Nutrabiotech Selinexor 98% 1G Powder, high purity Selinexor KPT-330 powder, selective XPO1 inhibitor, SINE nuclear export blocker, tumor suppressor activator, oncology research raw material

High Purity Selinexor Powder CAS 1393477-72-9 Selective Nuclear Export Inhibitor

High purity Selinexor powder CAS 1393477-72-9 with 98% HPLC purity. Novel selective XPO1 nuclear export inhibitor for anticancer research, factory bulk supply, complete COA/MSDS, fast global delivery for pharmaceutical lab research.
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Selinexor KPT-330 (CAS 1393477-72-9) XPO1 / CRM1 Nuclear Export Inhibitor | SINE Oncology

Selinexor CAS 1393477-72-9
First-in-Class XPO1 (CRM1) Nuclear Export Inhibitor

Selinexor (CAS 1393477-72-9), also KPT-330, is a first-in-class Selective Inhibitor of Nuclear Export (SINE). It covalently binds Cys528 in the nuclear export protein XPO1 (CRM1), blocking nuclear export of tumor-suppressor and growth-regulatory proteins — forcing apoptosis and immune modulation. Studied/approved in multiple myeloma and DLBCL. Formula C17H11F6N7O, MW 443.3. Research-grade with COA.

XPO1 InhibitorCRM1SINESelinexorKPT-330OncologyNuclear ExportApoptosis
Request a Quote Technical Specs
443.3
MW (C17H11F6N7O)
≥98%
Purity (HPLC)
XPO1
CRM1 blockade

Molecular Information

Name: Selinexor (KPT-330)
CAS: 1393477-72-9
Formula: C17H11F6N7O
MW: 443.3 g/mol
Class: Selective Inhibitor of Nuclear Export (SINE)
Core: Trifluoromethylphenyl triazolyl hydrazide
Target: XPO1 / CRM1 nuclear export protein
Activity: Covalent Cys528 blockade
MP: Not firmly reported
Appearance: White to off-white powder
Synonyms: KPT-330
Storage: -20°C, protect from light
1393477-72-9
🧪
CAS Number
443.3
⚖️
Molecular Weight
XPO1 / CRM1 Inhibitor
🎯
Primary Activity
≥98%
✅
Purity

Product Technical Specifications

Complete physicochemical properties and QC parameters for Selinexor (CAS 1393477-72-9)

📋 Physicochemical Properties

  • Product NameSelinexor (KPT-330)
  • IUPAC Name(Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-N'-pyrazin-2-ylprop-2-enehydrazide
  • CAS Number1393477-72-9
  • SynonymsSelinexor; KPT-330
  • Molecular FormulaC17H11F6N7O
  • Molecular Weight443.3 g/mol
  • SourceSynthetic SINE inhibitor
  • AppearanceWhite to off-white powder
  • Water SolubilityLow
  • Organic SolubilityDMSO; some aqueous buffers
  • Compound ClassXPO1 / CRM1 nuclear export inhibitor
  • HS Code2934.99

🔬 Quality Control & Handling

  • Purity (HPLC)≥98%
  • FormCrystalline powder
  • Primary TargetXPO1 (CRM1) nuclear export protein
  • Assay ReadoutNuclear retention; apoptosis
  • SelectivityCovalent Cys528 of XPO1
  • Storage Condition-20°C, sealed, protect from light
  • Solution StabilityDMSO stock stable weeks at -20°C
  • ShippingCold chain recommended
  • QC DocumentationCOA / HPLC / NMR / MS / MSDS
  • Pack Sizes100mg / 500mg / 1g / 5g / 10g
  • Stock StatusIn Stock
  • Use StatementResearch / investigational; not for human use

Key Molecular Targets & Pathway Nodes

Selinexor engages the molecular machinery and pathway nodes that define its research utility.

🧬 XPO1 (CRM1) 🧬 Nuclear export 🧬 Tumor suppressors (p53, p21) 🧬 NF-κB 🦴 Apoptosis 🧪 Immune cells 🔬 Nuclear-cytoplasmic transport 🧭 Oncology signaling 💧 Proteostasis 🧬 Anti-viral export

How Selinexor Works: Locking Tumor Suppressors in the Nucleus

Selinexor blocks XPO1, so tumor-suppressor and regulatory proteins can no longer leave the nucleus

1

Covalent Blockade of XPO1 (CRM1)

Selinexor is a SINE compound that binds covalently to Cys528 in the nuclear export receptor XPO1 (CRM1), the major exporter of proteins from nucleus to cytoplasm.

2

Nuclear Retention of Regulatory Proteins

With XPO1 disabled, tumor-suppressor and growth-regulatory proteins (p53, p21, FOXO, IκBα, STATs) accumulate in the nucleus where they can act.

