

Ghrelin receptor

Molecular Information

Name: Ibutamoren Mesylate (MK-677)
CAS: 159752-10-0
Formula: C28H40N4O8S2
MW: 624.8 g/mol
Class: Ghrelin receptor agonist
Core: Spiroindoline GHS agonist (mesylate salt)
Target: GHS-R1a (ghrelin receptor)
Activity: GH / IGF-1 secretagogue
MP: Not firmly reported
Appearance: White to off-white powder
Synonyms: MK-677 / Nutrobal
Storage: -20°C, protect from light

159752-10-0

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CAS Number

624.8

⚖️

Molecular Weight

GHS-R1a Agonist

🎯

Primary Activity

≥98%

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Purity

Product Technical Specifications

Complete physicochemical properties and QC parameters for Ibutamoren Mesylate (MK-677) (CAS 159752-10-0)

📋 Physicochemical Properties

Product NameIbutamoren Mesylate (MK-677)
IUPAC Name2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4'-piperidine]-1'-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide methanesulfonate
CAS Number159752-10-0
SynonymsIbutamoren; MK-677; MK677; Nutrobal
Molecular FormulaC28H40N4O8S2
Molecular Weight624.8 g/mol
SourceSynthetic GHS agonist (mesylate salt)
AppearanceWhite to off-white powder
Water SolubilityLow
Organic SolubilityDMSO; ethanol
Compound ClassGhrelin receptor agonist / GH secretagogue
HS Code2934.99

🔬 Quality Control & Handling

Purity (HPLC)≥98%
FormCrystalline powder (mesylate salt)
Primary TargetGHS-R1a (ghrelin receptor)
Assay ReadoutGH / IGF-1 elevation
SelectivityOral, long-acting GHS agonist
Storage Condition-20°C, sealed, protect from light
Solution StabilityDMSO stock stable weeks at -20°C
ShippingRoom temp / cold chain
QC DocumentationCOA / HPLC / NMR / MS / MSDS
Pack Sizes100mg / 500mg / 1g / 5g / 10g
Stock StatusIn Stock
Use StatementResearch use only; not for human/clinical use

Key Molecular Targets & Pathway Nodes

Ibutamoren Mesylate (MK-677) engages the molecular machinery and pathway nodes that define its research utility.

🧬 GHS-R1a (ghrelin receptor) 🧬 Growth Hormone (GH) 🧬 IGF-1 axis 🧬 Hypothalamus-Pituitary 🍲 Appetite / energy balance 💧 Lean mass / body composition 🦴 Muscle & bone 🧪 Metabolic regulation 🔬 Endocrine assays 🧭 Sleep architecture

How Ibutamoren Works: Mimicking Ghrelin's GH Pulse

Ibutamoren binds GHS-R1a and drives endogenous growth hormone and IGF-1 without axis suppression

Agonism of the Ghrelin / GHS-R1a Receptor

Ibutamoren is a small-molecule agonist of the growth-hormone-secretagogue receptor (GHS-R1a), the target of the endogenous ligand ghrelin, activating it in the hypothalamus and pituitary.

Endogenous GH & IGF-1 Release

Receptor activation stimulates pulsatile growth hormone secretion from the pituitary, which in turn raises hepatic and local IGF-1 production — without the negative feedback that suppresses gonadal or thyroid axes.

Anabolic, Metabolic & Body-Composition Effects

Sustained GH/IGF-1 elevation supports lean-mass accrual, bone turnover, appetite and metabolic regulation, the phenotypes studied in sarcopenia, aging and body-composition research.

⚖️ Ibutamoren Mesylate (MK-677) vs Comparators

Ibutamoren (this product)Oral GHS-R1a agonist; GH/IGF-1 secretagogue
Ghrelin (endogenous)Endogenous ligand of GHS-R1a
GHRH analogsHypothalamic GH-releasing hormone axis
Selective EdgeOral, long-acting; spares gonadal/thyroid axes
Research NicheSarcopenia, aging, body composition

♻️ Downstream Biological Consequences

EndocrineGH pulse & IGF-1 rise
MuscleLean-mass & anabolic signaling
BoneTurnover / density support
MetabolismAppetite & energy balance
BodyComposition readouts
SleepArchitecture modulation

Research Applications & Models

Ibutamoren (MK-677) is a standard tool for GH/IGF-1 and body-composition research.

