CAS 924012-43-1 Centanafadine Hydrochloride high purity powder triple reuptake inhibitor for ADHD drug research

Centanafadine Hydrochloride CAS 924012-43-1 98% Purity Triple Reuptake Inhibitor Powder

High purity Centanafadine Hydrochloride powder CAS 924012-43-1 with 98% HPLC purity. Novel triple reuptake inhibitor for ADHD and neurological research, factory bulk supply, full certificates and fast global delivery.
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Centanafadine Hydrochloride SNDX-561 (CAS 924012-43-1) Triple Reuptake Inhibitor (NDRI)

Centanafadine Hydrochloride CAS 924012-43-1
Triple Reuptake Inhibitor (NDRI, SNDX-561)

Centanafadine hydrochloride (CAS 924012-43-1), also SNDX-561, is a triple reuptake inhibitor that blocks the transporters for norepinephrine, dopamine and serotonin (NET/DAT/SERT), enhancing monoaminergic tone. Studied as a next-generation antidepressant / ADHD agent with a potentially improved tolerability profile. Supplied as the hydrochloride salt. Formula C15H15N (free base), MW 209.29. Research-grade with COA.

Triple ReuptakeNDRICentanafadineSNDX-561AntidepressantADHDMonoamineNET/DAT/SERT
Request a Quote Technical Specs
209.29
MW (free base)
≥98%
Purity (HPLC)
NET/DAT/SERT
Triple block

Molecular Information

Name: Centanafadine Hydrochloride (SNDX-561)
CAS: 924012-43-1
Formula: C15H15N (free base)
MW: 209.29 g/mol (free base)
Class: Triple reuptake inhibitor (NDRI)
Core: Naphthyl azabicyclo[3.1.0]hexane
Target: NET / DAT / SERT transporters
Activity: Monoamine reuptake inhibition
MP: Not firmly reported
Appearance: White to off-white powder
Synonyms: SNDX-561
Storage: -20°C, protect from light
924012-43-1
🧪
CAS Number
209.29
⚖️
Molecular Weight
Triple Reuptake Inhibitor
🎯
Primary Activity
≥98%
✅
Purity

Product Technical Specifications

Complete physicochemical properties and QC parameters for Centanafadine Hydrochloride (CAS 924012-43-1)

📋 Physicochemical Properties

  • Product NameCentanafadine Hydrochloride (SNDX-561)
  • IUPAC Name(1R,5S)-1-naphthalen-2-yl-3-azabicyclo[3.1.0]hexane hydrochloride
  • CAS Number924012-43-1
  • SynonymsCentanafadine; SNDX-561
  • Molecular FormulaC15H15N (free base)
  • Molecular Weight209.29 g/mol (free base)
  • SourceSynthetic NDRI (hydrochloride salt)
  • AppearanceWhite to off-white powder
  • Water SolubilityModerate (salt)
  • Organic SolubilityDMSO; ethanol
  • Compound ClassTriple reuptake inhibitor / antidepressant
  • HS Code2934.99

🔬 Quality Control & Handling

  • Purity (HPLC)≥98%
  • FormCrystalline powder (hydrochloride salt)
  • Primary TargetNET / DAT / SERT transporters
  • Assay ReadoutMonoamine uptake; behavior
  • SelectivityBalanced triple reuptake
  • Storage Condition-20°C, sealed, protect from light
  • Solution StabilityDMSO stock stable weeks at -20°C
  • ShippingRoom temp / cold chain
  • QC DocumentationCOA / HPLC / NMR / MS / MSDS
  • Pack Sizes100mg / 500mg / 1g / 5g / 10g
  • Stock StatusIn Stock
  • Use StatementResearch use only; not for human/clinical use

Key Molecular Targets & Pathway Nodes

Centanafadine Hydrochloride engages the molecular machinery and pathway nodes that define its research utility.

🧬 NET (norepinephrine) 🧬 DAT (dopamine) 🧬 SERT (serotonin) 🧪 Monoamine transporters 🧭 Depression circuits 🧭 ADHD / cognition 🔬 Transporter assays 🦴 Monoaminergic tone 💧 Neurotransmitter reuptake 🧬 Synaptic signaling

How Centanafadine Works: Boosting All Three Monoamines

Centanafadine blocks norepinephrine, dopamine and serotonin reuptake together

1

Inhibition of NET, DAT & SERT Transporters

Centanafadine is a triple reuptake inhibitor (NDRI) that blocks the norepinephrine (NET), dopamine (DAT) and serotonin (SERT) transporters simultaneously.