3

Apoptosis, Cell-Cycle Arrest & Immune Modulation

Nuclear retention triggers cell-cycle arrest, apoptosis and altered immune function — the basis of selinexor's activity in myeloma, lymphoma and other malignancies, and its investigational antiviral use.

⚖️ Selinexor vs Comparators

  • Selinexor (this product)SINE; covalent XPO1 (Cys528) inhibitor
  • Leptomycin BNatural CRM1 inhibitor (toxic)
  • Other SINEs (eltanexor)Next-gen XPO1 inhibitors
  • Selective EdgeOral; reversible-binding SINE class
  • Research NicheOncology & nuclear-export studies

♻️ Downstream Biological Consequences

  • TransportNuclear export halted
  • Tumor suppressorsp53/p21 nuclear retention
  • Cell cycleG1/G2 arrest
  • SurvivalApoptosis induction
  • ImmuneModulated anti-tumor response
  • VirusImpaired viral exploitation

Research Applications & Models

Selinexor is the reference XPO1 inhibitor for oncology and nuclear-export research.

🧭

Oncology (Myeloma, Lymphoma)

Studied in multiple myeloma, DLBCL and solid tumors as the founding SINE agent.

Oncology
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XPO1 / CRM1 Inhibition

Benchmark for nuclear-export blockade and CRM1 covalent inhibition.

XPO1
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p53 / Tumor-Suppressor Studies

Probes nuclear retention of p53 and growth regulators.

p53
🦴

Apoptosis & Cell-Cycle Assays

Measures arrest and programmed cell death.

Apoptosis
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Anti-Viral (Nuclear Export)

Investigated for viruses that hijack nuclear export.

Anti-viral
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Combination Screening

Paired with proteasome inhibitors and IMiDs for synergy.

Combo

Key Literature & Landmark Publications

Landmark work on selective inhibitors of nuclear export (SINE) and XPO1.

Kau TR, et al. Relocalization of CRM1 and SINE inhibitors. (nuclear export biology).
Landmark reference
Attal M, et al. Selinexor in multiple myeloma (clinical). (SINE therapy).
Landmark reference
Investigator reports. KPT-330 XPO1 covalent inhibition.
Landmark reference
Review. XPO1 as a cancer therapeutic target.
Landmark reference
Structure-activity literature. SINE optimization and selectivity.
Landmark reference

Available Sizes & Ordering

Research-grade Selinexor / KPT-330 (CAS 1393477-72-9) with full QC documentation; standard packs and bulk custom quantities supported.

TierPack SizeStock StatusSuitable ForLead Time
Standard100mgIn StockXPO1 / oncology assaysSame/next-day ship
Medium500mgIn StockCell & nuclear-export studiesSame/next-day ship
Large1gIn StockIn vivo tumor modelsSame/next-day ship
Bulk5gIn StockScreening & formulationQuote to confirm
Industrial10g+Made to orderProcess developmentBatch delivery

💡 Reference sizes shown above; for exact pricing and availability please contact us for a quote. Bulk orders qualify for tiered discounts.

Frequently Asked Questions (FAQ)

What is selinexor and what does it inhibit?
Selinexor (CAS 1393477-72-9), also KPT-330, is a first-in-class Selective Inhibitor of Nuclear Export (SINE) that binds Cys528 in XPO1 (CRM1), blocking nuclear export. Formula C17H11F6N7O, MW 443.3.
Why does blocking nuclear export kill cancer cells?
Tumor cells rely on exporting tumor-suppressor and regulatory proteins. Selinexor traps p53, p21 and others in the nucleus, driving cell-cycle arrest and apoptosis.
In which cancers is selinexor studied?
Multiple myeloma, diffuse large B-cell lymphoma and several solid tumors, often combined with proteasome inhibitors or immunomodulatory drugs.
What readouts confirm XPO1 inhibition?
Nuclear accumulation of cargo proteins (p53, IκBα), reduced cytoplasmic export, and downstream apoptosis / cell-cycle arrest.
How soluble is selinexor and how should it be prepared?
It is soluble in DMSO and some aqueous buffers; poorly in water. Prepare a DMSO stock, dilute into medium (final DMSO ≤0.1% v/v), and store at -20°C protected from light.
Is QC documentation provided?
Every batch ships with a Certificate of Analysis (COA) including HPLC purity, NMR structural confirmation and MS data; MSDS/SDS and Certificates of Origin are available on request.

Need Selinexor for Your Research?

Research-grade Selinexor (CAS 1393477-72-9) — purity ≥98% HPLC, COA included
XPO1 (CRM1) Inhibitor — request a quote today

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Weight 1 g

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