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GH / IGF-1 Research

The reference oral secretagogue for growth-hormone and IGF-1 elevation studies.

GH / IGF-1

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Sarcopenia & Muscle Models

Studied for lean-mass preservation and anabolic signaling in aging.

Sarcopenia

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Metabolic & Obesity Studies

Probes appetite, energy expenditure and metabolic regulation.

Metabolic

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Sleep & Recovery Research

Investigated for slow-wave sleep and recovery phenotypes.

Sleep

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Aging Models

Used in frailty, bone and healthy-aging paradigms.

Aging

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Endocrine Assay Development

Benchmark for GHS-R1a pathway and secretagogue screening.

Endocrine

Key Literature & Landmark Publications

Landmark work on ghrelin mimetics and GH/IGF-1 secretagogues.

Smith RG, et al. Ghrelin receptor agonists as growth hormone secretagogues. (GHS pharmacology).

Landmark reference

Murphy MG, et al. MK-677 (ibutamoren) increases GH and IGF-1 in humans. (clinical pharmacology).

Landmark reference

Investigator reports. Ibutamoren in sarcopenia and body-composition models.

Landmark reference

Review. Oral ghrelin mimetics in metabolic and aging research.

Landmark reference

Patent / development literature. MK-677 structure-activity and PK.

Landmark reference

Available Sizes & Ordering

Research-grade Ibutamoren Mesylate / MK-677 (CAS 159752-10-0) with full QC documentation; standard packs and bulk custom quantities supported.

Tier	Pack Size	Stock Status	Suitable For	Lead Time
Standard	100mg	In Stock	GH / endocrine assays	Same/next-day ship
Medium	500mg	In Stock	Cell & receptor studies	Same/next-day ship
Large	1g	In Stock	In vivo models	Same/next-day ship
Bulk	5g	In Stock	Screening & formulation	Quote to confirm
Industrial	10g+	Made to order	Process development	Batch delivery

💡 Reference sizes shown above; for exact pricing and availability please contact us for a quote. Bulk orders qualify for tiered discounts.

Frequently Asked Questions (FAQ)

What is ibutamoren mesylate (MK-677)?

Ibutamoren mesylate (CAS 159752-10-0), also MK-677 or Nutrobal, is an oral, non-peptide agonist of the ghrelin / GHS-R1a receptor that stimulates endogenous growth hormone and IGF-1. Formula C28H40N4O8S2, MW 624.8.

Does MK-677 suppress other hormones?

Unlike exogenous GH, ibutamoren raises GH/IGF-1 while largely sparing the gonadal and thyroid axes, which is why it is studied for safer, physiologic GH elevation.

What models use ibutamoren?

Sarcopenia and muscle-preserving studies, metabolic / obesity and appetite research, aging and body-composition paradigms, and sleep / recovery models.

What readouts confirm activity?

Serum/plasma GH and IGF-1 elevation, GHS-R1a activation assays, and downstream lean-mass / metabolic readouts.

How soluble is ibutamoren and how should it be prepared?

It is soluble in DMSO and ethanol; poorly in water. Prepare a DMSO stock, dilute into medium (final DMSO ≤0.1% v/v), and store at -20°C protected from light.

Is QC documentation provided?

Every batch ships with a Certificate of Analysis (COA) including HPLC purity, NMR structural confirmation and MS data; MSDS/SDS and Certificates of Origin are available on request.

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Research-grade Ibutamoren Mesylate (MK-677) (CAS 159752-10-0) — purity ≥98% HPLC, COA included
GHS-R1a Agonist — request a quote today

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Ibutamoren Mesylate CAS 159752-10-0 MK-677 Powder 98% Purity Research Chemical