2

Elevated Synaptic Monoamines

Blocking reuptake leaves more norepinephrine, dopamine and serotonin in the synaptic cleft, enhancing monoaminergic neurotransmission across circuits.

3

Antidepressant / Pro-Cognitive Effects

The combined monoamine elevation underlies its studied antidepressant and ADHD / pro-cognitive phenotypes, with a profile distinct from SSRIs/SNRIs.

⚖️ Centanafadine Hydrochloride vs Comparators

  • Centanafadine (this product)Triple (NET/DAT/SERT) reuptake inhibitor
  • SSRIs (fluoxetine)SERT-selective only
  • SNRIs (venlafaxine)NET + SERT
  • Selective EdgeAdds DAT (dopamine) to the mix
  • Research NicheDepression / ADHD & monoamines

♻️ Downstream Biological Consequences

  • TransportersNET/DAT/SERT blocked
  • SynapseAll three amines elevated
  • MoodAntidepressant readouts
  • CognitionADHD / pro-cognitive models
  • CircuitMonoaminergic tone up
  • Comparevs SSRI / SNRI profiles

Research Applications & Models

Centanafadine is the reference triple reuptake inhibitor for mood and cognition research.

🧭

Depression Research

Next-generation NDRI studied for major depressive disorder.

Depression
🧭

ADHD / Cognition Models

Probed for attention and pro-cognitive phenotypes.

ADHD
🧪

Monoamine Reuptake Profiling

Benchmark for balanced NET/DAT/SERT inhibition.

Reuptake
🔬

Transporter Assays

Radioligand and uptake assays for SERT/NET/DAT.

Assays
🦴

Neuropharmacology

Monoaminergic circuit and behavior studies.

Neuro
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Drug-Discovery Screening

Differentiation from SSRI/SNRI leads.

Screening

Key Literature & Landmark Publications

Landmark work on triple reuptake inhibitors and SNDX-561.

Investigator reports. Centanafadine (SNDX-561) triple reuptake inhibition.
Landmark reference
Review. Triple reuptake inhibitors in depression.
Landmark reference
Preclinical reports. Centanafadine antidepressant / ADHD phenotypes.
Landmark reference
Clinical literature. NDRI tolerability vs SSRIs/SNRIs.
Landmark reference
Structure-activity literature. SNDX-561 optimization.
Landmark reference

Available Sizes & Ordering

Research-grade Centanafadine Hydrochloride / SNDX-561 (CAS 924012-43-1) with full QC documentation; standard packs and bulk custom quantities supported.

TierPack SizeStock StatusSuitable ForLead Time
Standard100mgIn StockTransporter / neuro assaysSame/next-day ship
Medium500mgIn StockCell & uptake studiesSame/next-day ship
Large1gIn StockIn vivo behavior modelsSame/next-day ship
Bulk5gIn StockScreening & formulationQuote to confirm
Industrial10g+Made to orderProcess developmentBatch delivery

💡 Reference sizes shown above; for exact pricing and availability please contact us for a quote. Bulk orders qualify for tiered discounts.

Frequently Asked Questions (FAQ)

What is centanafadine and what does it inhibit?
Centanafadine hydrochloride (CAS 924012-43-1), also SNDX-561, is a triple reuptake inhibitor (NDRI) that blocks the norepinephrine (NET), dopamine (DAT) and serotonin (SERT) transporters. Formula C15H15N (free base), MW 209.29.
How is it different from SSRIs or SNRIs?
SSRIs hit only SERT and SNRIs hit NET+SERT; centanafadine additionally blocks DAT (dopamine), engaging all three monoamines for a broader profile.
What conditions is it studied for?
Major depressive disorder and ADHD / pro-cognitive and attention paradigms, with interest in tolerability versus older agents.
What readouts confirm activity?
Radioligand binding and uptake assays for SERT/NET/DAT, synaptic monoamine measurements, and behavioral tests.
How soluble is centanafadine and how should it be prepared?
As a hydrochloride it is water-soluble and also dissolves in DMSO/ethanol. Prepare aqueous or DMSO stocks and store at -20°C protected from light.
Is QC documentation provided?
Every batch ships with a Certificate of Analysis (COA) including HPLC purity, NMR structural confirmation and MS data; MSDS/SDS and Certificates of Origin are available on request.

Need Centanafadine Hydrochloride for Your Research?

Research-grade Centanafadine Hydrochloride (CAS 924012-43-1) — purity ≥98% HPLC, COA included
NET / DAT / SERT Inhibitor — request a quote today

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Weight 1 g

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